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Lewis J Frey, PhD
Associate Professor of Public Health Sciences
College of Medicine
MUSC

Email: frey@musc.edu
 
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Lewis J Frey, PhD

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Research Interest:

My research interests include the development of novel algorithms and information systems for the purpose of discovery and data integration applicable to precision medicine. In addition to applying novel machine learning to medically relevant data, my information systems approach combines the accumulated wealth of knowledge that exists in medical record systems with the vast amounts of molecular data being captured with high-throughput measurement technologies. Currently, I am focused on the investigation of the utility of novel similarity measures to conduct predictive analytics.

Selected Publications:

1.Frey LJ, Sward KA, Newth CJ, Khemani RG, Cryer ME, Thelen JL, Enriquez R, Shaoyu S, Pollack MM, Harrison RE, Meert KL, Berg RA, Wessel DL, Shanley TP, Dalton H, Carcillo J, Jenkins TL, Dean JM. Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network. J Am Med Inform Assoc. .22(6):1271-6, 2015. PMID: 25796596 PMCID: PMC4639713
View in: PubMed

2.Luo G, Frey LJ. Efficient Execution Methods of Pivoting for Bulk Extraction of Entity-Attribute-Value-Modeled Data. IEEE J Biomed Health Inform. ., 2015. PMID: 25608318
View in: PubMed

3.Frey LJ. Informatics tools to advance the biology of glycosaminoglycans and proteoglycans. Methods Mol Biol. .1229:271-87, 2015. PMID: 25325960
View in: PubMed

4.Frey LJ, Lenert L, Lopez-Campos G. EHR Big Data Deep Phenotyping. Contribution of the IMIA Genomic Medicine Working Group. Yearb Med Inform. .9:206-11, 2014. PMID: 25123744 PMCID: PMC4287080
View in: PubMed

5.Guo JW, Sward K, Beck S, Wong B, Staggers N, Frey L. Using a content analysis to identify study eligibility criteria concepts in cancer nursing research. Comput Inform Nurs. .32(7):333-42, 2014. PMID: 24814997
View in: PubMed

6.Thibault JC, Frey L. Biomedical Terminology Mapper for UML projects. AMIA Jt Summits Transl Sci Proc. .2013:257-61, 2013. PMID: 24303278 PMCID: PMC3845744
View in: PubMed

7.Piccolo SR, Frey LJ. Clinical and molecular models of glioblastoma multiforme survival. Int J Data Min Bioinform. .7(3):245-65, 2013. PMID: 23819258 PMCID: PMC4018825
View in: PubMed

8.Frey LJ, Piccolo SR, Edgerton ME. Multiplicity: an organizing principle for cancers and somatic mutations. BMC Med Genomics. .4:52, 2011. PMID: 21714919 PMCID: PMC3150236
View in: PubMed

9.Cryer ME, Frey L. Agent-based modeling supporting the migration of registry systems to grid based architectures. Summit on Translat Bioinforma. .2009:26-30, 2009. PMID: 21347166 PMCID: PMC3041565
View in: PubMed

10.Kunz I, Lin MC, Frey L. Metadata mapping and reuse in caBIG. BMC Bioinformatics. .10 Suppl 2:S4, 2009. PMID: 19208192 PMCID: PMC2646244
View in: PubMed

11.Piccolo SR, Camp N, Frey LJ. Polygenic model for predicting breast cancer risk via genome-wide polymorphisms. AMIA Annu Symp Proc. .1094, 2008. PMID: 18999159
View in: PubMed

12.Piccolo SR, Frey LJ. Somatic mutation signatures of cancer. AMIA Annu Symp Proc. .202-6, 2008. PMID: 18999255 PMCID: PMC2655983
View in: PubMed

13.Edgerton ME, Fisher DH, Tang L, Frey LJ, Chen Z. Data mining for gene networks relevant to poor prognosis in lung cancer via backward-chaining rule induction. Cancer Inform. .3:93-114, 2007. PMID: 19455237 PMCID: PMC2312096
View in: PubMed

14.Frey LJ, Maojo V, Mitchell JA. Bioinformatics linkage of heterogeneous clinical and genomic information in support of personalized medicine. Yearb Med Inform. .98-105, 2007. PMID: 17700912
View in: PubMed

15.Frey L, Edgerton M, Fisher D, Levy S. Ensemble stump classifiers and gene expression signatures in lung cancer. Stud Health Technol Inform. .129(Pt 2):1255-9, 2007. PMID: 17911916
View in: PubMed

16.Frey L, Edgerton ME, Fisher DH, Tang L, Chen Z. Using prior knowledge and rule induction methods to discover molecular markers of prognosis in lung cancer. AMIA Annu Symp Proc. .256-60, 2005. PMID: 16779041 PMCID: PMC1560786
View in: PubMed

17.Kalyanaraman VS, Mahadevan S, Kumar SA. Oxidase-peroxidase enzymes of Datura innoxia. Oxidation of formylphenylacetic acid ethyl ester. Biochem J. .149(3):565-76, 1975. PMID: 997 PMCID: PMC1165663
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18.Dunkerton J, James SP. Purification of 2-oxoaldehyde dehydrogenase and its dependence on unusual amines. Biochem J. .149(3):609-17, 1975. PMID: 998 PMCID: PMC1165667
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