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Amanda C LaRue, PhD
Associate Professor of Pathology & Laboratory Medicine
College of Medicine
MUSC

Email: laruerc@musc.edu
 
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Amanda C LaRue, PhD

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Research Interest:

My primary areas of basic science research include hematology/stem cell biology and vascular biology. With regards to stem cell biology, a major focus of my work is directed towards the development of improved methods for the identification, purification, culture and transplantation of hematopoietic stem cells (HSCs). We are currently using this model to investigate the role(s) HSCs in a variety of physiological and pathological systems, including cancer.

Positions:
Associate Director, Flow Cytometry & Cell Sorting Unit, Cell Evaluation & Therapy Shared Resource, Hollings Cancer Center, Medical University of South Carolina

Selected Publications:

1.Guo QJ, Mills JN, Bandurraga SG, Nogueira LM, Mason NJ, Camp ER, Larue AC, Turner DP, Findlay VJ. MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer. Breast Cancer Res. .15(4):R70, 2013.
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2.Ogawa M, LaRue AC, Mehrotra M. Hematopoietic stem cells are pluripotent and not just "hematopoietic". Blood Cells Mol Dis. .51(1):3-8, 2013. PMCID: PMC3646972
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3.Findlay VJ, LaRue AC, Turner DP, Watson PM, Watson DK. Understanding the role of ETS-mediated gene regulation in complex biological processes. Adv Cancer Res. .119:1-61, 2013.
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4.McDonald LT, LaRue AC. Hematopoietic stem cell derived carcinoma-associated fibroblasts: a novel origin. Int J Clin Exp Pathol. .5(9):863-73, 2012. PMCID: PMC3484486
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5.Mehrotra M, Williams CR, Ogawa M, LaRue AC. Hematopoietic stem cells give rise to osteo-chondrogenic cells. Blood Cells Mol Dis. .50(1):41-9, 2012. PMCID: PMC3521579
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6.Turner DP, Findlay VJ, Moussa O, Semenchenko VI, Watson PM, LaRue AC, Desouki MM, Fraig M, Watson DK. Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression. Prostate. .71(16):1723-35, 2011. PMCID: PMC3128180
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7.Findlay VJ, Turner DP, Yordy JS, McCarragher B, Shriver MR, Szalai G, Watson PM, Larue AC, Moussa O, Watson DK. Prostate-Derived ETS Factor Regulates Epithelial-to-Mesenchymal Transition through Both SLUG-Dependent and Independent Mechanisms. Genes Cancer. .2(2):120-9, 2011. PMCID: PMC3111250
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8.Moussa O, LaRue AC, Abangan RS, Williams CR, Zhang XK, Masuya M, Gong YZ, Spyropoulos DD, Ogawa M, Gilkeson G, Watson DK. Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. Mol Cell Biol. .30(21):5194-206, 2010. PMCID: PMC2953061
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9.Jyothi V, Li M, Kilpatrick LA, Smythe N, LaRue AC, Zhou D, Schulte BA, Schmiedt RA, Lang H. Unmyelinated auditory type I spiral ganglion neurons in congenic Ly5.1 mice. J Comp Neurol. .518(16):3254-71, 2010. PMCID: PMC2897057
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10.Mehrotra M, Rosol M, Ogawa M, Larue AC. Amelioration of a mouse model of osteogenesis imperfecta with hematopoietic stem cell transplantation: microcomputed tomography studies. Exp Hematol. .38(7):593-602, 2010. PMCID: PMC2896305
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11.Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of connective tissues. Exp Hematol. .38(7):540-7, 2010.
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12.Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of mesenchymal cells: opportunity for novel therapeutic approaches. Int J Hematol. .91(3):353-9, 2010.
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13.Abangan RS, Williams CR, Mehrotra M, Duncan JD, Larue AC. MCP1 directs trafficking of hematopoietic stem cell-derived fibroblast precursors in solid tumor. Am J Pathol. .176(4):1914-26, 2010. PMCID: PMC2843480
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14.Shirai K, Sera Y, Bulkeley W, Mehrotra M, Moussa O, LaRue AC, Watson DK, Stuart RK, Lazarchick J, Ogawa M. Hematopoietic stem cell origin of human fibroblasts: cell culture studies of female recipients of gender-mismatched stem cell transplantation and patients with chronic myelogenous leukemia. Exp Hematol. .37(12):1464-71, 2009. PMCID: PMC2802494
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15.Sera Y, LaRue AC, Moussa O, Mehrotra M, Duncan JD, Williams CR, Nishimoto E, Schulte BA, Watson PM, Watson DK, Ogawa M. Hematopoietic stem cell origin of adipocytes. Exp Hematol. .37(9):1108-20, 1120.e1-4, 2009. PMCID: PMC2740899
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16.Zhang XK, Moussa O, LaRue A, Bradshaw S, Molano I, Spyropoulos DD, Gilkeson GS, Watson DK. The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. .181(3):1644-54, 2008. PMCID: PMC2504761
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17.Ogawa M, LaRue AC. Origin of fibroblast colony-forming units. Exp Hematol. .35(9):1319-20, 2007.
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18.Szalai G, LaRue AC, Watson DK. Molecular mechanisms of megakaryopoiesis. Cell Mol Life Sci. .63(21):2460-76, 2006.
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19.Ogawa M, LaRue AC, Drake CJ. Hematopoietic origin of fibroblasts/myofibroblasts: Its pathophysiologic implications. Blood. .108(9):2893-6, 2006.
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20.Visconti RP, Ebihara Y, LaRue AC, Fleming PA, McQuinn TC, Masuya M, Minamiguchi H, Markwald RR, Ogawa M, Drake CJ. An in vivo analysis of hematopoietic stem cell potential: hematopoietic origin of cardiac valve interstitial cells. Circ Res. .98(5):690-6, 2006.
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21.Ebihara Y, Masuya M, Larue AC, Fleming PA, Visconti RP, Minamiguchi H, Drake CJ, Ogawa M. Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes. Exp Hematol. .34(2):219-29, 2006.
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22.LaRue AC, Masuya M, Ebihara Y, Fleming PA, Visconti RP, Minamiguchi H, Ogawa M, Drake CJ. Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors. Exp Hematol. .34(2):208-18, 2006.
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23.Wang Y, Schulte BA, LaRue AC, Ogawa M, Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood. .107(1):358-66, 2005. PMCID: PMC1895367
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24.LaRue AC, Argraves WS, Zile MH, Drake CJ. Critical role for retinol in the generation/differentiation of angioblasts required for embryonic blood vessel formation. Dev Dyn. .230(4):666-74, 2004.
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25.Drake CJ, Fleming PA, Larue AC, Barth JL, Chintalapudi MR, Argraves WS. Differential distribution of cubilin and megalin expression in the mouse embryo. Anat Rec A Discov Mol Cell Evol Biol. .277(1):163-70, 2004.
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26.LaRue AC, Lansford R, Drake CJ. Circulating blood island-derived cells contribute to vasculogenesis in the embryo proper. Dev Biol. .262(1):162-72, 2003.
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27.LaRue AC, Mironov VA, Argraves WS, Czirók A, Fleming PA, Drake CJ. Patterning of embryonic blood vessels. Dev Dyn. .228(1):21-9, 2003.
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28.Argraves WS, Larue AC, Fleming PA, Drake CJ. VEGF signaling is required for the assembly but not the maintenance of embryonic blood vessels. Dev Dyn. .225(3):298-304, 2002.
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29.Drake CJ, LaRue A, Ferrara N, Little CD. VEGF regulates cell behavior during vasculogenesis. Dev Biol. .224(2):178-88, 2000.
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