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Terrence A Day, MD
Professor of Otolaryngology
College of Medicine
MUSC

Email: dayt@musc.edu
 
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Terrence A Day, MD

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Research Interest:

My clinical research interests involve the development of novel molecular targeting in head and neck cancer through collaboration in the area of cancer microenvironment, cancer immunology, developmental therapeutics, and cancer control. I have led several clinical trials as Principal Investigator and am currently the MUSC HCC Institutional PI in the use of an mTOR induction therapy in head and neck squamous cell carcinoma. My work in the cancer prevention and control areas has been ongoing for the past ten years working as a board member with the Head and Neck Cancer Alliance, Inc. and many other organizations to increase education and awareness related to head and neck cancer.

Selected Publications:

1.Rachidi S, Wallace K, Day TA, Alberg AJ, Li Z. Lower circulating platelet count and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma. J Hematol Oncol. .7(1):65, 2014. PMCID: PMC4189675
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2.Stokes WA, Fuller C, Day TA, Gillespie MB. Perioperative survival of elderly head and neck squamous cell carcinoma patients. Laryngoscope. .124(10):2281-6, 2014.
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3.Day TA. The Ultimate Constant of Head and Neck Oncology-The Physician-Patient Relationship: JAMA Otolaryngol Head Neck Surg. .1-7, 2014.
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4.Luryi AL, Yarbrough WG, Niccolai LM, Roser S, Reed SG, Nathan CA, Moore MG, Day T, Judson BL. Public awareness of head and neck cancers: a cross-sectional survey. JAMA Otolaryngol Head Neck Surg. .140(7):639-46, 2014.
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5.McIlwain WR, Sood AJ, Nguyen SA, Day TA. Initial symptoms in patients with HPV-positive and HPV-negative oropharyngeal cancer. JAMA Otolaryngol Head Neck Surg. .140(5):441-7, 2014.
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6.Lohia S, Rajapurkar M, Nguyen SA, Sharma AK, Gillespie MB, Day TA. A comparison of outcomes using intensity-modulated radiation therapy and 3-dimensional conformal radiation therapy in treatment of oropharyngeal cancer. JAMA Otolaryngol Head Neck Surg. .140(4):331-7, 2014.
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7.Fuller C, Camilon R, Nguyen S, Jennings J, Day T, Gillespie MB. Adjunctive diagnostic techniques for oral lesions of unknown malignant potential: Systematic review with meta-analysis. Head Neck. ., 2014.
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8.Lovelace TL, Fox NF, Sood AJ, Nguyen SA, Day TA. Management of radiotherapy-induced salivary hypofunction and consequent xerostomia in patients with oral or head and neck cancer: meta-analysis and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol. .117(5):595-607, 2014.
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9.Sood AJ, McIlwain W, O'Connell B, Nguyen S, Houlton JJ, Day T. The association between T-stage and clinical nodal metastasis In HPV-positive oropharyngeal cancer. Am J Otolaryngol. .35(4):463-8, 2013.
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10.Sood AJ, Fox NF, O'Connell BP, Lovelace TL, Nguyen SA, Sharma AK, Hornig JD, Day TA. Salivary gland transfer to prevent radiation-induced xerostomia: a systematic review and meta-analysis. Oral Oncol. .50(2):77-83, 2013.
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11.Young MR, Day TA. Immune regulatory activity of vitamin d3 in head and neck cancer. Cancers (Basel). .5(3):1072-85, 2013. PMCID: PMC3795379
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12.Robinson JC, Richardson MS, Neville BW, Day TA, Chi AC. Sclerosing rhabdomyosarcoma: report of a case arising in the head and neck of an adult and review of the literature. Head Neck Pathol. .7(2):193-202, 2012. PMCID: PMC3642263
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13.Nguyen SA, Walker D, Gillespie MB, Gutkind JS, Day TA. mTOR inhibitors and its role in the treatment of head and neck squamous cell carcinoma. Curr Treat Options Oncol. .13(1):71-81, 2012.
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14.Byrd JK, Yawn RJ, Wilhoit CS, Sora ND, Meyers L, Fernandes J, Day T. Well differentiated thyroid carcinoma: current treatment. Curr Treat Options Oncol. .13(1):47-57, 2012.
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15.Cannon TY, Strub GM, Yawn RJ, Day TA. Oromandibular reconstruction. Clin Anat. .25(1):108-19, 2012.
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16.Banks CA, Ayers CM, Hornig JD, Lentsch EJ, Day TA, Nguyen SA, Gillespie MB. Thyroid disease and compressive symptoms. Laryngoscope. .122(1):13-6, 2011.
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17.Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C18-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. .17(18):6097-105, 2011. PMCID: PMC3176980
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18.Gillespie MB, Stachiw ND, Way J, Lentsch EJ, Richardson MS, Nguyen SA, Day TA, Hornig JD. Neural outcomes after plasma knife dissection: a pathologic study and clinical correlation. Head Neck. .32(10):1321-7, 2010.
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19.Reed SG, Cartmell KB, Duffy NG, Wahlquist AE, Sinha D, Hollinger A, Bode A, Alberg AJ, Day TA. Oral cancer preventive practices of South Carolina dentists and physicians. J Cancer Educ. .25(2):166-73, 2010.
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20.Day TA, Koch M, Nouailles G, Jacobsen M, Kosmiadi GA, Miekley D, Kuhlmann S, Jörg S, Gamradt P, Mollenkopf HJ, Hurwitz R, Reece ST, Kaufmann SH, Kursar M. Secondary lymphoid organs are dispensable for the development of T-cell-mediated immunity during tuberculosis. Eur J Immunol. .40(6):1663-73, 2010.
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21.Walsh JE, Clark AM, Day TA, Gillespie MB, Young MR. Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma. Hum Immunol. .71(7):659-65, 2010. PMCID: PMC3337687
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22.Brodsky MB, McFarland DH, Dozier TS, Blair J, Ayers C, Michel Y, Gillespie MB, Day TA, Martin-Harris B. Respiratory-swallow phase patterns and their relationship to swallowing impairment in patients treated for oropharyngeal cancer. Head Neck. .32(4):481-9, 2010. PMCID: PMC3482835
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23.Watkins JM, Zauls AJ, Wahlquist AH, Shirai K, Garrett-Mayer E, Gillespie MB, Day TA, Sharma AK. Low-dose weekly platinum-based chemoradiation for advanced head and neck cancer. Laryngoscope. .120(2):236-42, 2010.
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24.Harvey RJ, Pitzer G, Nissman DB, Buchmann L, Rumboldt Z, Day T, Schlosser RJ. PET/CT in the assessment of previously treated skull base malignancies. Head Neck. .32(1):76-84, 2010.
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25.Gillespie MB, Dozier TS, Day TA, Martin-Harris B, Nguyen SA. Effectiveness of calcium hydroxylapatite paste in vocal rehabilitation. Ann Otol Rhinol Laryngol. .118(8):546-51, 2009.
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26.Yuen HK, Logan WC, Boyd MG, Day TA, Brooks JO. Negative psychosocial consequence of self-restricted driving among cancer survivors in the head and neck region. Clin Otolaryngol. .34(4):395-6, 2009.
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27.Clyburn VL, Smith JE, Rumboldt T, Matheus MG, Day TA. Ascending and plunging ranula in a pediatric patient. Otolaryngol Head Neck Surg. .140(6):948-9, 2009.
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28.Watkins JM, Shirai KS, Wahlquist AE, Stuart RK, Chaudhary UB, Garrett-Mayer E, Day TA, Gillespie MB, Sharma AK. Toxicity and survival outcomes of hyperfractionated split-course reirradiation and daily concurrent chemotherapy in locoregionally recurrent, previously irradiated head and neck cancers. Head Neck. .31(4):493-502, 2009.
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29.Mulligan JK, Day TA, Gillespie MB, Rosenzweig SA, Young MR. Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions. Hum Immunol. .70(6):375-82, 2009. PMCID: PMC2746465
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30.Kulbersh JS, Day TA, Gillespie MB, Young MR. 1alpha,25-Dihydroxyvitamin D(3) to skew intratumoral levels of immune inhibitory CD34(+) progenitor cells into dendritic cells. Otolaryngol Head Neck Surg. .140(2):235-40, 2009. PMCID: PMC3337726
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31.Gillespie MB, Smith J, Gibbs K, McRackan T, Rubinchik S, Day TA, Sutkowski N. Human papillomavirus and head and neck cancer: a growing concern. J S C Med Assoc. .104(8):247-51, 2008.
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32.Bisdas S, Nguyen SA, Anand SK, Glavina G, Day T, Rumboldt Z. Outcome prediction after surgery and chemoradiation of squamous cell carcinoma in the oral cavity, oropharynx, and hypopharynx: use of baseline perfusion CT microcirculatory parameters vs. tumor volume. Int J Radiat Oncol Biol Phys. .73(5):1313-8, 2008.
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33.McRackan TR, Watkins JM, Herrin AE, Garrett-Mayer EM, Sharma AK, Day TA, Gillespie MB. Effect of body mass index on chemoradiation outcomes in head and neck cancer. Laryngoscope. .118(7):1180-5, 2008.
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34.Vu KN, Day TA, Gillespie MB, Martin-Harris B, Sinha D, Stuart RK, Sharma AK. Proximal esophageal stenosis in head and neck cancer patients after total laryngectomy and radiation. ORL J Otorhinolaryngol Relat Spec. .70(4):229-35, 2008.
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35.Yuen HK, Sharma AK, Logan WC, Gillespie MB, Day TA, Brooks JO. Radiation dose, driving performance, and cognitive function in patients with head and neck cancer. Radiother Oncol. .87(2):304-7, 2008.
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36.Robbins KT, Shaha AR, Medina JE, Califano JA, Wolf GT, Ferlito A, Som PM, Day TA. Consensus statement on the classification and terminology of neck dissection. Arch Otolaryngol Head Neck Surg. .134(5):536-8, 2008.
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37.Watkins JM, Stuart RK, Davis BK, Day TA, Chaudharry UB, Sharma AK. Long-term survival following salvage reirradiation with concurrent chemotherapy for recurrent head and neck cancer. J S C Med Assoc. .104(2):36-9, 2008.
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38.Leach BC, Kulbersh JS, Day TA, Cook J. Cranial neuropathy as a presenting sign of recurrent aggressive skin cancer. Dermatol Surg. .34(4):483-97, 2008.
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39.Szekeres PG, Leong K, Day TA, Kingston AE, Karran EH. Development of homogeneous 384-well high-throughput screening assays for Abeta1-40 and Abeta1-42 using AlphaScreen technology. J Biomol Screen. .13(2):101-11, 2008.
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40.Yuen HK, Gillespie MB, Barkley RA, Day TA, Bandyopadhyay D, Sharma AK. Driving performance in patients with cancer in the head and neck region: a pilot study. Arch Otolaryngol Head Neck Surg. .133(9):904-9, 2007.
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41.Cannick GF, Horowitz AM, Garr DR, Reed SG, Neville BW, Day TA, Woolson RF, Lackland DT. Use of the OSCE to evaluate brief communication skills training for dental students. J Dent Educ. .71(9):1203-9, 2007. PMCID: PMC2712283
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42.Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett. .256(1):101-11, 2007. PMCID: PMC2084356
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43.Yuen HK, Gillespie MB, Day TA, Morgan L, Burik JK. Driving behaviors in patients with head and neck cancer during and after cancer treatment: a preliminary report. Head Neck. .29(7):675-81, 2007.
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44.Walsh JE, Lathers DM, Chi AC, Gillespie MB, Day TA, Young MR. Mechanisms of tumor growth and metastasis in head and neck squamous cell carcinoma. Curr Treat Options Oncol. .8(3):227-38, 2007.
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45.Elojeimy S, Liu X, McKillop JC, El-Zawahry AM, Holman DH, Cheng JY, Meacham WD, Mahdy AE, Saad AF, Turner LS, Cheng J, A Day T, Dong JY, Bielawska A, Hannun YA, Norris JS. Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther. .15(7):1259-63, 2007.
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46.Young MR, Neville BW, Chi AC, Lathers DM, Gillespie MB, Day TA. Autocrine motility-stimulatory pathways of oral premalignant lesion cells. Clin Exp Metastasis. .24(2):131-9, 2007.
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47.Cornett WR, Sharma AK, Day TA, Richardson MS, Hoda RS, van Heerden JA, Fernandes JK. Anaplastic thyroid carcinoma: an overview. Curr Oncol Rep. .9(2):152-8, 2007.
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48.Gillespie MB, Moody MW, Lee FS, Poole LJ, Hornig JD, Lathers D, Young MR, Day TA. Head and neck cancer recurrence and mortality in nonselective cyclooxygenase inhibitor users. Arch Otolaryngol Head Neck Surg. .133(1):28-31, 2007.
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49.Gillespie MB, Day TA, Sharma AK, Brodsky MB, Martin-Harris B. Role of mitomycin in upper digestive tract stricture. Head Neck. .29(1):12-7, 2007.
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50.Cannick GF, Horowitz AM, Garr DR, Reed SG, Neville BW, Day TA, Woolson RF, Lackland DT. Oral cancer prevention and early detection: using the PRECEDE-PROCEED framework to guide the training of health professional students. J Cancer Educ. .22(4):250-3, 2007.
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51.Young MR, Neville BW, Chi AC, Lathers DM, Boyd Gillespie M, Day TA. Oral premalignant lesions induce immune reactivity to both premalignant oral lesions and head and neck squamous cell carcinoma. Cancer Immunol Immunother. .56(7):1077-86, 2006.
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52.Slomiany MG, Black LA, Kibbey MM, Tingler MA, Day TA, Rosenzweig SA. Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma. Cancer Lett. .248(2):269-79, 2006.
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53.Yen KL, Horner MJ, Reed SG, Daguise VG, Bolick-Aldrich SW, Young MR, Day TA, Wood PA, Hebert JR. Head and neck cancer disparities in South Carolina: descriptive epidemiology, early detection, and special programs. J S C Med Assoc. .102(7):192-200, 2006.
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54.Rumboldt Z, Day TA, Michel M. Imaging of oral cavity cancer. Oral Oncol. .42(9):854-65, 2006.
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55.ElOjeimy S, McKillop JC, El-Zawahry AM, Holman DH, Liu X, Schwartz DA, Day TA, Dong JY, Norris JS. FasL gene therapy: a new therapeutic modality for head and neck cancer. Cancer Gene Ther. .13(8):739-45, 2006.
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56.Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther. .317(3):1188-99, 2006.
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57.Slomiany MG, Black LA, Kibbey MM, Day TA, Rosenzweig SA. IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma. Biochem Biophys Res Commun. .342(3):851-8, 2006.
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58.Schlosser RJ, Woodworth BA, Gillespie MB, Day TA. Endoscopic resection of sinonasal hemangiomas and hemangiopericytomas. ORL J Otorhinolaryngol Relat Spec. .68(2):69-72, 2006.
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59.Gillespie MB, Marshall DT, Day TA, Mitchell AO, White DR, Barredo JC. Pediatric rhabdomyosarcoma of the head and neck. Curr Treat Options Oncol. .7(1):13-22, 2006.
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60.Cannick GF, Horowitz AM, Reed SG, Drury TF, Day TA. Opinions of South Carolina dental students toward tobacco use interventions. J Public Health Dent. .66(1):44-8, 2006.
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61.Rapidis AD, Day TA. The use of temporal polyethylene implant after temporalis myofascial flap transposition: clinical and radiographic results from its use in 21 patients. J Oral Maxillofac Surg. .64(1):12-22, 2006.
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62.Miller PM, Day TA, Ravenel MC. Clinical implications of continued alcohol consumption after diagnosis of upper aerodigestive tract cancer. Alcohol Alcohol. .41(2):140-2, 2005.
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63.Gillespie MB, Brodsky MB, Day TA, Sharma AK, Lee FS, Martin-Harris B. Laryngeal penetration and aspiration during swallowing after the treatment of advanced oropharyngeal cancer. Arch Otolaryngol Head Neck Surg. .131(7):615-9, 2005.
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64.Cannick GF, Horowitz AM, Drury TF, Reed SG, Day TA. Assessing oral cancer knowledge among dental students in South Carolina. J Am Dent Assoc. .136(3):373-8, 2005.
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65.Day TA, Chi A, Neville B, Hebert JR. Prevention of head and neck cancer. Curr Oncol Rep. .7(2):145-53, 2005.
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66.Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B. Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg. .132(1):55-62, 2005.
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67.Fernandes JK, Day TA, Richardson MS, Sharma AK. Overview of the management of differentiated thyroid cancer. Curr Treat Options Oncol. .6(1):47-57, 2005.
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68.Day TA, Beas RA, Schlosser RJ, Woodworth BA, Barredo J, Sharma AK, Gillespie MB. Management of paranasal sinus malignancy. Curr Treat Options Oncol. .6(1):3-18, 2005.
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69.Reed SG, Duffy NG, Walters KC, Day TA. Oral cancer knowledge and experience: a survey of South Carolina medical students in 2002. J Cancer Educ. .20(3):136-42, 2005.
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70.Day TA, Hornig JD, Sharma AK, Brescia F, Gillespie MB, Lathers D. Melanoma of the head and neck. Curr Treat Options Oncol. .6(1):19-30, 2005.
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71.Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem. .279(43):44311-9, 2004.
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72.Gillespie MB, Brodsky MB, Day TA, Lee FS, Martin-Harris B. Swallowing-related quality of life after head and neck cancer treatment. Laryngoscope. .114(8):1362-7, 2004.
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73.Wildi SM, Fickling WE, Day TA, Cunningham CD, Schmulewitz N, Varadarajulu S, Roberts SS, Ferguson B, Hoffman BJ, Hawes RH, Wallace MB. Endoscopic ultrasonography in the diagnosis and staging of neoplasms of the head and neck. Endoscopy. .36(7):624-30, 2004.
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74.Day TA, Deveikis J, Gillespie MB, Joe JK, Ogretmen B, Osguthorpe JD, Reed SG, Richardson MS, Rossi M, Saini R, Sharma AK, Stuart RK. Salivary gland neoplasms. Curr Treat Options Oncol. .5(1):11-26, 2004.
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75.Scarbrough TJ, Day TA, Williams TE, Hardin JH, Aguero EG, Thomas CR. Referred otalgia in head and neck cancer: a unifying schema. Am J Clin Oncol. .26(5):e157-62, 2003.
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76.Day TA, Davis BK, Gillespie MB, Joe JK, Kibbey M, Martin-Harris B, Neville B, Richardson MS, Rosenzweig S, Sharma AK, Smith MM, Stewart S, Stuart RK. Oral cancer treatment. Curr Treat Options Oncol. .4(1):27-41, 2003.
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77.Day TA, Chu A, Hoang KG. Multinodular goiter. Otolaryngol Clin North Am. .36(1):35-54, 2003.
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78.Teknos TN, Smith JC, Day TA, Netterville JL, Burkey BB. Microvascular free tissue transfer in reconstructing skull base defects: lessons learned. Laryngoscope. .112(10):1871-6, 2002.
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79.Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. .52(4):195-215, 2002.
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80.Coleman SC, Stewart ZA, Day TA, Netterville JL, Burkey BB, Pietenpol JA. Analysis of cell-cycle checkpoint pathways in head and neck cancer cell lines: implications for therapeutic strategies. Arch Otolaryngol Head Neck Surg. .128(2):167-76, 2002.
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81.Coleman SC, Burkey BB, Day TA, Resser JR, Netterville JL, Dauer E, Sutinis E. Increasing use of the scapula osteocutaneous free flap. Laryngoscope. .110(9):1419-24, 2000.
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82.Coleman SC, Smith JC, Burkey BB, Day TA, Page RN, Netterville JL. Long-standing lateral neck mass as the initial manifestation of well-differentiated thyroid carcinoma. Laryngoscope. .110(2 Pt 1):204-9, 2000.
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83.Day TA, Tarr C, Zealear D, Burkey BB, Sullivan CA. Tongue replantation in an animal model. Microsurgery. .20(3):105-8, 2000.
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