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Dennis K Watson, PhD
Professor of Pathology & Laboratory Medicine
College of Medicine
MUSC

Email: watsondk@musc.edu
 
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Dennis K Watson, PhD

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Research Interest:

I have long standing interest and expertise in the areas of cellular and molecular biology, gene discovery, cellular differentiation and molecular oncology. During the initial stages of oncogene discovery, I was among the first to molecularly characterize the viral and cellular myc genes. I was also among the discoverers of the Ets gene family and have been directly responsible for the isolation and characterization of Ets gene products and their role in cellular proliferation, differentiation and etiology of cancer. In addition to continuing to evaluate the role of specific Ets genes in cellular transformation, my laboratory has identified and functionally characterized genes with altered expression during cancer progression. My research program has expertise in using in vitro and in vivo loss of function and gain of function approaches and molecular analyses to examine the functional significance of altered expression and the regulatory networks that such changes control. Recent studies in the laboratory have explored the role of regulatory circuitry in tumor cell interaction with the microenvironment.

Positions:
Associate Director of Education & Training, Hollings Cancer Center, Medical University of South Carolina

Selected Publications:

1.McDonald LT, Russell DL, Kelly RR, Xiong Y, Motamarry A, Patel RK, Jones JA, Watson PM, Turner DP, Watson DK, Soloff AC, Findlay VJ, LaRue AC. Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment. Neoplasia. .17(5):434-48, 2015. PMID: 26025666 PMCID: PMC4468366
View in: PubMed

2.Liu F, Li D, Yu YY, Kang I, Cha MJ, Kim JY, Park C, Watson DK, Wang T, Choi K. Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2. EMBO Rep. .16(5):654-69, 2015. PMID: 25802403 PMCID: PMC4428045
View in: PubMed

3.Scheiber MN, Watson PM, Rumboldt T, Stanley C, Wilson RC, Findlay VJ, Anderson PE, Watson DK. FLI1 expression is correlated with breast cancer cellular growth, migration, and invasion and altered gene expression. Neoplasia. .16(10):801-13, 2014. PMID: 25379017 PMCID: PMC4212256
View in: PubMed

4.Findlay VJ, Wang C, Nogueira LM, Hurst K, Quirk D, Ethier SP, Staveley O'Carroll KF, Watson DK, Camp ER. SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression. Mol Cancer Ther. .13(11):2713-26, 2014. PMID: 25249558 PMCID: PMC4221636
View in: PubMed

5.Lennard Richard ML, Nowling TK, Brandon D, Watson DK, Zhang XK. Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation. Mol Immunol. .63(2):566-73, 2014. PMID: 25108845 PMCID: PMC4254164
View in: PubMed

6.Findlay VJ, Wang C, Watson DK, Camp ER. Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer. Cancer Gene Ther. .21(5):181-7, 2014. PMID: 24787239 PMCID: PMC4041800
View in: PubMed

7.Abedin MJ, Nguyen A, Jiang N, Perry CE, Shelton JM, Watson DK, Ferdous A. Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation. Circ Res. .114(11):1690-9, 2014. PMID: 24727028 PMCID: PMC4080722
View in: PubMed

8.Findlay VJ, Moretz RE, Wang C, Vaena SG, Bandurraga SG, Ashenafi M, Marshall DT, Watson DK, Camp ER. Slug expression inhibits calcitriol-mediated sensitivity to radiation in colorectal cancer. Mol Carcinog. .53 Suppl 1:E130-9, 2013. PMID: 23996472 PMCID: PMC3858479
View in: PubMed

9.Suzuki E, Williams S, Sato S, Gilkeson G, Watson DK, Zhang XK. The transcription factor Fli-1 regulates monocyte, macrophage and dendritic cell development in mice. Immunology. .139(3):318-27, 2013. PMID: 23320737 PMCID: PMC3701178
View in: PubMed

10.Camp ER, Wang C, Little EC, Watson PM, Pirollo KF, Rait A, Cole DJ, Chang EH, Watson DK. Transferrin receptor targeting nanomedicine delivering wild-type p53 gene sensitizes pancreatic cancer to gemcitabine therapy. Cancer Gene Ther. .20(4):222-8, 2013. PMID: 23470564 PMCID: PMC3746039
View in: PubMed

11.Findlay VJ, LaRue AC, Turner DP, Watson PM, Watson DK. Understanding the role of ETS-mediated gene regulation in complex biological processes. Adv Cancer Res. .119:1-61, 2013. PMID: 23870508
View in: PubMed

12.Qin Z, Dai L, Defee M, Findlay VJ, Watson DK, Toole BP, Cameron J, Peruzzi F, Kirkwood K, Parsons C. Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection. J Virol. .87(1):621-35, 2012. PMID: 23097457 PMCID: PMC3536420
View in: PubMed

13.Suzuki E, Karam E, Williams S, Watson DK, Gilkeson G, Zhang XK. Fli-1 transcription factor affects glomerulonephritis development by regulating expression of monocyte chemoattractant protein-1 in endothelial cells in the kidney. Clin Immunol. .145(3):201-8, 2012. PMID: 23108091 PMCID: PMC3501541
View in: PubMed

14.Rossa C, Sommer G, Spolidorio LC, Rosenzweig SA, Watson DK, Kirkwood KL. Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion. PLoS One. .7(9):e45197, 2012. PMID: 23028842 PMCID: PMC3445460
View in: PubMed

15.Little EC, Wang C, Watson PM, Watson DK, Cole DJ, Camp ER. Novel immunocompetent murine models representing advanced local and metastatic pancreatic cancer. J Surg Res. .176(2):359-66, 2011. PMID: 22221605 PMCID: PMC3406409
View in: PubMed

16.Moussa O, Ciupek A, Watson DK, Halushka PV. Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring. Prostaglandins Other Lipid Mediat. .96(1-4):41-4, 2011. PMID: 21983220 PMCID: PMC3215826
View in: PubMed

17.Kornblau SM, Qiu YH, Zhang N, Singh N, Faderl S, Ferrajoli A, York H, Qutub AA, Coombes KR, Watson DK. Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia. Blood. .118(20):5604-12, 2011. PMID: 21917756 PMCID: PMC3217360
View in: PubMed

18.Turner DP, Findlay VJ, Moussa O, Semenchenko VI, Watson PM, LaRue AC, Desouki MM, Fraig M, Watson DK. Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression. Prostate. .71(16):1723-35, 2011. PMID: 21446014 PMCID: PMC3128180
View in: PubMed

19.Camp ER, Findlay VJ, Vaena SG, Walsh J, Lewin DN, Turner DP, Watson DK. Slug expression enhances tumor formation in a noninvasive rectal cancer model. J Surg Res. .170(1):56-63, 2011. PMID: 21470622 PMCID: PMC3134530
View in: PubMed

20.Findlay VJ, Turner DP, Yordy JS, McCarragher B, Shriver MR, Szalai G, Watson PM, Larue AC, Moussa O, Watson DK. Prostate-Derived ETS Factor Regulates Epithelial-to-Mesenchymal Transition through Both SLUG-Dependent and Independent Mechanisms. Genes Cancer. .2(2):120-9, 2011. PMID: 21779485 PMCID: PMC3111250
View in: PubMed

21.Moussa O, LaRue AC, Abangan RS, Williams CR, Zhang XK, Masuya M, Gong YZ, Spyropoulos DD, Ogawa M, Gilkeson G, Watson DK. Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. Mol Cell Biol. .30(21):5194-206, 2010. PMID: 20823267 PMCID: PMC2953061
View in: PubMed

22.Mathenia J, Reyes-Cortes E, Williams S, Molano I, Ruiz P, Watson DK, Gilkeson GS, Zhang XK. Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 mice. Clin Exp Immunol. .162(2):362-71, 2010. PMID: 20731671 PMCID: PMC2996603
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23.Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of connective tissues. Exp Hematol. .38(7):540-7, 2010. PMID: 20412832
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24.Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of mesenchymal cells: opportunity for novel therapeutic approaches. Int J Hematol. .91(3):353-9, 2010. PMID: 20336396
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25.Asano Y, Stawski L, Hant F, Highland K, Silver R, Szalai G, Watson DK, Trojanowska M. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol. .176(4):1983-98, 2010. PMID: 20228226 PMCID: PMC2843486
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26.Schaefer JS, Sabherwal Y, Shi HY, Sriraman V, Richards J, Minella A, Turner DP, Watson DK, Zhang M. Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression. J Biol Chem. .285(15):11258-69, 2010. PMID: 20139077 PMCID: PMC2857004
View in: PubMed

27.Moussa O, Turner DP, Feldman RJ, Sementchenko VI, McCarragher BD, Desouki MM, Fraig M, Watson DK. PDEF is a negative regulator of colon cancer cell growth and migration. J Cell Biochem. .108(6):1389-98, 2009. PMID: 19830706 PMCID: PMC3348703
View in: PubMed

28.Shirai K, Sera Y, Bulkeley W, Mehrotra M, Moussa O, LaRue AC, Watson DK, Stuart RK, Lazarchick J, Ogawa M. Hematopoietic stem cell origin of human fibroblasts: cell culture studies of female recipients of gender-mismatched stem cell transplantation and patients with chronic myelogenous leukemia. Exp Hematol. .37(12):1464-71, 2009. PMID: 19786066 PMCID: PMC2802494
View in: PubMed

29.Kruse EA, Loughran SJ, Baldwin TM, Josefsson EC, Ellis S, Watson DK, Nurden P, Metcalf D, Hilton DJ, Alexander WS, Kile BT. Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A. .106(33):13814-9, 2009. PMID: 19666492 PMCID: PMC2728977
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30.Sera Y, LaRue AC, Moussa O, Mehrotra M, Duncan JD, Williams CR, Nishimoto E, Schulte BA, Watson PM, Watson DK, Ogawa M. Hematopoietic stem cell origin of adipocytes. Exp Hematol. .37(9):1108-20, 1120.e1-4, 2009. PMID: 19576951 PMCID: PMC2740899
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31.Elkareh J, Periyasamy SM, Shidyak A, Vetteth S, Schroeder J, Raju V, Hariri IM, El-Okdi N, Gupta S, Fedorova L, Liu J, Fedorova OV, Kahaleh MB, Xie Z, Malhotra D, Watson DK, Bagrov AY, Shapiro JI. Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy. Am J Physiol Renal Physiol. .296(5):F1219-26, 2009. PMID: 19261738 PMCID: PMC2681369
View in: PubMed

32.Asano Y, Markiewicz M, Kubo M, Szalai G, Watson DK, Trojanowska M. Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin. Mol Cell Biol. .29(2):425-34, 2008. PMID: 19001092 PMCID: PMC2612518
View in: PubMed

33.Findlay VJ, Turner DP, Moussa O, Watson DK. MicroRNA-mediated inhibition of prostate-derived Ets factor messenger RNA translation affects prostate-derived Ets factor regulatory networks in human breast cancer. Cancer Res. .68(20):8499-506, 2008. PMID: 18922924 PMCID: PMC2680499
View in: PubMed

34.Zhang XK, Moussa O, LaRue A, Bradshaw S, Molano I, Spyropoulos DD, Gilkeson GS, Watson DK. The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. .181(3):1644-54, 2008. PMID: 18641300 PMCID: PMC2504761
View in: PubMed

35.Turner DP, Findlay VJ, Kirven AD, Moussa O, Watson DK. Global gene expression analysis identifies PDEF transcriptional networks regulating cell migration during cancer progression. Mol Biol Cell. .19(9):3745-57, 2008. PMID: 18579687 PMCID: PMC2526691
View in: PubMed

36.Moussa O, Ashton AW, Fraig M, Garrett-Mayer E, Ghoneim MA, Halushka PV, Watson DK. Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis. Cancer Res. .68(11):4097-104, 2008. PMID: 18519668
View in: PubMed

37.Watson PM, Miller SW, Fraig M, Cole DJ, Watson DK, Boylan AM. CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes. Am J Respir Cell Mol Biol. .38(6):671-8, 2008. PMID: 18218995 PMCID: PMC2396246
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38.Turner DP, Watson DK. ETS transcription factors: oncogenes and tumor suppressor genes as therapeutic targets for prostate cancer. Expert Rev Anticancer Ther. .8(1):33-42, 2008. PMID: 18095881
View in: PubMed

39.Turner DP, Findlay VJ, Moussa O, Watson DK. Defining ETS transcription regulatory networks and their contribution to breast cancer progression. J Cell Biochem. .102(3):549-59, 2007. PMID: 17661355
View in: PubMed

40.Moussa O, Riker JM, Klein J, Fraig M, Halushka PV, Watson DK. Inhibition of thromboxane synthase activity modulates bladder cancer cell responses to chemotherapeutic agents. Oncogene. .27(1):55-62, 2007. PMID: 17603559
View in: PubMed

41.Markiewicz M, Asano Y, Znoyko S, Gong Y, Watson DK, Trojanowska M. Distinct effects of gonadectomy in male and female mice on collagen fibrillogenesis in the skin. J Dermatol Sci. .47(3):217-26, 2007. PMID: 17601707 PMCID: PMC2717737
View in: PubMed

42.Higuchi T, Bartel FO, Masuya M, Deguchi T, Henderson KW, Li R, Muise-Helmericks RC, Kern MJ, Watson DK, Spyropoulos DD. Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice. Mol Cell Biol. .27(9):3353-66, 2007. PMID: 17339335 PMCID: PMC1899970
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43.Turner DP, Moussa O, Sauane M, Fisher PB, Watson DK. Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Cancer Res. .67(4):1618-25, 2007. PMID: 17308102
View in: PubMed

44.Szalai G, LaRue AC, Watson DK. Molecular mechanisms of megakaryopoiesis. Cell Mol Life Sci. .63(21):2460-76, 2006. PMID: 16909203
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45.Pang L, Xue HH, Szalai G, Wang X, Wang Y, Watson DK, Leonard WJ, Blobel GA, Poncz M. Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood. .108(7):2198-206, 2006. PMID: 16757682 PMCID: PMC1895561
View in: PubMed

46.Moussa O, Abol-Enein H, Bissada NK, Keane T, Ghoneim MA, Watson DK. Evaluation of survivin reverse transcriptase-polymerase chain reaction for noninvasive detection of bladder cancer. J Urol. .175(6):2312-6, 2006. PMID: 16697865
View in: PubMed

47.Forough R, Weylie B, Collins C, Parker JL, Zhu J, Barhoumi R, Watson DK. Transcription factor Ets-1 regulates fibroblast growth factor-1-mediated angiogenesis in vivo: role of Ets-1 in the regulation of the PI3K/AKT/MMP-1 pathway. J Vasc Res. .43(4):327-37, 2006. PMID: 16682805
View in: PubMed

48.Moussa O, Yordy JS, Abol-Enein H, Sinha D, Bissada NK, Halushka PV, Ghoneim MA, Watson DK. Prognostic and functional significance of thromboxane synthase gene overexpression in invasive bladder cancer. Cancer Res. .65(24):11581-7, 2005. PMID: 16357168
View in: PubMed

49.Bansal R, Watson DK. Surgical delay in acute admissions on warfarin: are we doing enough? Int J Clin Pract. .59(11):1283-8, 2005. PMID: 16236081
View in: PubMed

50.Yan Y, Rubinchik S, Wood AL, Gillanders WE, Dong JY, Watson DK, Cole DJ. Bystander effect contributes to the antitumor efficacy of CaSm antisense gene therapy in a preclinical model of advanced pancreatic cancer. Mol Ther. .13(2):357-65, 2005. PMID: 16226492
View in: PubMed

51.Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer. .41(16):2462-78, 2005. PMID: 16213704
View in: PubMed

52.Pei H, Li C, Adereth Y, Hsu T, Watson DK, Li R. Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. Cancer Res. .65(16):7205-13, 2005. PMID: 16103071 PMCID: PMC2265436
View in: PubMed

53.Fraser MM, Watson PM, Fraig MM, Kelley JR, Nelson PS, Boylan AM, Cole DJ, Watson DK. CaSm-mediated cellular transformation is associated with altered gene expression and messenger RNA stability. Cancer Res. .65(14):6228-36, 2005. PMID: 16024624
View in: PubMed

54.Yan Y, Rubinchik S, Watson PM, Kelley JR, Fraser MM, Wood AL, Dong JY, Gillanders WE, Boylan AM, Watson DK, Cole DJ. Establishing a murine pancreatic cancer CaSm model: up-regulation of CaSm is required for the transformed phenotype of murine pancreatic adenocarcinoma. Mol Ther. .11(3):363-72, 2005. PMID: 15727932
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55.Zhang XK, Watson DK. The FLI-1 transcription factor is a short-lived phosphoprotein in T cells. J Biochem. .137(3):297-302, 2005. PMID: 15809330
View in: PubMed

56.Yordy JS, Moussa O, Pei H, Chaussabel D, Li R, Watson DK. SP100 inhibits ETS1 activity in primary endothelial cells. Oncogene. .24(5):916-31, 2005. PMID: 15592518
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57.Hsouna A, Watson DK, Hsu T. Developmental expression pattern of D-ets4, the Drosophila homologue of human Pdef. Gene Expr Patterns. .5(2):285-9, 2004. PMID: 15567727
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58.Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC. Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells. J Biol Chem. .280(6):4772-8, 2004. PMID: 15563472
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59.Zhang XK, Gallant S, Molano I, Moussa OM, Ruiz P, Spyropoulos DD, Watson DK, Gilkeson G. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol. .173(10):6481-9, 2004. PMID: 15528390
View in: PubMed

60.Jackers P, Szalai G, Moussa O, Watson DK. Ets-dependent regulation of target gene expression during megakaryopoiesis. J Biol Chem. .279(50):52183-90, 2004. PMID: 15466856
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61.Masuya M, Moussa O, Abe T, Deguchi T, Higuchi T, Ebihara Y, Spyropoulos DD, Watson DK, Ogawa M. Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice. Blood. .105(1):95-102, 2004. PMID: 15367440
View in: PubMed

62.Yordy JS, Li R, Sementchenko VI, Pei H, Muise-Helmericks RC, Watson DK. SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion. Oncogene. .23(39):6654-65, 2004. PMID: 15247905
View in: PubMed

63.Carbone GM, Napoli S, Valentini A, Cavalli F, Watson DK, Catapano CV. Triplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells. Nucleic Acids Res. .32(14):4358-67, 2004. PMID: 15314206 PMCID: PMC514370
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64.Hsu T, Trojanowska M, Watson DK. Ets proteins in biological control and cancer. J Cell Biochem. .91(5):896-903, 2004. PMID: 15034925 PMCID: PMC2265084
View in: PubMed

65.Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith E, Silver RM, Jablonska S, Blaszczyk M, Watson DK, Trojanowska M. Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol. .163(2):571-81, 2003. PMID: 12875977 PMCID: PMC1868228
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66.Feldman RJ, Sementchenko VI, Gayed M, Fraig MM, Watson DK. Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression. Cancer Res. .63(15):4626-31, 2003. PMID: 12907642
View in: PubMed

67.Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R. EAPII interacts with ETS1 and modulates its transcriptional function. Oncogene. .22(18):2699-709, 2003. PMID: 12743594
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68.Chen Y, Wang J, Fraig MM, Henderson K, Bissada NK, Watson DK, Schweinfest CW. Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer. Int J Oncol. .22(5):1033-43, 2003. PMID: 12684669
View in: PubMed

69.Kelley JR, Fraser MM, Hubbard JM, Watson DK, Cole DJ. CaSm antisense gene therapy: a novel approach for the treatment of pancreatic cancer. Anticancer Res. .23(3A):2007-13, 2003. PMID: 12894573
View in: PubMed

70.Spyropoulos DD, Bartel FO, Higuchi T, Deguchi T, Ogawa M, Watson DK. Marker-assisted study of genetic background and gene-targeted locus modifiers in lymphopoietic phenotypes. Anticancer Res. .23(3A):2015-26, 2003. PMID: 12894574
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71.Feldman RJ, Sementchenko VI, Watson DK. The epithelial-specific Ets factors occupy a unique position in defining epithelial proliferation, differentiation and carcinogenesis. Anticancer Res. .23(3A):2125-31, 2003. PMID: 12894586
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72.Czuwara-Ladykowska J, Sementchenko VI, Watson DK, Trojanowska M. Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta. J Biol Chem. .277(23):20399-408, 2002. PMID: 11919190
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73.Kelley JR, Fraser MM, Schweinfest CW, Vournakis JN, Watson DK, Cole DJ. CaSm/gemcitabine chemo-gene therapy leads to prolonged survival in a murine model of pancreatic cancer. Surgery. .130(2):280-8, 2001. PMID: 11490361
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74.Kawada H, Ito T, Pharr PN, Spyropoulos DD, Watson DK, Ogawa M. Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice. Int J Hematol. .73(4):463-8, 2001. PMID: 11503960
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75.Chen Y, Wang J, Fraig MM, Metcalf J, Turner WR, Bissada NK, Watson DK, Schweinfest CW. Defects of DNA mismatch repair in human prostate cancer. Cancer Res. .61(10):4112-21, 2001. PMID: 11358834
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76.Czuwara-Ladykowska J, Shirasaki F, Jackers P, Watson DK, Trojanowska M. Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway. J Biol Chem. .276(24):20839-48, 2001. PMID: 11278621
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77.Li R, Pei H, Watson DK. Regulation of Ets function by protein - protein interactions. Oncogene. .19(55):6514-23, 2000. PMID: 11175367
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78.Sementchenko VI, Watson DK. Ets target genes: past, present and future. Oncogene. .19(55):6533-48, 2000. PMID: 11175369
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79.Spyropoulos DD, Pharr PN, Lavenburg KR, Jackers P, Papas TS, Ogawa M, Watson DK. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol. .20(15):5643-52, 2000. PMID: 10891501 PMCID: PMC86032
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80.Kelley JR, Brown JM, Frasier MM, Baron PL, Schweinfest CW, Vournakis JN, Watson DK, Cole DJ. The cancer-associated Sm-like oncogene: a novel target for the gene therapy of pancreatic cancer. Surgery. .128(2):353-60, 2000. PMID: 10923016
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81.Li R, Pei H, Watson DK, Papas TS. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. Oncogene. .19(6):745-53, 2000. PMID: 10698492
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82.Shirasaki F, Makhluf HA, LeRoy C, Watson DK, Trojanowska M. Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter. Oncogene. .18(54):7755-64, 1999. PMID: 10618716
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83.Schweinfest CW, Graber MW, Chapman JM, Papas TS, Baron PL, Watson DK. CaSm: an Sm-like protein that contributes to the transformed state in cancer cells. Cancer Res. .57(14):2961-5, 1997. PMID: 9230209
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84.Watson DK, McWilliams-Smith MJ, Nunn MF, Duesberg PH, O'Brien SJ, Papas TS. The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active. Proc Natl Acad Sci U S A. .82(21):7294-8, 1985. PMID: 2997781 PMCID: PMC391330
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85.Watson DK, Psallidopoulos MC, Samuel KP, Dalla-Favera R, Papas TS. Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product. Proc Natl Acad Sci U S A. .80(12):3642-5, 1983. PMID: 6304729 PMCID: PMC394106
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86.Reddy EP, Reynolds RK, Watson DK, Schultz RA, Lautenberger J, Papas TS. Nucleotide sequence analysis of the proviral genome of avian myelocytomatosis virus (MC29). Proc Natl Acad Sci U S A. .80(9):2500-4, 1983. PMID: 6302688 PMCID: PMC393853
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87.Watson DK, Reddy EP, Duesberg PH, Papas TS. Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta gag-myc. Proc Natl Acad Sci U S A. .80(8):2146-50, 1983. PMID: 6300896 PMCID: PMC393774
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