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Amanda C LaRue, PhD
Associate Professor of Pathology & Laboratory Medicine
College of Medicine
MUSC

Email: laruerc@musc.edu
 
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Amanda C LaRue, PhD

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Research Interest:

My primary areas of basic science research include hematology/stem cell biology and vascular biology. With regards to stem cell biology, a major focus of my work is directed towards the development of improved methods for the identification, purification, culture and transplantation of hematopoietic stem cells (HSCs). We are currently using this model to investigate the role(s) HSCs in a variety of physiological and pathological systems, including cancer.

Positions:
Associate Director, Flow Cytometry & Cell Sorting Unit, Cell Evaluation & Therapy Shared Resource, Hollings Cancer Center, Medical University of South Carolina
Acting Associate Chief of Staff for Research & Development, Ralph H. Johnson VA Medical Center

Selected Publications:

1.An N, Xiong Y, LaRue AC, Kraft AS, Cen B. Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors. Cancer Res. .75(24):5318-28, 2015. PMID: 26670562 PMCID: PMC4683614
View in: PubMed

2.Ogawa M, LaRue AC, Mehrotra M. Plasticity of hematopoietic stem cells. Best Pract Res Clin Haematol. .28(2-3):73-80, 2015. PMID: 26590762
View in: PubMed

3.Yang A, Xiao X, Zhao M, LaRue AC, Schulte BA, Wang GY. Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition. Stem Cells Int. .2015:561404, 2015. PMID: 26221145 PMCID: PMC4499403
View in: PubMed

4.McDonald LT, Mehrotra M, LaRue AC. Hematopoietic Origin of Murine Lung Fibroblasts. Stem Cells Int. .2015:159713, 2015. PMID: 26185498 PMCID: PMC4491389
View in: PubMed

5.McDonald LT, Russell DL, Kelly RR, Xiong Y, Motamarry A, Patel RK, Jones JA, Watson PM, Turner DP, Watson DK, Soloff AC, Findlay VJ, LaRue AC. Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment. Neoplasia. .17(5):434-48, 2015. PMID: 26025666 PMCID: PMC4468366
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6.Xiong Y, McDonald LT, Russell DL, Kelly RR, Wilson KR, Mehrotra M, Soloff AC, LaRue AC. Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment. World J Stem Cells. .7(2):253-65, 2015. PMID: 25815113 PMCID: PMC4369485
View in: PubMed

7.Xiao X, Luo H, Vanek KN, LaRue AC, Schulte BA, Wang GY. Catalase inhibits ionizing radiation-induced apoptosis in hematopoietic stem and progenitor cells. Stem Cells Dev. .24(11):1342-51, 2015. PMID: 25603016 PMCID: PMC4440990
View in: PubMed

8.Cen B, Xiong Y, Song JH, Mahajan S, DuPont R, McEachern K, DeAngelo DJ, Cortes JE, Minden MD, Ebens A, Mims A, LaRue AC, Kraft AS. The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol. .34(13):2517-32, 2014. PMID: 24777602 PMCID: PMC4054323
View in: PubMed

9.Ogawa M, LaRue AC, Mehrotra M. Hematopoietic stem cells are pluripotent and not just "hematopoietic". Blood Cells Mol Dis. .51(1):3-8, 2013. PMID: 23453528 PMCID: PMC3646972
View in: PubMed

10.Findlay VJ, LaRue AC, Turner DP, Watson PM, Watson DK. Understanding the role of ETS-mediated gene regulation in complex biological processes. Adv Cancer Res. .119:1-61, 2013. PMID: 23870508
View in: PubMed

11.Guo QJ, Mills JN, Bandurraga SG, Nogueira LM, Mason NJ, Camp ER, Larue AC, Turner DP, Findlay VJ. MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer. Breast Cancer Res. .15(4):R70, 2013. PMID: 23971998 PMCID: PMC3978419
View in: PubMed

12.McDonald LT, LaRue AC. Hematopoietic stem cell derived carcinoma-associated fibroblasts: a novel origin. Int J Clin Exp Pathol. .5(9):863-73, 2012. PMID: 23119103 PMCID: PMC3484486
View in: PubMed

13.Mehrotra M, Williams CR, Ogawa M, LaRue AC. Hematopoietic stem cells give rise to osteo-chondrogenic cells. Blood Cells Mol Dis. .50(1):41-9, 2012. PMID: 22954476 PMCID: PMC3521579
View in: PubMed

14.Turner DP, Findlay VJ, Moussa O, Semenchenko VI, Watson PM, LaRue AC, Desouki MM, Fraig M, Watson DK. Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression. Prostate. .71(16):1723-35, 2011. PMID: 21446014 PMCID: PMC3128180
View in: PubMed

15.Findlay VJ, Turner DP, Yordy JS, McCarragher B, Shriver MR, Szalai G, Watson PM, Larue AC, Moussa O, Watson DK. Prostate-Derived ETS Factor Regulates Epithelial-to-Mesenchymal Transition through Both SLUG-Dependent and Independent Mechanisms. Genes Cancer. .2(2):120-9, 2011. PMID: 21779485 PMCID: PMC3111250
View in: PubMed

16.Moussa O, LaRue AC, Abangan RS, Williams CR, Zhang XK, Masuya M, Gong YZ, Spyropoulos DD, Ogawa M, Gilkeson G, Watson DK. Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. Mol Cell Biol. .30(21):5194-206, 2010. PMID: 20823267 PMCID: PMC2953061
View in: PubMed

17.Jyothi V, Li M, Kilpatrick LA, Smythe N, LaRue AC, Zhou D, Schulte BA, Schmiedt RA, Lang H. Unmyelinated auditory type I spiral ganglion neurons in congenic Ly5.1 mice. J Comp Neurol. .518(16):3254-71, 2010. PMID: 20575058 PMCID: PMC2897057
View in: PubMed

18.Mehrotra M, Rosol M, Ogawa M, Larue AC. Amelioration of a mouse model of osteogenesis imperfecta with hematopoietic stem cell transplantation: microcomputed tomography studies. Exp Hematol. .38(7):593-602, 2010. PMID: 20417683 PMCID: PMC2896305
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19.Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of connective tissues. Exp Hematol. .38(7):540-7, 2010. PMID: 20412832
View in: PubMed

20.Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of mesenchymal cells: opportunity for novel therapeutic approaches. Int J Hematol. .91(3):353-9, 2010. PMID: 20336396
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21.Abangan RS, Williams CR, Mehrotra M, Duncan JD, Larue AC. MCP1 directs trafficking of hematopoietic stem cell-derived fibroblast precursors in solid tumor. Am J Pathol. .176(4):1914-26, 2010. PMID: 20167869 PMCID: PMC2843480
View in: PubMed

22.Shirai K, Sera Y, Bulkeley W, Mehrotra M, Moussa O, LaRue AC, Watson DK, Stuart RK, Lazarchick J, Ogawa M. Hematopoietic stem cell origin of human fibroblasts: cell culture studies of female recipients of gender-mismatched stem cell transplantation and patients with chronic myelogenous leukemia. Exp Hematol. .37(12):1464-71, 2009. PMID: 19786066 PMCID: PMC2802494
View in: PubMed

23.Sera Y, LaRue AC, Moussa O, Mehrotra M, Duncan JD, Williams CR, Nishimoto E, Schulte BA, Watson PM, Watson DK, Ogawa M. Hematopoietic stem cell origin of adipocytes. Exp Hematol. .37(9):1108-20, 1120.e1-4, 2009. PMID: 19576951 PMCID: PMC2740899
View in: PubMed

24.Zhang XK, Moussa O, LaRue A, Bradshaw S, Molano I, Spyropoulos DD, Gilkeson GS, Watson DK. The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. .181(3):1644-54, 2008. PMID: 18641300 PMCID: PMC2504761
View in: PubMed

25.Ogawa M, LaRue AC. Origin of fibroblast colony-forming units. Exp Hematol. .35(9):1319-20, 2007. PMID: 17637495
View in: PubMed

26.Szalai G, LaRue AC, Watson DK. Molecular mechanisms of megakaryopoiesis. Cell Mol Life Sci. .63(21):2460-76, 2006. PMID: 16909203
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27.Ogawa M, LaRue AC, Drake CJ. Hematopoietic origin of fibroblasts/myofibroblasts: Its pathophysiologic implications. Blood. .108(9):2893-6, 2006. PMID: 16840726
View in: PubMed

28.Visconti RP, Ebihara Y, LaRue AC, Fleming PA, McQuinn TC, Masuya M, Minamiguchi H, Markwald RR, Ogawa M, Drake CJ. An in vivo analysis of hematopoietic stem cell potential: hematopoietic origin of cardiac valve interstitial cells. Circ Res. .98(5):690-6, 2006. PMID: 16456103
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29.LaRue AC, Masuya M, Ebihara Y, Fleming PA, Visconti RP, Minamiguchi H, Ogawa M, Drake CJ. Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors. Exp Hematol. .34(2):208-18, 2006. PMID: 16459189
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30.Ebihara Y, Masuya M, Larue AC, Fleming PA, Visconti RP, Minamiguchi H, Drake CJ, Ogawa M. Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes. Exp Hematol. .34(2):219-29, 2006. PMID: 16459190
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31.Wang Y, Schulte BA, LaRue AC, Ogawa M, Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood. .107(1):358-66, 2005. PMID: 16150936 PMCID: PMC1895367
View in: PubMed

32.LaRue AC, Argraves WS, Zile MH, Drake CJ. Critical role for retinol in the generation/differentiation of angioblasts required for embryonic blood vessel formation. Dev Dyn. .230(4):666-74, 2004. PMID: 15254901
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33.Drake CJ, Fleming PA, Larue AC, Barth JL, Chintalapudi MR, Argraves WS. Differential distribution of cubilin and megalin expression in the mouse embryo. Anat Rec A Discov Mol Cell Evol Biol. .277(1):163-70, 2004. PMID: 14983511
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34.LaRue AC, Lansford R, Drake CJ. Circulating blood island-derived cells contribute to vasculogenesis in the embryo proper. Dev Biol. .262(1):162-72, 2003. PMID: 14512026
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35.LaRue AC, Mironov VA, Argraves WS, Czirók A, Fleming PA, Drake CJ. Patterning of embryonic blood vessels. Dev Dyn. .228(1):21-9, 2003. PMID: 12950076
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36.Argraves WS, Larue AC, Fleming PA, Drake CJ. VEGF signaling is required for the assembly but not the maintenance of embryonic blood vessels. Dev Dyn. .225(3):298-304, 2002. PMID: 12412012
View in: PubMed

37.Drake CJ, LaRue A, Ferrara N, Little CD. VEGF regulates cell behavior during vasculogenesis. Dev Biol. .224(2):178-88, 2000. PMID: 10926758
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