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Kevin M Gray, MD
Associate Professor of Psychiatry & Behavioral Sciences
College of Medicine
MUSC

Email: graykm@musc.edu
 
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Kevin M Gray, MD

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Research Interest:

I am a board-certified child and adolescent psychiatrist with an interest in substance initiation and progression to abuse during adolescence. I was one of only five candidates selected to participate in the American Academy of Child and Adolescent Psychiatry/National Institute on Drug Abuse Physician Scientist in Substance Abuse K12 research training program. As part of my participation in that program, I conducted three novel investigations among adolescent marijuana users: 1) a marijuana cue reactivity study; 2) a laboratory study of dronabinol (oral THC); and 3) a pilot clinical trial of N-acetylcysteine. I have since initiated a randomized trial of N-acetylcysteine as a treatment for cannabis dependence in adolescents. I also conduct investigations focusing on nicotine dependence. I recently completed a large-scale randomized trial of bupropion SR and contingency management in nicotine-dependent adolescents, and a pilot trial of varenicline and bupropion XL in adolescent smokers. I am also investigating menstrual cycle effects on craving and cessation treatment among women smokers.

Selected Publications:

1.McClure EA, Gipson CD, Malcolm RJ, Kalivas PW, Gray KM. Potential Role of N-Acetylcysteine in the Management of Substance Use Disorders. CNS Drugs. ., 2014.
View in: PubMed

2.Milsom VA, Malcolm RJ, Johnson GC, Pechon SM, Gray KM, Miller-Kovach K, Rost SL, O'Neil PM. Changes in cardiovascular risk factors with participation in a 12-week weight loss trial using a commercial format. Eat Behav. .15(1):68-71, 2013.
View in: PubMed

3.Burris JL, Carpenter MJ, Wahlquist AE, Cummings KM, Gray KM. Brief, Instructional Smokeless Tobacco Use Among Cigarette Smokers Who Do Not Intend to Quit: A Pilot Randomized Clinical Trial. Nicotine Tob Res. ., 2013.
View in: PubMed

4.Carpenter MJ, Saladin ME, Larowe SD, McClure EA, Simonian S, Upadhyaya HP, Gray KM. Craving, cue reactivity, and stimulus control among early-stage young smokers: effects of smoking intensity and gender. Nicotine Tob Res. .16(2):208-15, 2013. PMCID: PMC3880235
View in: PubMed

5.McClure EA, Saladin ME, Baker NL, Carpenter MJ, Gray KM. Smoking topography and abstinence in adult female smokers. Addict Behav. .38(12):2833-6, 2013. PMCID: PMC3805754
View in: PubMed

6.Lewis AL, Baker N, Carpenter M, Klintworth E, Gray KM. Does physician continuity within a clinical trial increase retention and compliance among adolescent smokers? Adolesc Psychiatry (Hilversum). .3(2), 2013. PMCID: PMC3857140
View in: PubMed

7.Saladin ME, Gray KM, McRae-Clark AL, Larowe SD, Yeatts SD, Baker NL, Hartwell KJ, Brady KT. A double blind, placebo-controlled study of the effects of post-retrieval propranolol on reconsolidation of memory for craving and cue reactivity in cocaine dependent humans. Psychopharmacology (Berl). .226(4):721-37, 2013. PMCID: PMC3637960
View in: PubMed

8.Hartwell KJ, Lematty T, McRae-Clark AL, Gray KM, George MS, Brady KT. Resisting the urge to smoke and craving during a smoking quit attempt on varenicline: results from a pilot fMRI study. Am J Drug Alcohol Abuse. .39(2):92-8, 2013.
View in: PubMed

9.Thrasher JF, Carpenter MJ, Andrews JO, Gray KM, Alberg AJ, Navarro A, Friedman DB, Cummings KM. Cigarette warning label policy alternatives and smoking-related health disparities. Am J Prev Med. .43(6):590-600, 2012. PMCID: PMC3504356
View in: PubMed

10.Roten AT, Baker NL, Gray KM. Marijuana craving trajectories in an adolescent marijuana cessation pharmacotherapy trial. Addict Behav. .38(3):1788-91, 2012. PMCID: PMC3558535
View in: PubMed

11.Gray KM, Carpenter MJ, Baker NL, DeSantis SM, Kryway E, Hartwell KJ, McRae-Clark AL, Brady KT. A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. Am J Psychiatry. .169(8):805-12, 2012. PMCID: PMC3410961
View in: PubMed

12.Saladin ME, Gray KM, Carpenter MJ, LaRowe SD, DeSantis SM, Upadhyaya HP. Gender differences in craving and cue reactivity to smoking and negative affect/stress cues. Am J Addict. .21(3):210-20, 2012. PMCID: PMC3325498
View in: PubMed

13.Schiller CE, Saladin ME, Gray KM, Hartwell KJ, Carpenter MJ. Association between ovarian hormones and smoking behavior in women. Exp Clin Psychopharmacol. .20(4):251-7, 2012. PMCID: PMC3660106
View in: PubMed

14.Carpenter MJ, Hughes JR, Gray KM, Wahlquist AE, Saladin ME, Alberg AJ. Nicotine therapy sampling to induce quit attempts among smokers unmotivated to quit: a randomized clinical trial. Arch Intern Med. .171(21):1901-7, 2011. PMCID: PMC3372898
View in: PubMed

15.Gray KM, Carpenter MJ, Lewis AL, Klintworth EM, Upadhyaya HP. Varenicline versus bupropion XL for smoking cessation in older adolescents: a randomized, double-blind pilot trial. Nicotine Tob Res. .14(2):234-9, 2011. PMCID: PMC3265741
View in: PubMed

16.Brady KT, Gray KM, Tolliver BK. Cognitive enhancers in the treatment of substance use disorders: clinical evidence. Pharmacol Biochem Behav. .99(2):285-94, 2011. PMCID: PMC3114106
View in: PubMed

17.Gray KM, Riggs PD, Min SJ, Mikulich-Gilbertson SK, Bandyopadhyay D, Winhusen T. Cigarette and cannabis use trajectories among adolescents in treatment for attention-deficit/hyperactivity disorder and substance use disorders. Drug Alcohol Depend. .117(2-3):242-7, 2011. PMCID: PMC3128687
View in: PubMed

18.Gray KM, Carpenter MJ, Baker NL, Hartwell KJ, Lewis AL, Hiott DW, Deas D, Upadhyaya HP. Bupropion SR and contingency management for adolescent smoking cessation. J Subst Abuse Treat. .40(1):77-86, 2010. PMCID: PMC2997899
View in: PubMed

19.Gray KM, LaRowe SD, Watson NL, Carpenter MJ. Reactivity to in vivo marijuana cues among cannabis-dependent adolescents. Addict Behav. .36(1-2):140-3, 2010. PMCID: PMC2981614
View in: PubMed

20.Gray KM, Baker NL, Carpenter MJ, Lewis AL, Upadhyaya HP. Attention-deficit/hyperactivity disorder confounds nicotine withdrawal self-report in adolescent smokers. Am J Addict. .19(4):325-31, 2010. PMCID: PMC2911152
View in: PubMed

21.Carpenter MJ, Baker NL, Gray KM, Upadhyaya HP. Assessment of nicotine dependence among adolescent and young adult smokers: a comparison of measures. Addict Behav. .35(11):977-82, 2010. PMCID: PMC2919624
View in: PubMed

22.Carpenter MJ, Alberg AJ, Gray KM, Saladin ME. Motivating the unmotivated for health behavior change: a randomized trial of cessation induction for smokers. Clin Trials. .7(2):157-66, 2010. PMCID: PMC2902976
View in: PubMed

23.Gray KM, Watson NL, Carpenter MJ, Larowe SD. N-acetylcysteine (NAC) in young marijuana users: an open-label pilot study. Am J Addict. .19(2):187-9, 2010. PMCID: PMC2826714
View in: PubMed

24.Watson NL, Carpenter MJ, Saladin ME, Gray KM, Upadhyaya HP. Evidence for greater cue reactivity among low-dependent vs. high-dependent smokers. Addict Behav. .35(7):673-7, 2010. PMCID: PMC2856788
View in: PubMed

25.Carpenter MJ, Gray KM. A pilot randomized study of smokeless tobacco use among smokers not interested in quitting: changes in smoking behavior and readiness to quit. Nicotine Tob Res. .12(2):136-43, 2010. PMCID: PMC2816197
View in: PubMed

26.Gray KM, DeSantis SM, Carpenter MJ, Saladin ME, LaRowe SD, Upadhyaya HP. Menstrual cycle and cue reactivity in women smokers. Nicotine Tob Res. .12(2):174-8, 2009. PMCID: PMC2816193
View in: PubMed

27.Gray KM, Upadhyaya HP. Tobacco smoking in individuals with attention-deficit hyperactivity disorder: epidemiology and pharmacological approaches to cessation. CNS Drugs. .23(8):661-8, 2009. PMCID: PMC2782603
View in: PubMed

28.Carpenter MJ, Saladin ME, DeSantis S, Gray KM, LaRowe SD, Upadhyaya HP. Laboratory-based, cue-elicited craving and cue reactivity as predictors of naturally occurring smoking behavior. Addict Behav. .34(6-7):536-41, 2009. PMCID: PMC2685198
View in: PubMed

29.Gray KM, Watson NL, Christie DK. Challenges in quantifying marijuana use. Am J Addict. .18(2):178-9, 2009. PMCID: PMC2688383
View in: PubMed

30.Gray KM, LaRowe SD, Upadhyaya HP. Cue reactivity in young marijuana smokers: a preliminary investigation. Psychol Addict Behav. .22(4):582-6, 2008. PMCID: PMC2605672
View in: PubMed

31.Gray KM, Hart CL, Christie DK, Upadhyaya HP. Tolerability and effects of oral Delta9-tetrahydrocannabinol in older adolescents with marijuana use disorders. Pharmacol Biochem Behav. .91(1):67-70, 2008. PMCID: PMC2567109
View in: PubMed

32.Gray KM, Upadhyaya HP, Deas D, Brady KT. Advances in diagnosis of adolescent substance abuse. Adolesc Med Clin. .17(2):411-25, 2006.
View in: PubMed

33.Gray KM, Schuyler D. Conquering an Unmasked Social Phobia. Prim Care Companion J Clin Psychiatry. .5(3):137-138, 2003. PMCID: PMC406381
View in: PubMed

34.Beischel CJ, Gray K, Hazard ES, Knapp DR, Crouch RK. Evaluation of photoaffinity labeled sites of bacteriorhodopsin using molecular modeling. Biochem Mol Biol Int. .32(5):933-9, 1994.
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