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Kevin M Gray, MD
Professor of Psychiatry & Behavioral Sciences
College of Medicine
MUSC

Email: graykm@musc.edu
 
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Kevin M Gray, MD

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Research Interest:

Dr. Gray conducts investigations focusing on nicotine dependence. He recently completed a large-scale randomized trial of bupropion and contingency management in nicotine-dependent adolescents, and is now conducting a trial of varenicline and bupropion XL in adolescent smokers.

Selected Publications:

1.Squeglia LM, Gray KM. Alcohol and Drug Use and the Developing Brain. Curr Psychiatry Rep. .18(5):46, 2016. PMID: 26984684
View in: PubMed

2.Allen AM, McRae-Clark AL, Carlson S, Saladin ME, Gray KM, Wetherington CL, McKee SA, Allen SS. Determining menstrual phase in human biobehavioral research: A review with recommendations. Exp Clin Psychopharmacol. .24(1):1-11, 2016. PMID: 26570992 PMCID: PMC4821777
View in: PubMed

3.Bentzley JP, Tomko RL, Gray KM. Low Pretreatment Impulsivity and High Medication Adherence Increase the Odds of Abstinence in a Trial of N-Acetylcysteine in Adolescents with Cannabis Use Disorder. J Subst Abuse Treat. .63:72-7, 2015. PMID: 26827257 PMCID: PMC4775311
View in: PubMed

4.McRae-Clark AL, Baker NL, Gray KM, Killeen T, Hartwell KJ, Simonian SJ. Vilazodone for cannabis dependence: A randomized, controlled pilot trial. Am J Addict. .25(1):69-75, 2015. PMID: 26685701
View in: PubMed

5.McRae-Clark AL, Baker NL, Gray KM, Killeen TK, Wagner AM, Brady KT, DeVane CL, Norton J. Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial. Drug Alcohol Depend. .156:29-37, 2015. PMID: 26386827 PMCID: PMC4633378
View in: PubMed

6.Saladin ME, McClure EA, Baker NL, Carpenter MJ, Ramakrishnan V, Hartwell KJ, Gray KM. Increasing progesterone levels are associated with smoking abstinence among free-cycling women smokers who receive brief pharmacotherapy. Nicotine Tob Res. .17(4):398-406, 2015. PMID: 25762749 PMCID: PMC4432400
View in: PubMed

7.Weinberger AH, Smith PH, Allen SS, Cosgrove KP, Saladin ME, Gray KM, Mazure CM, Wetherington CL, McKee SA. Systematic and meta-analytic review of research examining the impact of menstrual cycle phase and ovarian hormones on smoking and cessation. Nicotine Tob Res. .17(4):407-21, 2015. PMID: 25762750 PMCID: PMC4429881
View in: PubMed

8.Wray JM, Gray KM, McClure EA, Carpenter MJ, Tiffany ST, Saladin ME. Gender differences in responses to cues presented in the natural environment of cigarette smokers. Nicotine Tob Res. .17(4):438-42, 2015. PMID: 25762753 PMCID: PMC4432398
View in: PubMed

9.Gray KM, McClure EA, Baker NL, Hartwell KJ, Carpenter MJ, Saladin ME. An exploratory short-term double-blind randomized trial of varenicline versus nicotine patch for smoking cessation in women. Addiction. .110(6):1027-34, 2015. PMID: 25727442 PMCID: PMC4430389
View in: PubMed

10.Roten A, Baker NL, Gray KM. Cognitive performance in a placebo-controlled pharmacotherapy trial for youth with marijuana dependence. Addict Behav. .45:119-23, 2015. PMID: 25661990 PMCID: PMC4373963
View in: PubMed

11.McClure EA, Lydiard JB, Goddard SD, Gray KM. Objective and subjective memory ratings in cannabis-dependent adolescents. Am J Addict. .24(1):47-52, 2015. PMID: 25823635 PMCID: PMC4389632
View in: PubMed

12.Saladin ME, Wray JM, Carpenter MJ, McClure EA, LaRowe SD, Upadhyaya HP, Gray KM. Menstrual cycle phase effects in the gender dimorphic stress cue reactivity of smokers. Nicotine Tob Res. .17(5):607-11, 2014. PMID: 25324432 PMCID: PMC4402356
View in: PubMed

13.McClure EA, Sonne SC, Winhusen T, Carroll KM, Ghitza UE, McRae-Clark AL, Matthews AG, Sharma G, Van Veldhuisen P, Vandrey RG, Levin FR, Weiss RD, Lindblad R, Allen C, Mooney LJ, Haynes L, Brigham GS, Sparenborg S, Hasson AL, Gray KM. Achieving cannabis cessation -- evaluating N-acetylcysteine treatment (ACCENT): design and implementation of a multi-site, randomized controlled study in the National Institute on Drug Abuse Clinical Trials Network. Contemp Clin Trials. .39(2):211-23, 2014. PMID: 25179587 PMCID: PMC4252394
View in: PubMed

14.McClure EA, Baker NL, Gipson CD, Carpenter MJ, Roper AP, Froeliger BE, Kalivas PW, Gray KM. An open-label pilot trial of N-acetylcysteine and varenicline in adult cigarette smokers. Am J Drug Alcohol Abuse. .41(1):52-6, 2014. PMID: 25062287 PMCID: PMC4262740
View in: PubMed

15.Adisetiyo V, Jensen JH, Tabesh A, Deardorff RL, Fieremans E, Di Martino A, Gray KM, Castellanos FX, Helpern JA. Multimodal MR imaging of brain iron in attention deficit hyperactivity disorder: a noninvasive biomarker that responds to psychostimulant treatment? Radiology. .272(2):524-32, 2014. PMID: 24937545 PMCID: PMC4263268
View in: PubMed

16.Mathew AR, Wahlquist AE, Garrett-Mayer E, Gray KM, Saladin ME, Carpenter MJ. Affective motives for smoking among early stage smokers. Nicotine Tob Res. .16(10):1387-93, 2014. PMID: 24924155 PMCID: PMC4207875
View in: PubMed

17.McClure EA, Baker NL, Gray KM. Cigarette smoking during an N-acetylcysteine-assisted cannabis cessation trial in adolescents. Am J Drug Alcohol Abuse. .40(4):285-91, 2014. PMID: 24720376 PMCID: PMC4118750
View in: PubMed

18.Jardin BF, Cropsey KL, Wahlquist AE, Gray KM, Silvestri GA, Cummings KM, Carpenter MJ. Evaluating the effect of access to free medication to quit smoking: a clinical trial testing the role of motivation. Nicotine Tob Res. .16(7):992-9, 2014. PMID: 24610399 PMCID: PMC4133568
View in: PubMed

19.McClure EA, Gipson CD, Malcolm RJ, Kalivas PW, Gray KM. Potential role of N-acetylcysteine in the management of substance use disorders. CNS Drugs. .28(2):95-106, 2014. PMID: 24442756 PMCID: PMC4009342
View in: PubMed

20.Milsom VA, Malcolm RJ, Johnson GC, Pechon SM, Gray KM, Miller-Kovach K, Rost SL, O'Neil PM. Changes in cardiovascular risk factors with participation in a 12-week weight loss trial using a commercial format. Eat Behav. .15(1):68-71, 2013. PMID: 24411753
View in: PubMed

21.Burris JL, Carpenter MJ, Wahlquist AE, Cummings KM, Gray KM. Brief, instructional smokeless tobacco use among cigarette smokers who do not intend to quit: a pilot randomized clinical trial. Nicotine Tob Res. .16(4):397-405, 2013. PMID: 24130144 PMCID: PMC3954419
View in: PubMed

22.Carpenter MJ, Saladin ME, Larowe SD, McClure EA, Simonian S, Upadhyaya HP, Gray KM. Craving, cue reactivity, and stimulus control among early-stage young smokers: effects of smoking intensity and gender. Nicotine Tob Res. .16(2):208-15, 2013. PMID: 24042699 PMCID: PMC3880235
View in: PubMed

23.McClure EA, Saladin ME, Baker NL, Carpenter MJ, Gray KM. Smoking topography and abstinence in adult female smokers. Addict Behav. .38(12):2833-6, 2013. PMID: 24018226 PMCID: PMC3805754
View in: PubMed

24.Thrasher JF, Andrews JO, Friedman DB, Carpenter MJ, Gray KM, Cummings KM, Alberg AJ, Navarro A. Author response. Am J Prev Med. .44(5):e51-3, 2013. PMID: 23597825
View in: PubMed

25.Lewis AL, Baker N, Carpenter M, Klintworth E, Gray KM. Does physician continuity within a clinical trial increase retention and compliance among adolescent smokers? Adolesc Psychiatry (Hilversum). .3(2), 2013. PMID: 24349962 PMCID: PMC3857140
View in: PubMed

26.McClure EA, Gray KM. The Remote Monitoring of Smoking in Adolescents. Adolesc Psychiatry (Hilversum). .3(2):156-162, 2013. PMID: 24834379 PMCID: PMC4019076
View in: PubMed

27.Saladin ME, Gray KM, McRae-Clark AL, Larowe SD, Yeatts SD, Baker NL, Hartwell KJ, Brady KT. A double blind, placebo-controlled study of the effects of post-retrieval propranolol on reconsolidation of memory for craving and cue reactivity in cocaine dependent humans. Psychopharmacology (Berl). .226(4):721-37, 2013. PMID: 23460266 PMCID: PMC3637960
View in: PubMed

28.Hartwell KJ, Lematty T, McRae-Clark AL, Gray KM, George MS, Brady KT. Resisting the urge to smoke and craving during a smoking quit attempt on varenicline: results from a pilot fMRI study. Am J Drug Alcohol Abuse. .39(2):92-8, 2013. PMID: 23421569 PMCID: PMC4501024
View in: PubMed

29.Thrasher JF, Carpenter MJ, Andrews JO, Gray KM, Alberg AJ, Navarro A, Friedman DB, Cummings KM. Cigarette warning label policy alternatives and smoking-related health disparities. Am J Prev Med. .43(6):590-600, 2012. PMID: 23159254 PMCID: PMC3504356
View in: PubMed

30.Roten AT, Baker NL, Gray KM. Marijuana craving trajectories in an adolescent marijuana cessation pharmacotherapy trial. Addict Behav. .38(3):1788-91, 2012. PMID: 23261493 PMCID: PMC3558535
View in: PubMed

31.Gray KM, Carpenter MJ, Baker NL, DeSantis SM, Kryway E, Hartwell KJ, McRae-Clark AL, Brady KT. A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. Am J Psychiatry. .169(8):805-12, 2012. PMID: 22706327 PMCID: PMC3410961
View in: PubMed

32.Saladin ME, Gray KM, Carpenter MJ, LaRowe SD, DeSantis SM, Upadhyaya HP. Gender differences in craving and cue reactivity to smoking and negative affect/stress cues. Am J Addict. .21(3):210-20, 2012. PMID: 22494223 PMCID: PMC3325498
View in: PubMed

33.Schiller CE, Saladin ME, Gray KM, Hartwell KJ, Carpenter MJ. Association between ovarian hormones and smoking behavior in women. Exp Clin Psychopharmacol. .20(4):251-7, 2012. PMID: 22545725 PMCID: PMC3660106
View in: PubMed

34.Carpenter MJ, Hughes JR, Gray KM, Wahlquist AE, Saladin ME, Alberg AJ. Nicotine therapy sampling to induce quit attempts among smokers unmotivated to quit: a randomized clinical trial. Arch Intern Med. .171(21):1901-7, 2011. PMID: 22123796 PMCID: PMC3372898
View in: PubMed

35.Gray KM, Carpenter MJ, Lewis AL, Klintworth EM, Upadhyaya HP. Varenicline versus bupropion XL for smoking cessation in older adolescents: a randomized, double-blind pilot trial. Nicotine Tob Res. .14(2):234-9, 2011. PMID: 21778151 PMCID: PMC3265741
View in: PubMed

36.Brady KT, Gray KM, Tolliver BK. Cognitive enhancers in the treatment of substance use disorders: clinical evidence. Pharmacol Biochem Behav. .99(2):285-94, 2011. PMID: 21557964 PMCID: PMC3114106
View in: PubMed

37.Gray KM, Riggs PD, Min SJ, Mikulich-Gilbertson SK, Bandyopadhyay D, Winhusen T. Cigarette and cannabis use trajectories among adolescents in treatment for attention-deficit/hyperactivity disorder and substance use disorders. Drug Alcohol Depend. .117(2-3):242-7, 2011. PMID: 21411243 PMCID: PMC3128687
View in: PubMed

38.Gray KM, Carpenter MJ, Baker NL, Hartwell KJ, Lewis AL, Hiott DW, Deas D, Upadhyaya HP. Bupropion SR and contingency management for adolescent smoking cessation. J Subst Abuse Treat. .40(1):77-86, 2010. PMID: 20934835 PMCID: PMC2997899
View in: PubMed

39.Gray KM, LaRowe SD, Watson NL, Carpenter MJ. Reactivity to in vivo marijuana cues among cannabis-dependent adolescents. Addict Behav. .36(1-2):140-3, 2010. PMID: 20851531 PMCID: PMC2981614
View in: PubMed

40.Gray KM, Baker NL, Carpenter MJ, Lewis AL, Upadhyaya HP. Attention-deficit/hyperactivity disorder confounds nicotine withdrawal self-report in adolescent smokers. Am J Addict. .19(4):325-31, 2010. PMID: 20653639 PMCID: PMC2911152
View in: PubMed

41.Carpenter MJ, Baker NL, Gray KM, Upadhyaya HP. Assessment of nicotine dependence among adolescent and young adult smokers: a comparison of measures. Addict Behav. .35(11):977-82, 2010. PMID: 20624670 PMCID: PMC2919624
View in: PubMed

42.Carpenter MJ, Alberg AJ, Gray KM, Saladin ME. Motivating the unmotivated for health behavior change: a randomized trial of cessation induction for smokers. Clin Trials. .7(2):157-66, 2010. PMID: 20338901 PMCID: PMC2902976
View in: PubMed

43.Gray KM, Watson NL, Carpenter MJ, Larowe SD. N-acetylcysteine (NAC) in young marijuana users: an open-label pilot study. Am J Addict. .19(2):187-9, 2010. PMID: 20163391 PMCID: PMC2826714
View in: PubMed

44.Watson NL, Carpenter MJ, Saladin ME, Gray KM, Upadhyaya HP. Evidence for greater cue reactivity among low-dependent vs. high-dependent smokers. Addict Behav. .35(7):673-7, 2010. PMID: 20206451 PMCID: PMC2856788
View in: PubMed

45.Carpenter MJ, Gray KM. A pilot randomized study of smokeless tobacco use among smokers not interested in quitting: changes in smoking behavior and readiness to quit. Nicotine Tob Res. .12(2):136-43, 2010. PMID: 20053788 PMCID: PMC2816197
View in: PubMed

46.Gray KM, DeSantis SM, Carpenter MJ, Saladin ME, LaRowe SD, Upadhyaya HP. Menstrual cycle and cue reactivity in women smokers. Nicotine Tob Res. .12(2):174-8, 2009. PMID: 19996146 PMCID: PMC2816193
View in: PubMed

47.Gray KM, Upadhyaya HP. Tobacco smoking in individuals with attention-deficit hyperactivity disorder: epidemiology and pharmacological approaches to cessation. CNS Drugs. .23(8):661-8, 2009. PMID: 19594195 PMCID: PMC2782603
View in: PubMed

48.Carpenter MJ, Saladin ME, DeSantis S, Gray KM, LaRowe SD, Upadhyaya HP. Laboratory-based, cue-elicited craving and cue reactivity as predictors of naturally occurring smoking behavior. Addict Behav. .34(6-7):536-41, 2009. PMID: 19395178 PMCID: PMC2685198
View in: PubMed

49.Gray KM, Watson NL, Christie DK. Challenges in quantifying marijuana use. Am J Addict. .18(2):178-9, 2009. PMID: 19283572 PMCID: PMC2688383
View in: PubMed

50.Gray KM, LaRowe SD, Upadhyaya HP. Cue reactivity in young marijuana smokers: a preliminary investigation. Psychol Addict Behav. .22(4):582-6, 2008. PMID: 19071985 PMCID: PMC2605672
View in: PubMed

51.Gray KM, Hart CL, Christie DK, Upadhyaya HP. Tolerability and effects of oral Delta9-tetrahydrocannabinol in older adolescents with marijuana use disorders. Pharmacol Biochem Behav. .91(1):67-70, 2008. PMID: 18627775 PMCID: PMC2567109
View in: PubMed

52.Gray KM, Upadhyaya HP, Deas D, Brady KT. Advances in diagnosis of adolescent substance abuse. Adolesc Med Clin. .17(2):411-25, 2006. PMID: 16814700
View in: PubMed

53.Gray KM, Schuyler D. Conquering an Unmasked Social Phobia. Prim Care Companion J Clin Psychiatry. .5(3):137-138, 2003. PMID: 15154025 PMCID: PMC406381
View in: PubMed

54.Beischel CJ, Gray K, Hazard ES, Knapp DR, Crouch RK. Evaluation of photoaffinity labeled sites of bacteriorhodopsin using molecular modeling. Biochem Mol Biol Int. .32(5):933-9, 1994. PMID: 8069243
View in: PubMed