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Bo Cen, PhD
Assistant Professor of Medicine
College of Medicine
MUSC

Email: cen@musc.edu
 
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Bo Cen, PhD

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Research Interest:

My research interests include prostate cancer development mechanisms, prostate cancer biomarker identification, and prostate stem cells. I have significant experience studying signal transduction and regulation of transcription factors in both solid and liquid tumor systems. Since joining the Medical University of South Carolina as an Assistant Professor, I have been focused on the Pim protein kinase. I am currently the Principal Investigator on an NIH/NIDDK funded career development award entitled, "Role of Pim Kinases in Prostate Epithelium Growth".

Selected Publications:

1.Cen B, Xiong Y, Song JH, Mahajan S, DuPont R, McEachern K, DeAngelo DJ, Cortes JE, Minden MD, Ebens A, Mims A, LaRue AC, Kraft AS. The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol. .34(13):2517-32, 2014. PMCID: PMC4054323
View in: PubMed

2.Cen B, Mahajan S, Wang W, Kraft AS. Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1. Cancer Res. .73(11):3402-11, 2013. PMCID: PMC3680595
View in: PubMed

3.Cen B, Mahajan S, Zemskova M, Beharry Z, Lin YW, Cramer SD, Lilly MB, Kraft AS. Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem. .285(38):29128-37, 2010. PMCID: PMC2937943
View in: PubMed

4.Cen B, Li H, Weinstein IB. Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. J Biol Chem. .284(8):5265-76, 2008.
View in: PubMed

5.Li H, Balajee AS, Su T, Cen B, Hei TK, Weinstein IB. The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage. J Cell Biol. .183(2):253-65, 2008. PMCID: PMC2568022
View in: PubMed

6.Cen B, Deguchi A, Weinstein IB. Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1. Cancer Res. .68(13):5355-62, 2008.
View in: PubMed

7.Cen B, Selvaraj A, Prywes R. Myocardin/MKL family of SRF coactivators: key regulators of immediate early and muscle specific gene expression. J Cell Biochem. .93(1):74-82, 2004.
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8.Cen B, Selvaraj A, Burgess RC, Hitzler JK, Ma Z, Morris SW, Prywes R. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol Cell Biol. .23(18):6597-608, 2003. PMCID: PMC193697
View in: PubMed

9.Cen B, Xiong Y, Ma L, Pei G. Direct and differential interaction of beta-arrestins with the intracellular domains of different opioid receptors. Mol Pharmacol. .59(4):758-64, 2001.
View in: PubMed

10.Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, Ma L, Pei G. Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor. J Neurochem. .76(6):1887-94, 2001.
View in: PubMed

11.Cheng ZJ, Zhao J, Sun Y, Hu W, Wu YL, Cen B, Wu GX, Pei G. beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J Biol Chem. .275(4):2479-85, 2000.
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12.Yu QM, Cheng ZJ, Zhou TH, Cen B, Guo SQ, Pei G. Molecular Cloning of Human beta-arrestin1 cDNA, Expression and Functional Study. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). .31(3):344-346, 1999.
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13.Cen B, Jin W, Wu H, Lu J, Dong X, Xu X. Glycine68 to histidine73 has an important role in the function of human tumor necrosis factor alpha. Biochem Mol Biol Int. .43(1):47-52, 1997.
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14.Jiang X, Zhou A, Cen B, Qiu Q, Dong X, Xu X. Expression of soluble, active human macrophage colony stimulating factor in Escherichia coli. Biochem Mol Biol Int. .42(2):325-8, 1997.
View in: PubMed