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Charles D Smith, PhD
Professor of Drug Discovery & Biomedical Sciences
College of Pharmacy
MUSC

Email: smithchd@musc.edu
 
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Charles D Smith, PhD

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Research Interest:

My research interests center on drug discovery and molecular pharmacology, particularly relating to sphingolipid signaling systems involved in cancer and inflammation. My research has produced more than 120 publications and multiple US and international patents, mostly focused on the identification of new targets for chemotherapy, and the design, synthesis and evaluation of new drug candidates. In the past several years, my laboratory focused on new targets in the sphingolipid metabolism pathway, including the sphingosine kinases and ceramidases that regulate tumor growth. In addition to my academic work, I am the Founder of Apogee Biotechnology Corporation, a drug discovery company that is developing proprietary compounds for the treatment of cancer and other diseases. Apogee is currently testing the first-in-class sphingosine kinase-2 inhibitor (ABC294640) in cancer patients at the Medical University of South Carolina.

Honors:
Endowed Chair in Cancer Drug Discovery, SmartState Center of Economic Excellence, Medical University of South Carolina, Charleston, SC

Positions:
Director, Drug Discovery & Screening Shared Resource, Hollings Cancer Center, Medical University of South Carolina

Selected Publications:

1.Jones EE, Gao P, Smith CD, Norris JS, Drake RR. Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow. Bioanalysis. .7(20):2611-9, 2015. PMID: 26505686
View in: PubMed

2.Venant H, Rahmaniyan M, Jones EE, Lu P, Lilly MB, Garrett-Mayer E, Drake RR, Kraveka JM, Smith CD, Voelkel-Johnson C. The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo. Mol Cancer Ther. .14(12):2744-52, 2015. PMID: 26494858 PMCID: PMC4674301
View in: PubMed

3.Ighodaro ET, Jicha GA, Schmitt FA, Neltner JH, Abner EL, Kryscio RJ, Smith CD, Duplessis T, Anderson S, Patel E, Bachstetter A, Van Eldik LJ, Nelson PT. Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature. J Neuropathol Exp Neurol. .74(7):642-52, 2015. PMID: 26083567 PMCID: PMC4539239
View in: PubMed

4.Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Sci Signal. .8(381):ra58, 2015. PMID: 26082434 PMCID: PMC4492107
View in: PubMed

5.Venkata JK, An N, Stuart R, Costa LJ, Cai H, Coker W, Song JH, Gibbs K, Matson T, Garrett-Mayer E, Wan Z, Ogretmen B, Smith C, Kang Y. Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. Blood. .124(12):1915-25, 2014. PMID: 25122609 PMCID: PMC4168346
View in: PubMed

6.Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C. Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem. .289(30):20845-57, 2014. PMID: 24928515 PMCID: PMC4110292
View in: PubMed

7.Dai L, Plaisance-Bonstaff K, Voelkel-Johnson C, Smith CD, Ogretmen B, Qin Z, Parsons C. Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells. PLoS One. .9(7):e102314, 2014. PMID: 25010828 PMCID: PMC4092155
View in: PubMed

8.Qin Z, Dai L, Trillo-Tinoco J, Senkal C, Wang W, Reske T, Bonstaff K, Del Valle L, Rodriguez P, Flemington E, Voelkel-Johnson C, Smith CD, Ogretmen B, Parsons C. Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Mol Cancer Ther. .13(1):154-64, 2013. PMID: 24140934 PMCID: PMC3918494
View in: PubMed

9.Abdulghani J, Allen JE, Dicker DT, Liu YY, Goldenberg D, Smith CD, Humphreys R, El-Deiry WS. Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcl1 axis. PLoS One. .8(9):e75414, 2013. PMID: 24086526 PMCID: PMC3784419
View in: PubMed

10.Schwartz J, Holmuhamedov E, Zhang X, Lovelace GL, Smith CD, Lemasters JJ. Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol. .273(1):172-9, 2013. PMID: 24012766 PMCID: PMC4402227
View in: PubMed

11.Russell WS, Schuh AM, Hill JG, Hebra A, Cina RA, Smith CD, Streck CJ. Clinical practice guidelines for pediatric appendicitis evaluation can decrease computed tomography utilization while maintaining diagnostic accuracy. Pediatr Emerg Care. .29(5):568-73, 2013. PMID: 23611916
View in: PubMed

12.Gangjee A, Kurup S, Smith CD. Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors. Bioorg Med Chem. .21(5):1180-9, 2013. PMID: 23352482 PMCID: PMC3582361
View in: PubMed

13.Titchenell PM, Lin CM, Keil JM, Sundstrom JM, Smith CD, Antonetti DA. Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction. Biochem J. .446(3):455-67, 2012. PMID: 22721706 PMCID: PMC3767384
View in: PubMed

14.Gao P, Peterson YK, Smith RA, Smith CD. Characterization of isoenzyme-selective inhibitors of human sphingosine kinases. PLoS One. .7(9):e44543, 2012. PMID: 22970244 PMCID: PMC3438171
View in: PubMed

15.Baker DA, Eudaly J, Smith CD, Obeid LM, Gilkeson GS. Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis. Rheumatol Int. .33(10):2677-81, 2012. PMID: 23011090 PMCID: PMC3784643
View in: PubMed

16.Liu Q, Rehman H, Shi Y, Krishnasamy Y, Lemasters JJ, Smith CD, Zhong Z. Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One. .7(7):e41834, 2012. PMID: 22848628 PMCID: PMC3405047
View in: PubMed

17.Sun WY, Abeynaike LD, Escarbe S, Smith CD, Pitson SM, Hickey MJ, Bonder CS. Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent. Am J Pathol. .180(4):1740-50, 2012. PMID: 22322303
View in: PubMed

18.Yung LM, Wei Y, Qin T, Wang Y, Smith CD, Waeber C. Sphingosine kinase 2 mediates cerebral preconditioning and protects the mouse brain against ischemic injury. Stroke. .43(1):199-204, 2011. PMID: 21980199 PMCID: PMC3246529
View in: PubMed

19.Gao P, Smith CD. Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration. Mol Cancer Res. .9(11):1509-19, 2011. PMID: 21896638 PMCID: PMC3219805
View in: PubMed

20.Draper JM, Xia Z, Smith RA, Zhuang Y, Wang W, Smith CD. Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. .10(11):2052-61, 2011. PMID: 21885864 PMCID: PMC3213284
View in: PubMed

21.Wang W, Gallant JN, Katz SI, Dolloff NG, Smith CD, Abdulghani J, Allen JE, Dicker DT, Hong B, Navaraj A, El-Deiry WS. Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents. Cancer Biol Ther. .12(3):229-38, 2011. PMID: 21725212
View in: PubMed

22.Gallant JN, Allen JE, Smith CD, Dicker DT, Wang W, Dolloff NG, Navaraj A, El-Deiry WS. Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer. Cancer Biol Ther. .12(3):239-51, 2011. PMID: 21725213
View in: PubMed

23.Shi Y, Rehman H, Ramshesh VK, Schwartz J, Liu Q, Krishnasamy Y, Zhang X, Lemasters JJ, Smith CD, Zhong Z. Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. J Hepatol. .56(1):137-45, 2011. PMID: 21756852 PMCID: PMC3220779
View in: PubMed

24.Smith CD. Your idea and your university: issues in academic technology transfer. J Investig Med. .59(5):752-7, 2011. PMID: 21245769 PMCID: PMC3660085
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25.Gangjee A, Namjoshi OA, Keller SN, Smith CD. 2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance. Bioorg Med Chem. .19(14):4355-65, 2011. PMID: 21680190 PMCID: PMC3138178
View in: PubMed

26.Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, Baran Y, Mahajan S, Fernandes D, Stuart R, Perrotti D, Ogretmen B. Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. .117(22):5941-52, 2011. PMID: 21527515 PMCID: PMC3112039
View in: PubMed

27.Antoon JW, White MD, Slaughter EM, Driver JL, Khalili HS, Elliott S, Smith CD, Burow ME, Beckman BS. Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2. Cancer Biol Ther. .11(7):678-89, 2011. PMID: 21307639 PMCID: PMC3084971
View in: PubMed

28.Beljanski V, Lewis CS, Smith CD. Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. Cancer Biol Ther. .11(5):524-34, 2011. PMID: 21258214 PMCID: PMC3087901
View in: PubMed

29.Fitzpatrick LR, Green C, Maines LW, Smith CD. Experimental osteoarthritis in rats is attenuated by ABC294640, a selective inhibitor of sphingosine kinase-2. Pharmacology. .87(3-4):135-43, 2011. PMID: 21346391
View in: PubMed

30.Beharry Z, Mahajan S, Zemskova M, Lin YW, Tholanikunnel BG, Xia Z, Smith CD, Kraft AS. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. .108(2):528-33, 2010. PMID: 21187426 PMCID: PMC3021022
View in: PubMed

31.Fitzpatrick LR, Green C, Frauenhoffer EE, French KJ, Zhuang Y, Maines LW, Upson JJ, Paul E, Donahue H, Mosher TJ, Smith CD. Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. Inflammopharmacology. .19(2):75-87, 2010. PMID: 20936538
View in: PubMed

32.Antoon JW, White MD, Meacham WD, Slaughter EM, Muir SE, Elliott S, Rhodes LV, Ashe HB, Wiese TE, Smith CD, Burow ME, Beckman BS. Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640. Endocrinology. .151(11):5124-35, 2010. PMID: 20861237 PMCID: PMC2954724
View in: PubMed

33.Chumanevich AA, Poudyal D, Cui X, Davis T, Wood PA, Smith CD, Hofseth LJ. Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. Carcinogenesis. .31(10):1787-93, 2010. PMID: 20688834 PMCID: PMC2981458
View in: PubMed

34.McGowan J, Smith CD, Maize J, Cook J. Giant fibrous hamartoma of infancy: a report of two cases and review of the literature. J Am Acad Dermatol. .64(3):579-86, 2010. PMID: 20598395
View in: PubMed

35.Beljanski V, Knaak C, Zhuang Y, Smith CD. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs. .29(6):1132-42, 2010. PMID: 20473784 PMCID: PMC3089696
View in: PubMed

36.Draper JM, Smith CD. DHHC20: a human palmitoyl acyltransferase that causes cellular transformation. Mol Membr Biol. .27(2-3):123-36, 2010. PMID: 20334580 PMCID: PMC2893407
View in: PubMed

37.Beljanski V, Knaak C, Smith CD. A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J Pharmacol Exp Ther. .333(2):454-64, 2010. PMID: 20179157 PMCID: PMC2872961
View in: PubMed

38.Maines LW, Fitzpatrick LR, Green CL, Zhuang Y, Smith CD. Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease. Inflammopharmacology. .18(2):73-85, 2010. PMID: 20151210
View in: PubMed

39.French KJ, Zhuang Y, Maines LW, Gao P, Wang W, Beljanski V, Upson JJ, Green CL, Keller SN, Smith CD. Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther. .333(1):129-39, 2010. PMID: 20061445 PMCID: PMC2846016
View in: PubMed

40.Xia Z, Draper JM, Smith CD. Improved synthesis of a fluorogenic ceramidase substrate. Bioorg Med Chem. .18(3):1003-9, 2010. PMID: 20085856 PMCID: PMC2841511
View in: PubMed

41.Katz SI, Zhou L, Chao G, Smith CD, Ferrara T, Wang W, Dicker DT, El-Deiry WS. Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. Cancer Biol Ther. .8(24):2406-16, 2009. PMID: 20038816 PMCID: PMC3052759
View in: PubMed

42.Lin YW, Beharry ZM, Hill EG, Song JH, Wang W, Xia Z, Zhang Z, Aplan PD, Aster JC, Smith CD, Kraft AS. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. .115(4):824-33, 2009. PMID: 19965690 PMCID: PMC2941996
View in: PubMed

43.Beharry Z, Zemskova M, Mahajan S, Zhang F, Ma J, Xia Z, Lilly M, Smith CD, Kraft AS. Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. Mol Cancer Ther. .8(6):1473-83, 2009. PMID: 19509254 PMCID: PMC3415237
View in: PubMed

44.Zhang F, Beharry ZM, Harris TE, Lilly MB, Smith CD, Mahajan S, Kraft AS. PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells. Cancer Biol Ther. .8(9):846-53, 2009. PMID: 19276681
View in: PubMed

45.Draper JM, Smith CD. Palmitoyl acyltransferase assays and inhibitors (Review). Mol Membr Biol. .26(1):5-13, 2009. PMID: 19152182 PMCID: PMC2635919
View in: PubMed

46.Xia Z, Knaak C, Ma J, Beharry ZM, McInnes C, Wang W, Kraft AS, Smith CD. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. .52(1):74-86, 2009. PMID: 19072652
View in: PubMed

47.Tran MA, Smith CD, Kester M, Robertson GP. Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development. Clin Cancer Res. .14(11):3571-81, 2008. PMID: 18519791
View in: PubMed

48.Lesher AP, Kratz JM, Smith CD. Removal of embedded central venous catheters. J Pediatr Surg. .43(6):1030-4, 2008. PMID: 18558178
View in: PubMed

49.Seaton KE, Smith CD. N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. J Gen Virol. .89(Pt 1):288-96, 2008. PMID: 18089753 PMCID: PMC2888270
View in: PubMed

50.Maines LW, Fitzpatrick LR, French KJ, Zhuang Y, Xia Z, Keller SN, Upson JJ, Smith CD. Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase. Dig Dis Sci. .53(4):997-1012, 2007. PMID: 18058233 PMCID: PMC2660406
View in: PubMed

51.Plastaras JP, Kim SH, Liu YY, Dicker DT, Dorsey JF, McDonough J, Cerniglia G, Rajendran RR, Gupta A, Rustgi AK, Diehl JA, Smith CD, Flaherty KT, El-Deiry WS. Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation. Cancer Res. .67(19):9443-54, 2007. PMID: 17909054
View in: PubMed

52.Hall MA, Cleveland JL. Clearing the TRAIL for Cancer Therapy. Cancer Cell. .12(1):4-6, 2007. PMID: 17613431
View in: PubMed

53.Gangjee A, Yu J, Copper JE, Smith CD. Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. J Med Chem. .50(14):3290-301, 2007. PMID: 17567121 PMCID: PMC3858178
View in: PubMed

54.Draper JM, Xia Z, Smith CD. Cellular palmitoylation and trafficking of lipidated peptides. J Lipid Res. .48(8):1873-84, 2007. PMID: 17525474 PMCID: PMC2895159
View in: PubMed

55.Maines LW, French KJ, Wolpert EB, Antonetti DA, Smith CD. Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. Invest Ophthalmol Vis Sci. .47(11):5022-31, 2006. PMID: 17065523 PMCID: PMC2660407
View in: PubMed

56.Ducker CE, Draper JM, Xia Z, Smith CD. In vitro and cellular assays for palmitoyl acyltransferases using fluorescent lipidated peptides. Methods. .40(2):166-70, 2006. PMID: 17012028 PMCID: PMC2892119
View in: PubMed

57.Sharma A, Tran MA, Liang S, Sharma AK, Amin S, Smith CD, Dong C, Robertson GP. Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases. Cancer Res. .66(16):8200-9, 2006. PMID: 16912199 PMCID: PMC2777627
View in: PubMed

58.Ducker CE, Griffel LK, Smith RA, Keller SN, Zhuang Y, Xia Z, Diller JD, Smith CD. Discovery and characterization of inhibitors of human palmitoyl acyltransferases. Mol Cancer Ther. .5(7):1647-59, 2006. PMID: 16891450 PMCID: PMC2888271
View in: PubMed

59.French KJ, Upson JJ, Keller SN, Zhuang Y, Yun JK, Smith CD. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther. .318(2):596-603, 2006. PMID: 16632640
View in: PubMed

60.Maines LW, Antonetti DA, Wolpert EB, Smith CD. Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. Neuropharmacology. .49(5):610-7, 2005. PMID: 15961125
View in: PubMed

61.Terracciano S, Bruno I, Bifulco G, Avallone E, Smith CD, Gomez-Paloma L, Riccio R. Synthesis, solution structure, and bioactivity of six new simplified analogues of the natural cyclodepsipeptide jaspamide. Bioorg Med Chem. .13(17):5225-39, 2005. PMID: 16023351
View in: PubMed

62.Ducker CE, Upson JJ, French KJ, Smith CD. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. Mol Cancer Res. .3(8):463-76, 2005. PMID: 16123142 PMCID: PMC2908404
View in: PubMed

63.Sharma A, Trivedi NR, Zimmerman MA, Tuveson DA, Smith CD, Robertson GP. Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res. .65(6):2412-21, 2005. PMID: 15781657
View in: PubMed

64.Ducker CE, Stettler EM, French KJ, Upson JJ, Smith CD. Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. Oncogene. .23(57):9230-7, 2004. PMID: 15489887 PMCID: PMC2908390
View in: PubMed

65.Terracciano S, Bruno I, Bifulco G, Copper JE, Smith CD, Gomez-Paloma L, Riccio R. Synthesis, conformational analysis, and cytotoxicity of new analogues of the natural cyclodepsipeptide jaspamide. J Nat Prod. .67(8):1325-31, 2004. PMID: 15332850
View in: PubMed

66.Lee BD, Li Z, French KJ, Zhuang Y, Xia Z, Smith CD. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. .47(6):1413-22, 2004. PMID: 14998330
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67.French KJ, Zhuang Y, Schrecengost RS, Copper JE, Xia Z, Smith CD. Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1. J Pharmacol Exp Ther. .309(1):340-7, 2004. PMID: 14724220
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68.Hiol A, Caron JM, Smith CD, Jones TL. Characterization and partial purification of protein fatty acyltransferase activity from rat liver. Biochim Biophys Acta. .1635(1):10-9, 2003. PMID: 14642772
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69.French KJ, Schrecengost RS, Lee BD, Zhuang Y, Smith SN, Eberly JL, Yun JK, Smith CD. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. .63(18):5962-9, 2003. PMID: 14522923
View in: PubMed

70.Varner AS, Ducker CE, Xia Z, Zhuang Y, De Vos ML, Smith CD. Characterization of human palmitoyl-acyl transferase activity using peptides that mimic distinct palmitoylation motifs. Biochem J. .373(Pt 1):91-9, 2003. PMID: 12670300 PMCID: PMC1223475
View in: PubMed

71.Lee BD, French KJ, Zhuang Y, Smith CD. Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator, PGP-4008. Oncol Res. .14(1):49-60, 2003. PMID: 14552591
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72.Varner AS, De Vos ML, Creaser SP, Peterson BR, Smith CD. A fluorescence-based high performance liquid chromatographic method for the characterization of palmitoyl acyl transferase activity. Anal Biochem. .308(1):160-7, 2002. PMID: 12234477
View in: PubMed

73.Smith CD, Tecklenburg FW, Habib DM, Hughes MR, Hulsey TC, Ebeling M. Success factors and hurdles in quality improvement in a children's hospital. Semin Pediatr Surg. .11(1):12-9, 2002. PMID: 11815936
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74.De Vos ML, Lawrence DS, Smith CD. Cellular pharmacology of cerulenin analogs that inhibit protein palmitoylation. Biochem Pharmacol. .62(8):985-95, 2001. PMID: 11597568
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75.Xia Z, Smith CD. Efficient synthesis of a fluorescent farnesylated Ras peptide. J Org Chem. .66(15):5241-4, 2001. PMID: 11463279
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76.Xia Z, Smith CD. Total synthesis of dendroamide A, a novel cyclic peptide that reverses multiple drug resistance. J Org Chem. .66(10):3459-66, 2001. PMID: 11348130
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77.Lawrence DS, Copper JE, Smith CD. Structure-activity studies of substituted quinoxalinones as multiple-drug-resistance antagonists. J Med Chem. .44(4):594-601, 2001. PMID: 11170649
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78.Smith CD, Myers CB, Zilfou JT, Smith SN, Lawrence DS. Indoloquinoxaline compounds that selectively antagonize P-glycoprotein. Oncol Res. .12(5):219-29, 2000. PMID: 11417747
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79.Lawrence DS, Zilfou JT, Smith CD. Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors. J Med Chem. .42(24):4932-41, 1999. PMID: 10585203
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80.Morlière P, Mazière JC, Santus R, Smith CD, Prinsep MR, Stobbe CC, Fenning MC, Golberg JL, Chapman JD. Tolyporphin: a natural product from cyanobacteria with potent photosensitizing activity against tumor cells in vitro and in vivo. Cancer Res. .58(16):3571-8, 1998. PMID: 9721863
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81.Dinh TQ, Smith CD, Du X, Armstrong RW. Design, synthesis, and evaluation of the multidrug resistance-reversing activity of D-glucose mimetics of hapalosin. J Med Chem. .41(6):981-7, 1998. PMID: 9526572
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82.Zhang X, Minale L, Zampella A, Smith CD. Microfilament depletion and circumvention of multiple drug resistance by sphinxolides. Cancer Res. .57(17):3751-8, 1997. PMID: 9288783
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83.Smith CD, Zhang X. Mechanism of action cryptophycin. Interaction with the Vinca alkaloid domain of tubulin. J Biol Chem. .271(11):6192-8, 1996. PMID: 8626409
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84.Zhang X, Smith CD. Microtubule effects of welwistatin, a cyanobacterial indolinone that circumvents multiple drug resistance. Mol Pharmacol. .49(2):288-94, 1996. PMID: 8632761
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85.Smith CD, Zilfou JT, Stratmann K, Patterson GM, Moore RE. Welwitindolinone analogues that reverse P-glycoprotein-mediated multiple drug resistance. Mol Pharmacol. .47(2):241-7, 1995. PMID: 7870031
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86.Smith CD, Zhang X, Mooberry SL, Patterson GM, Moore RE. Cryptophycin: a new antimicrotubule agent active against drug-resistant cells. Cancer Res. .54(14):3779-84, 1994. PMID: 7913408
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87.Smith CD, Carmeli S, Moore RE, Patterson GM. Scytophycins, novel microfilament-depolymerizing agents which circumvent P-glycoprotein-mediated multidrug resistance. Cancer Res. .53(6):1343-7, 1993. PMID: 8095179
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