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Melanie B Thomas, MD
Associate Professor of Medicine
Hematology/Oncology
College of Medicine
MUSC

Email: thomasmb@musc.edu
 
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Melanie B Thomas, MD

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Research Interest:

I am a medical oncologist with a clinical practice and research interests focusing on gastrointestinal malignancies, specifically pancreatic, hepatobiliary and colorectal cancers. I have been the Principal Investigator on numerous clinical trials of novel biologic anti-cancer agents in GI malignancies. The spectrum of clinical trials I have led or been a clinical collaborator on includes investigator-initiated, SWOG, industry sponsored, and CTEP-sponsored Phase I, II and randomized Phase II trials. As the Associate Director of Clinical Investigations at the Medical University of South Carolina Hollings Cancer Center, I wholeheartedly support the endeavors of my colleagues in the Cancer Center.

Honors:
Grace E. DeWolff Endowed Chair in Medical Oncology, SmartState Center of Economic Excellence

Positions:
Associate Director of Clinical Investigations, Hollings Cancer Center, Medical University of South Carolina

Selected Publications:

1.Javle M, Churi C, Kang HC, Shroff R, Janku F, Surapaneni R, Zuo M, Barrera C, Alshamsi H, Krishnan S, Mishra L, Wolff RA, Kaseb AO, Thomas MB, Siegel AB. HER2/neu-directed therapy for biliary tract cancer. J Hematol Oncol. .8:58, 2015. PMID: 26022204 PMCID: PMC4469402
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2.Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD. SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma. J Clin Oncol. .33(24):2617-22, 2015. PMID: 25964250 PMCID: PMC4534524
View in: PubMed

3.Esnaola NF, Chaudhary UB, O'Brien P, Garrett-Mayer E, Camp ER, Thomas MB, Cole DJ, Montero AJ, Hoffman BJ, Romagnuolo J, Orwat KP, Marshall DT. Phase 2 trial of induction gemcitabine, oxaliplatin, and cetuximab followed by selective capecitabine-based chemoradiation in patients with borderline resectable or unresectable locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys. .88(4):837-44, 2014. PMID: 24606850 PMCID: PMC4120643
View in: PubMed

4.Thomas MB. Systemic and targeted therapy for biliary tract tumors and primary liver tumors. Surg Oncol Clin N Am. .23(2):369-81, 2013. PMID: 24560115
View in: PubMed

5.Wallace K, Sterba KR, Gore E, Lewin DN, Ford ME, Thomas MB, Alberg AJ. Prognostic factors in relation to racial disparity in advanced colorectal cancer survival. Clin Colorectal Cancer. .12(4):287-93, 2013. PMID: 24188687 PMCID: PMC3863997
View in: PubMed

6.Maithel SK, Gamblin TC, Kamel I, Corona-Villalobos CP, Thomas M, Pawlik TM. Multidisciplinary approaches to intrahepatic cholangiocarcinoma. Cancer. .119(22):3929-42, 2013. PMID: 23963845
View in: PubMed

7.Wallace K, Hill EG, Lewin DN, Williamson G, Oppenheimer S, Ford ME, Wargovich MJ, Berger FG, Bolick SW, Thomas MB, Alberg AJ. Racial disparities in advanced-stage colorectal cancer survival. Cancer Causes Control. .24(3):463-71, 2013. PMID: 23296454 PMCID: PMC3574218
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8.Sterba KR, Zapka J, Gore EI, Ford ME, Ford DW, Thomas M, Wallace K. Exploring dimensions of coping in advanced colorectal cancer: implications for patient-centered care. J Psychosoc Oncol. .31(5):517-39, 2013. PMID: 24010530
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9.Yang Y, Mauldin PD, Ebeling M, Hulsey TC, Liu B, Thomas MB, Camp ER, Esnaola NF. Effect of metabolic syndrome and its components on recurrence and survival in colon cancer patients. Cancer. .119(8):1512-20, 2012. PMID: 23280333
View in: PubMed

10.Friday B, Lassere Y, Meyers CA, Mita A, Abbruzzese JL, Thomas MB. A phase I study to determine the safety and pharmacokinetics of intravenous administration of TAS-106 once per week for three consecutive weeks every 28 days in patients with solid tumors. Anticancer Res. .32(5):1689-96, 2012. PMID: 22593447
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11.Kaseb AO, Garrett-Mayer E, Morris JS, Xiao L, Lin E, Onicescu G, Hassan MM, Hassabo HM, Iwasaki M, Deaton FL, Abbruzzese JL, Thomas MB. Efficacy of bevacizumab plus erlotinib for advanced hepatocellular carcinoma and predictors of outcome: final results of a phase II trial. Oncology. .82(2):67-74, 2012. PMID: 22327795
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12.Park JW, Finn RS, Kim JS, Karwal M, Li RK, Ismail F, Thomas M, Harris R, Baudelet C, Walters I, Raoul JL. Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin Cancer Res. .17(7):1973-83, 2011. PMID: 21349999
View in: PubMed

13.Hammond-Thelin LA, Thomas MB, Iwasaki M, Abbruzzese JL, Lassere Y, Meyers CA, Hoff P, de Bono J, Norris J, Matsushita H, Mita A, Rowinsky EK. Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies. Invest New Drugs. .30(1):316-26, 2010. PMID: 20839029
View in: PubMed

14.Thomas MB, Jaffe D, Choti MM, Belghiti J, Curley S, Fong Y, Gores G, Kerlan R, Merle P, O'Neil B, Poon R, Schwartz L, Tepper J, Yao F, Haller D, Mooney M, Venook A. Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting. J Clin Oncol. .28(25):3994-4005, 2010. PMID: 20679622 PMCID: PMC2940397
View in: PubMed

15.Burak KW, Thomas MB, Zhu AX. Nonoperative therapies for combined modality treatment of hepatocellular cancer: expert consensus conference. HPB (Oxford). .12(5):321-2, 2010. PMID: 20590906 PMCID: PMC2951819
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16.Hassan MM, Kaseb A, Li D, Patt YZ, Vauthey JN, Thomas MB, Curley SA, Spitz MR, Sherman SI, Abdalla EK, Davila M, Lozano RD, Hassan DM, Chan W, Brown TD, Abbruzzese JL. Association between hypothyroidism and hepatocellular carcinoma: a case-control study in the United States. Hepatology. .49(5):1563-70, 2009. PMID: 19399911 PMCID: PMC3715879
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17.Thomas MB. CanLiv: Shining a Light on Cancer's Neglected "Orphans". Gastrointest Cancer Res. .3(3):131-2, 2009. PMID: 19626159 PMCID: PMC2713140
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18.Thomas MB. Toward improved outcomes in hepatocellular carcinoma: overcoming the challenges of an "orphan" tumor. Gastrointest Cancer Res. .3(2):73, 2009. PMID: 19461909 PMCID: PMC2684725
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19.Thomas M. Molecular targeted therapy for hepatocellular carcinoma. J Gastroenterol. .44 Suppl 19:136-41, 2009. PMID: 19148808
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20.Thomas MB, Morris JS, Chadha R, Iwasaki M, Kaur H, Lin E, Lin E, Kaseb A, Glover K, Davila M, Abbruzzese J. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol. .27(6):843-50, 2009. PMID: 19139433
View in: PubMed

21.García P, Manterola C, Araya JC, Villaseca M, Guzmán P, Sanhueza A, Thomas M, Alvarez H, Roa JC. Promoter methylation profile in preneoplastic and neoplastic gallbladder lesions. Mol Carcinog. .48(1):79-89, 2009. PMID: 18543280
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22.Hassan MM, Spitz MR, Thomas MB, Curley SA, Patt YZ, Vauthey JN, Glover KY, Kaseb A, Lozano RD, El-Deeb AS, Nguyen NT, Wei SH, Chan W, Abbruzzese JL, Li D. The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States. J Hepatol. .50(2):334-41, 2008. PMID: 19070394 PMCID: PMC2658718
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23.Hassan MM, Spitz MR, Thomas MB, El-Deeb AS, Glover KY, Nguyen NT, Chan W, Kaseb A, Curley SA, Vauthey JN, Ellis LM, Abdalla E, Lozano RD, Patt YZ, Brown TD, Abbruzzese JL, Li D. Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study. Int J Cancer. .123(8):1883-91, 2008. PMID: 18688864 PMCID: PMC2673571
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24.Borghero Y, Crane CH, Szklaruk J, Oyarzo M, Curley S, Pisters PW, Evans D, Abdalla EK, Thomas MB, Das P, Wistuba II, Krishnan S, Vauthey JN. Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone. Ann Surg Oncol. .15(11):3147-56, 2008. PMID: 18754070
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25.Overman MJ, Varadhachary G, Kopetz S, Thomas MB, Fukushima M, Kuwata K, Mita A, Wolff RA, Hoff PM, Xiong H, Abbruzzese JL. Phase 1 study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors. Invest New Drugs. .26(5):445-54, 2008. PMID: 18528634
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26.Higginbotham KB, Lozano R, Brown T, Patt YZ, Arima T, Abbruzzese JL, Thomas MB. A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma. J Cancer Res Clin Oncol. .134(12):1325-35, 2008. PMID: 18504614
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27.Thomas MB. Targeted therapies for cancer of the gallbladder. Curr Opin Gastroenterol. .24(3):372-6, 2008. PMID: 18408467
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28.Miyahara N, Shoda J, Ishige K, Kawamoto T, Ueda T, Taki R, Ohkohchi N, Hyodo I, Thomas MB, Krishnamurthy S, Carraway KL, Irimura T. MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications. Eur J Cancer. .44(7):1048-56, 2008. PMID: 18397823
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29.Thomas MB, Wright JD, Leiser AL, Chi DS, Mutch DG, Podratz KC, Dowdy SC. Clear cell carcinoma of the cervix: a multi-institutional review in the post-DES era. Gynecol Oncol. .109(3):335-9, 2008. PMID: 18394687 PMCID: PMC3667392
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30.Thomas MB, Lawrence TS. From the guest editors. Hepatocellular carcinoma. Cancer J. .14(2):94, 2008. PMID: 18391613
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31.Thomas MB. Systemic therapy for hepatocellular carcinoma. Cancer J. .14(2):123-7, 2008. PMID: 18391618
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32.Thomas MB, O'Beirne JP, Furuse J, Chan AT, Abou-Alfa G, Johnson P. Systemic therapy for hepatocellular carcinoma: cytotoxic chemotherapy, targeted therapy and immunotherapy. Ann Surg Oncol. .15(4):1008-14, 2008. PMID: 18236117
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33.Thomas MB, Davila M, Abbruzzese JL. Stemming the tide of hepatitis B virus related hepatocellular carcinoma? J Clin Oncol. .26(2):172-4, 2008. PMID: 18182657
View in: PubMed

34.Thomas MB, Tetzlaff E, Lozano R, Samp L, Butler CE, Gannon C, Hamilton S, Vauthey JN, Abdalla E. Curing hepatocellular carcinomatosis with biologic therapy and surgery: achieving the impossible? J Surg Oncol. .97(1):82-4, 2008. PMID: 17918216
View in: PubMed

35.Ribero D, Wang H, Donadon M, Zorzi D, Thomas MB, Eng C, Chang DZ, Curley SA, Abdalla EK, Ellis LM, Vauthey JN. Bevacizumab improves pathologic response and protects against hepatic injury in patients treated with oxaliplatin-based chemotherapy for colorectal liver metastases. Cancer. .110(12):2761-7, 2007. PMID: 17960603
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36.Kawamoto T, Krishnamurthy S, Tarco E, Trivedi S, Wistuba II, Li D, Roa I, Roa JC, Thomas MB. HER Receptor Family: Novel Candidate for Targeted Therapy for Gallbladder and Extrahepatic Bile Duct Cancer. Gastrointest Cancer Res. .1(6):221-7, 2007. PMID: 19262900 PMCID: PMC2631213
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37.Thomas MB, Mariani A, Cliby WA, Keeney GL, Podratz KC, Dowdy SC. Role of cytoreduction in stage III and IV uterine papillary serous carcinoma. Gynecol Oncol. .107(2):190-3, 2007. PMID: 17825394
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38.Thomas MB, Chadha R, Glover K, Wang X, Morris J, Brown T, Rashid A, Dancey J, Abbruzzese JL. Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer. .110(5):1059-67, 2007. PMID: 17623837
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39.Thomas MB, Mariani A, Cliby WA, Keeney GA, Podratz KC, Dowdy SC. Role of systematic lymphadenectomy and adjuvant therapy in stage I uterine papillary serous carcinoma. Gynecol Oncol. .107(2):186-9, 2007. PMID: 17688926
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40.Wu Q, Kiguchi K, Kawamoto T, Ajiki T, Traag J, Carbajal S, Ruffino L, Thames H, Wistuba I, Thomas M, Vasquez KM, DiGiovanni J. Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model. Cancer Res. .67(8):3794-800, 2007. PMID: 17440093
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41.Thomas MB. Biological characteristics of cancers in the gallbladder and biliary tract and targeted therapy. Crit Rev Oncol Hematol. .61(1):44-51, 2007. PMID: 17164111
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42.Ribero D, Abdalla EK, Thomas MB, Vauthey JN. Liver resection in the treatment of hepatocellular carcinoma. Expert Rev Anticancer Ther. .6(4):567-79, 2006. PMID: 16613544
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43.Thomas MB, Abbruzzese JL. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol. .23(31):8093-108, 2005. PMID: 16258107
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44.Thomas MB, Zhu AX. Hepatocellular carcinoma: the need for progress. J Clin Oncol. .23(13):2892-9, 2005. PMID: 15860847
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45.Pawlik TM, Scoggins CR, Thomas MB, Vauthey JN. Advances in the surgical management of liver malignancies. Cancer J. .10(2):74-87, 2004. PMID: 15130267
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46.Shaughnessy L, Chamblin B, McMahon L, Nair A, Thomas MB, Wakefield J, Koentgen F, Ramabhadran R. Novel approaches to models of Alzheimer's disease pathology for drug screening and development. J Mol Neurosci. .24(1):23-32, 2004. PMID: 15314246
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47.Thomas MB, Koller C, Yang Y, Shen Y, O'Brien S, Kantarjian H, Davis J, Estey E. Comparison of fludarabine-containing salvage chemotherapy regimens for relapsed/refractory acute myelogenous leukemia. Leukemia. .17(5):990-3, 2003. PMID: 12750721
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