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Kevin F Staveley-O'Carroll, MD, PhD
Professor of Surgery
College of Medicine
MUSC

Email: staveley@musc.edu
 
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Kevin F Staveley-O'Carroll, MD, PhD

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Research Interest:

As a physician-scientist, one goal has been to translate my basic research into clinical practice.  My studies assessing the effects of opioid growth factor on the growth of hepatocellular cancer have led directly to an investigator-initiated Phase I clinical trial that is nearing completion. My studies of ceramide nanoliposomes’ in vivo inhibition of hepatocellular cancer (Gut, 2010, IF-10.6, featured in Nature Reviews) will be assessed in Phase I clinical trial pending FDA approval of the IND application. I also have clinical protocols assessing the changes in the immune-response to HCC antigens, AFP and GPC-3, which occur with radiofrequency ablation or chemoembolization in patients with hepatocellular cancer. My current project has been conceived with similar translational goals in mind and was funded by the NIH to elucidate the cellular and molecular mechanisms by which the chemotherapeutic agent sunitinib prevents immunotolerance and enhances T-cell mediated immunotherapy of hepatocellular cancer. I have established a unique murine model with the typical fibrosis/cirrhosis and hepatocellular cancer features seen in human hepatocellular cancer. My team has now demonstrated that tumor antigen-specific CD8 T-cell tolerance is prevented by the administration of sunitinib, an FDA approved inhibitor of multiple receptor tyrosine kinases. Moreover, we made the critical observation that sunitinib combined with adoptive transfer of CD8 T-cells leads to durable long term regression of established hepatocellular cancer tumors. These results suggest that sunitinib blocks the development of an immunosuppressive state within the liver, allowing effective immunotherapy. This study will advance our knowledge of the sunitinib-mediated mechanisms of action on distinct immune cell subsets in the setting of hepatocellular cancer. The knowledge gained will lay the foundation for translational approaches in human hepatocellular cancer that combines this chemotherapeutic drug with new or existing immunotherapies.

Honors:
Alice Ruth Reeves Folk Endowed Chair of Clinical Oncology

Positions:
Chief, Section of Surgical Oncology, Department of Surgery, Medical University of South Carolina
Medical Director, Hollings Cancer Center Clinical Service Line, Medical University of South Carolina
Director, Cell Evaluation & Therapy Shared Resource, Hollings Cancer Center, Medical University of South Carolina

Selected Publications:

1.Qi X, Li G, Liu D, Motamarry A, Huang X, Wolfe AM, Helke KL, Haemmerich D, Staveley-O'Carroll KF, Kimchi ET. Development of a radiofrequency ablation platform in a clinically relevant murine model of hepatocellular cancer. Cancer Biol Ther. .16(12):1812-9, 2015. PMID: 26537481
View in: PubMed

2.Johnson CB, Riesenberg BP, May BR, Gilreath SC, Li G, Staveley-O'Carroll KF, Garrett-Mayer E, Mehrotra S, Cole DJ, Rubinstein MP. Effector CD8+ T-cell Engraftment and Antitumor Immunity in Lymphodepleted Hosts Is IL7Ra Dependent. Cancer Immunol Res. ., 2015. PMID: 26297711
View in: PubMed

3.Lu S, Zhang J, Liu D, Li G, Staveley-O'Carroll KF, Li Z, Wu JD. Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors. Clin Cancer Res. .21(21):4819-30, 2015. PMID: 26106076 PMCID: PMC4631684
View in: PubMed

4.Anderson BJ, Hill EG, Sweeney RE, Wahlquist AE, Marshall DT, Staveley O'Carroll KF, Cole DJ, Camp ER. The impact of surgical diversion before neoadjuvant therapy for rectal cancer. Am Surg. .81(5):444-9, 2015. PMID: 25975325
View in: PubMed

5.Avella DM, Toth JW, Reed MF, Gusani NJ, Kimchi ET, Mahraj RP, Staveley-O'Carroll KF, Kaifi JT. Pleural space infections after image-guided percutaneous drainage of infected intraabdominal fluid collections: a retrospective single institution analysis. BMC Surg. .15:42, 2015. PMID: 25881169 PMCID: PMC4396552
View in: PubMed

6.Kaifi JT, Kunkel M, Dicker DT, Joude J, Allen JE, Das A, Zhu J, Yang Z, Sarwani NE, Li G, Staveley-O'Carroll KF, El-Deiry WS. Circulating tumor cell levels are elevated in colorectal cancer patients with high tumor burden in the liver. Cancer Biol Ther. .16(5):690-8, 2015. PMID: 25785486 PMCID: PMC4622723
View in: PubMed

7.Kaifi JT, Kunkel M, Das A, Harouaka RA, Dicker DT, Li G, Zhu J, Clawson GA, Yang Z, Reed MF, Gusani NJ, Kimchi ET, Staveley-O'Carroll KF, Zheng SY, El-Deiry WS. Circulating tumor cell isolation during resection of colorectal cancer lung and liver metastases: a prospective trial with different detection techniques. Cancer Biol Ther. .16(5):699-708, 2015. PMID: 25807199 PMCID: PMC4622016
View in: PubMed

8.Bhayani NH, Jiang Y, Hamed O, Kimchi ET, Staveley-O'Carroll KF, Gusani NJ. Advances in the Pharmacologic Treatment of Hepatocellular Carcinoma. Curr Clin Pharmacol. .10(4):299-304, 2015. PMID: 26548906
View in: PubMed

9.Findlay VJ, Wang C, Nogueira LM, Hurst K, Quirk D, Ethier SP, Staveley O'Carroll KF, Watson DK, Camp ER. SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression. Mol Cancer Ther. .13(11):2713-26, 2014. PMID: 25249558 PMCID: PMC4221636
View in: PubMed

10.Kulaylat AN, Bhayani NH, Stokes AL, Schubart JR, Wong J, Kimchi ET, Staveley-O'Carroll KF, Kaifi JT, Gusani NJ. Determinants of repeat curative intent surgery in colorectal liver metastasis. J Gastrointest Surg. .18(11):1894-901, 2014. PMID: 24950776
View in: PubMed

11.Jiang Y, Mackley HB, Kimchi ET, Zhu J, Gusani N, Kaifi J, Staveley-O'Carroll KF, Belani CP. Phase I dose escalation study of capecitabine and erlotinib concurrent with radiation in locally advanced pancreatic cancer. Cancer Chemother Pharmacol. .74(1):205-10, 2014. PMID: 24908435
View in: PubMed

12.Yoo L, Oluyemi A, Dye C, Staveley-O'Carroll K, Mathew A. Removal of a partially prolapsing intraductal ampullar adenoma. Gastrointest Endosc. .79(3):377, 2014. PMID: 24528824
View in: PubMed

13.Nikfarjam M, Weinberg L, Fink MA, Muralidharan V, Starkey G, Jones R, Staveley-O'Carroll K, Christophi C. Pressurized pulse irrigation with saline reduces surgical-site infections following major hepatobiliary and pancreatic surgery: randomized controlled trial. World J Surg. .38(2):447-55, 2014. PMID: 24170152
View in: PubMed

14.Bhayani NH, Enomoto LM, James BC, Ortenzi G, Kaifi JT, Kimchi ET, Staveley-O'Carroll KF, Gusani NJ. Multivisceral and extended resections during pancreatoduodenectomy increase morbidity and mortality. Surgery. .155(3):567-74, 2013. PMID: 24524390
View in: PubMed

15.Kline CL, Schiccitano A, Zhu J, Beachler C, Sheikh H, Harvey HA, Mackley HB, McKenna K, Staveley-O'Carroll K, Poritz L, Messaris E, Stewart D, Sivik J, El-Deiry WS. Personalized dosing via pharmacokinetic monitoring of 5-fluorouracil might reduce toxicity in early- or late-stage colorectal cancer patients treated with infusional 5-fluorouracil-based chemotherapy regimens. Clin Colorectal Cancer. .13(2):119-26, 2013. PMID: 24461492
View in: PubMed

16.Bhayani NH, Miller JL, Ortenzi G, Kaifi JT, Kimchi ET, Staveley-O'Carroll KF, Gusani NJ. Perioperative outcomes of pancreaticoduodenectomy compared to total pancreatectomy for neoplasia. J Gastrointest Surg. .18(3):549-54, 2013. PMID: 24165872
View in: PubMed

17.Kaifi JT, Kunkel M, Zhu J, Dicker DT, Gusani N, Yang Z, Sarwani NE, Li G, Kimchi ET, Staveley-O'Carroll KF, El-Deiry WS. Circulating tumor cells are associated with diffuse spread in stage IV colorectal cancer patients. Cancer Biol Ther. .14(12):1174-81, 2013. PMID: 24153154 PMCID: PMC3912041
View in: PubMed

18.Bhayani NH, Enomoto LM, Miller JL, Ortenzi G, Kaifi JT, Kimchi ET, Staveley-O'Carroll KF, Gusani NJ. Morbidity of total pancreatectomy with islet cell auto-transplantation compared to total pancreatectomy alone. HPB (Oxford). .16(6):522-7, 2013. PMID: 23992021 PMCID: PMC4048073
View in: PubMed

19.Kulaylat AN, Sahajwani S, Staveley-O'Carroll KF, Kaifi JT. Reconstructive options for gastroesophageal junction adenocarcinoma after Roux-en-Y gastric bypass. J Thorac Cardiovasc Surg. .146(5):1296-8, 2013. PMID: 23988286
View in: PubMed

20.Bhayani NH, Hamed OH, Gupta A, Ortenzi G, Kaifi JT, Kimchi ET, Staveley-O'Carroll KF, Gusani NJ. Do patients' outcomes suffer when surgical fellows are involved in hepatic resection? Surgery. .154(5):1024-30, 2013. PMID: 23891478
View in: PubMed

21.Lim B, Scicchitano A, Beachler C, Gusani N, Sarwani N, Yang Z, Staveley-O'Carroll K, Ashkenazi A, Portera C, El-Deiry WS. FOLFIRI plus dulanermin (rhApo2L/TRAIL) in a patient with BRAF-mutant metastatic colon cancer. Cancer Biol Ther. .14(8):711-9, 2013. PMID: 23792567 PMCID: PMC3841210
View in: PubMed

22.Kavuturu S, Sarwani NE, Ruggeiro FM, Deshaies I, Kimchi ET, Kaifi JT, Staveley-O'Carroll KF, Gusani NJ. Lymphoepithelial cysts of the pancreas. Can preoperative imaging distinguish this benign lesion from malignant or pre-malignant cystic pancreatic lesions? JOP. .14(3):250-5, 2013. PMID: 23669473
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23.Hamed O, Kimchi ET, Sehmbey M, Gusani NJ, Kaifi JT, Staveley-O'Carroll K. Impact of genetic targets on cancer therapy: hepatocellular cancer. Adv Exp Med Biol. .779:67-90, 2013. PMID: 23288636
View in: PubMed

24.Hamed OH, Bhayani NH, Ortenzi G, Kaifi JT, Kimchi ET, Staveley-O'Carroll KF, Gusani NJ. Simultaneous colorectal and hepatic procedures for colorectal cancer result in increased morbidity but equivalent mortality compared with colorectal or hepatic procedures alone: outcomes from the National Surgical Quality Improvement Program. HPB (Oxford). .15(9):695-702, 2012. PMID: 23458152 PMCID: PMC3948537
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25.Kaifi JT, Kibbe MR, LeMaire SA, Staveley-O'Carroll KF, Kao LS, Sosa JA, Kimchi ET, Pawlik TM, Gusani NJ. Scientific impact of Association for Academic Surgery and Society of University Surgeons plenary session abstracts increases in the era of the Academic Surgical Congress from 2006 to 2010. J Surg Res. .182(1):6-10, 2012. PMID: 22954524
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26.Pauli EM, Staveley-O'Carroll KF, Brock MV, Efron DT, Efron G. A handy tool to teach segmental liver anatomy to surgical trainees. Arch Surg. .147(8):692-3, 2012. PMID: 22911067 PMCID: PMC4061562
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27.Clawson GA, Kimchi E, Patrick SD, Xin P, Harouaka R, Zheng S, Berg A, Schell T, Staveley-O'Carroll KF, Neves RI, Mosca PJ, Thiboutot D. Circulating tumor cells in melanoma patients. PLoS One. .7(7):e41052, 2012. PMID: 22829910 PMCID: PMC3400630
View in: PubMed

28.Kaifi JT, Kavuturu S, Judelson D, Staveley-O'Carroll KF. Budd-Chiari syndrome and post-traumatic diaphragmatic hernia. J Thorac Cardiovasc Surg. .143(4):e21-2, 2012. PMID: 22341415
View in: PubMed

29.Avella DM, Li G, Schell TD, Liu D, Zhang SS, Lou X, Berg A, Kimchi ET, Tagaram HR, Yang Q, Shereef S, Garcia LS, Kester M, Isom HC, Rountree CB, Staveley-O'Carroll KF. Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model. Hepatology. .55(1):141-52, 2012. PMID: 21898502 PMCID: PMC3243781
View in: PubMed

30.Jiang Y, DiVittore NA, Kaiser JM, Shanmugavelandy SS, Fritz JL, Heakal Y, Tagaram HR, Cheng H, Cabot MC, Staveley-O'Carroll KF, Tran MA, Fox TE, Barth BM, Kester M. Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer. Cancer Biol Ther. .12(7):574-85, 2011. PMID: 21795855 PMCID: PMC3218384
View in: PubMed

31.Kaifi JT, Toth JW, Gusani NJ, Kimchi ET, Staveley-O'Carroll KF, Belani CP, Reed MF. Multidisciplinary management of malignant pleural effusion. J Surg Oncol. .105(7):731-8, 2011. PMID: 21960207
View in: PubMed

32.Krishnegowda G, Prakasha Gowda AS, Tagaram HR, Carroll KF, Irby RB, Sharma AK, Amin S. Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway. Bioorg Med Chem. .19(20):6006-14, 2011. PMID: 21920762 PMCID: PMC3235409
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33.Avella DM, Podany A, Staveley-O'Carroll KF, Kaifi JT. Laparoscopic repair of post-esophagectomy diaphragmatic hernias using human acellular dermal matrix. Interact Cardiovasc Thorac Surg. .13(2):248-9, 2011. PMID: 21606054
View in: PubMed

34.Kaifi JT, Gusani NJ, Jiang Y, Mackley HB, Dye CE, Mathew A, Kimchi ET, Reed MF, Staveley-O'Carroll KF. Multidisciplinary management of early and locally advanced esophageal cancer. J Clin Gastroenterol. .45(5):391-9, 2011. PMID: 21301357
View in: PubMed

35.Tagaram HR, Divittore NA, Barth BM, Kaiser JM, Avella D, Kimchi ET, Jiang Y, Isom HC, Kester M, Staveley-O'Carroll KF. Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma. Gut. .60(5):695-701, 2010. PMID: 21193455
View in: PubMed

36.Deshaies I, Cherenfant J, Gusani NJ, Jiang Y, Harvey HA, Kimchi ET, Kaifi JT, Staveley-O'Carroll KF. Gastrointestinal stromal tumor (GIST) recurrence following surgery: review of the clinical utility of imatinib treatment. Ther Clin Risk Manag. .6:453-8, 2010. PMID: 20957137 PMCID: PMC2952484
View in: PubMed

37.Kaifi JT, Gusani NJ, Deshaies I, Kimchi ET, Reed MF, Mahraj RP, Staveley-O'Carroll KF. Indications and approach to surgical resection of lung metastases. J Surg Oncol. .102(2):187-95, 2010. PMID: 20648593
View in: PubMed

38.Schubart JR, Wise J, Deshaies I, Kimchi ET, Staveley-O'Carroll KF, Gusani NJ. Quality of life assessment in postoperative patients with upper GI malignancies. J Surg Res. .163(1):40-6, 2010. PMID: 20638690
View in: PubMed

39.Nikfarjam M, Kimchi ET, Gusani NJ, Staveley-O'Carroll KF. Complete surgical resection of giant mucinous hepatic cystadenomas. Am Surg. .76(5):E17-9, 2010. PMID: 21457638
View in: PubMed

40.Avella DM, Kimchi ET, Donahue RN, Tagaram HR, McLaughlin PJ, Zagon IS, Staveley-O'Carroll KF. The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer. Am J Physiol Regul Integr Comp Physiol. .298(2):R459-66, 2009. PMID: 19923357 PMCID: PMC2828179
View in: PubMed

41.Gusani NJ, Schubart JR, Wise J, Farace E, Green MJ, Jiang Y, Kimchi ET, Staveley-O'Carroll KF. Cancer survivorship: a new challenge for surgical and medical oncologists. J Gen Intern Med. .24 Suppl 2:S456-8, 2009. PMID: 19838850 PMCID: PMC2763148
View in: PubMed

42.Kimchi ET, Nikfarjam M, Gusani NJ, Avella DM, Staveley-O'Carroll KF. Combined pancreaticoduodenectomy and extended right hemicolectomy: outcomes and indications. HPB (Oxford). .11(7):559-64, 2009. PMID: 20495707 PMCID: PMC2785950
View in: PubMed

43.Avella D, Garcia LJ, Gusani NJ, Nikfarjam M, Shereef S, Kimchi ET, Staveley-O'Carroll KF. Human acellular dermal matrix: an innovative tool for diaphragmatic reconstruction in patients with large intra-abdominal tumors. Am J Surg. .199(1):e12-6, 2009. PMID: 19837394
View in: PubMed

44.Jiang Y, Kimchi ET, Staveley-O'Carroll KF, Cheng H, Ajani JA. Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer. Cancer. .115(16):3609-17, 2009. PMID: 19526592
View in: PubMed

45.Nikfarjam M, Kimchi ET, Gusani NJ, Shah SM, Sehmbey M, Shereef S, Staveley-O'Carroll KF. A reduction in delayed gastric emptying by classic pancreaticoduodenectomy with an antecolic gastrojejunal anastomosis and a retrogastric omental patch. J Gastrointest Surg. .13(9):1674-82, 2009. PMID: 19548039
View in: PubMed

46.Nikfarjam M, Kimchi ET, Gusani NJ, Avella DM, Shereef S, Staveley-O'Carroll KF. Reduction of surgical site infections by use of pulsatile lavage irrigation after prolonged intra-abdominal surgical procedures. Am J Surg. .198(3):381-6, 2009. PMID: 19344885
View in: PubMed

47.Cherenfant J, Nikfarjam M, Mathew A, Kimchi ET, Staveley-O'Carroll KF. Completion pancreatectomy for treatment of a Clostridium perfringens pancreatic infection. Arch Surg. .144(4):368-70, 2009. PMID: 19380651
View in: PubMed

48.Nikfarjam M, Staveley-O'Carroll KF, Kimchi ET, Hardacre JM. Pancreaticoduodenectomy in patients with a history of Roux-en Y gastric bypass surgery. JOP. .10(2):169-73, 2009. PMID: 19287111
View in: PubMed

49.Nikfarjam M, Sehmbey M, Kimchi ET, Gusani NJ, Shereef S, Avella DM, Staveley-O'Carroll KF. Additional organ resection combined with pancreaticoduodenectomy does not increase postoperative morbidity and mortality. J Gastrointest Surg. .13(5):915-21, 2009. PMID: 19198960
View in: PubMed

50.Choudry HA, Nikfarjam M, Liang JJ, Kimchi ET, Conter R, Gusani NJ, Staveley-O'Carroll KF. Diagnosis and management of retroperitoneal ancient schwannomas. World J Surg Oncol. .7:12, 2009. PMID: 19187535 PMCID: PMC2645401
View in: PubMed

51.Gusani NJ, Jiang Y, Kimchi ET, Staveley-O'Carroll KF, Cheng H, Ajani JA. New pharmacological developments in the treatment of hepatocellular cancer. Drugs. .69(18):2533-40, 2009. PMID: 19943706
View in: PubMed

52.Nikfarjam M, Shereef S, Kimchi ET, Gusani NJ, Jiang Y, Avella DM, Mahraj RP, Staveley-O'Carroll KF. Survival outcomes of patients with colorectal liver metastases following hepatic resection or ablation in the era of effective chemotherapy. Ann Surg Oncol. .16(7):1860-7, 2008. PMID: 19037703
View in: PubMed

53.Ryan CM, Staveley-O'Carroll K, Schell TD. Combined anti-CD40 conditioning and well-timed immunization prolongs CD8+ T cell accumulation and control of established brain tumors. J Immunother. .31(9):906-20, 2008. PMID: 18832997 PMCID: PMC2923041
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54.Garcia LJ, Avella DM, Hartman B, Kimchi E, Staveley-O'Carroll KF. Thoracoabdominal incision: a forgotten tool in the management of complex upper gastrointestinal complications. Am J Surg. .197(2):e28-31, 2008. PMID: 18823615
View in: PubMed

55.Jiang Y, Ming L, Montero AJ, Kimchi E, Nikfarjam M, Staveley-O'Carroll KF. Optimizing imatinib mesylate treatment in gastrointestinal stromal tumors. Gastrointest Cancer Res. .2(5):245-50, 2008. PMID: 19259308 PMCID: PMC2632557
View in: PubMed

56.Avella D, Garcia L, Hartman B, Kimchi E, Staveley-O'Carroll K. Esophageal extension encountered during transhiatal resection of gastric or gastroesophageal tumors: attaining a negative margin. J Gastrointest Surg. .13(2):368-73, 2008. PMID: 18677541
View in: PubMed

57.Nikfarjam M, Gusani NJ, Kimchi ET, Mahraj RP, Staveley-O'Carroll KF. Combined right nephrectomy and pancreaticoduodenectomy. Indications and outcomes. JOP. .9(4):449-55, 2008. PMID: 18648136
View in: PubMed

58.Nikfarjam M, Kimchi E, Shereef S, Gusani NJ, Jiang Y, Liang J, Sehmbey M, Staveley-O'Carroll KF. Surgical outcomes of patients with gastrointestinal stromal tumors in the era of targeted drug therapy. J Gastrointest Surg. .12(11):2023-31, 2008. PMID: 18546049
View in: PubMed

59.Jiang Y, Kimchi ET, Montero AJ, Staveley-O'Carroll KF, Ajani JA. Upper gastrointestinal tumors: current status and future perspectives. Expert Rev Anticancer Ther. .8(6):975-91, 2008. PMID: 18533807
View in: PubMed

60.Liang JJ, Kimchi ET, Staveley-O'Carroll KF, Tan D. Diagnostic and prognostic biomarkers in pancreatic carcinoma. Int J Clin Exp Pathol. .2(1):1-10, 2008. PMID: 18830385 PMCID: PMC2491391
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61.Tagaram HR, Watson AM, Lemonnier FA, Staveley-O'Carroll K, Tevethia SS, Schell TD. An SV40 VP1-derived epitope recognized by CD8+ T cells is naturally processed and presented by HLA-A*0201 and cross-reactive with human polyomavirus determinants. Virology. .376(1):183-90, 2008. PMID: 18402997 PMCID: PMC2464359
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62.Choudry H, Avella D, Garcia L, Han D, Staveley-O'Carroll K, Kimchi E. Use of the left renal vein as a practical conduit in superior mesenteric vein reconstruction. J Surg Res. .146(1):117-20, 2007. PMID: 18028958
View in: PubMed

63.Jiang Y, Montero AJ, Staveley-O'Carroll KF. Adjuvant and preoperative therapy for localized gastric cancer. Gastrointest Cancer Res. .1(4):139-45, 2007. PMID: 19262702 PMCID: PMC2632522
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64.Fulchiero GJ, Salvaggio H, Drabick JJ, Staveley-O'Carroll K, Billingsley EM, Marks JG, Helm KF. Eruptive latent metastatic melanomas after initiation of antitumor necrosis factor therapies. J Am Acad Dermatol. .56(5 Suppl):S65-7, 2007. PMID: 17434043
View in: PubMed

65.Staveley-O'Carroll K, Pan M, Meier A, Han D, McFadden D, Souba W. Developing the young academic surgeon. J Surg Res. .128(2):238-42, 2005. PMID: 16243045
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66.Koniaris LG, Staveley-O'Carroll KF, Zeh HJ, Perez E, Jin XL, Maley WR, Zabari G, Bartlett DL, Khanna A, Franceschi D, Schoeniger LO. Pancreaticoduodenectomy in the presence of superior mesenteric venous obstruction. J Gastrointest Surg. .9(7):915-21, 2005. PMID: 16137584
View in: PubMed

67.Purow B, Staveley-O'Carroll K. Targeting of vaccinia virus using biotin-avidin viral coating and biotinylated antibodies. J Surg Res. .123(1):49-54, 2005. PMID: 15652950
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68.Koniaris LG, Spector SA, Staveley-O'Carroll KF. Complete esophageal diversion: a simplified, easily reversible technique. J Am Coll Surg. .199(6):991-3, 2004. PMID: 15555985
View in: PubMed

69.Staveley-O'Carroll K, Pan M, Meier A, Han D, McFadden D, Souba W. Developing the young academic surgeon. J Surg Res. .118(2):109-13, 2004. PMID: 15099999
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70.Staveley-O'Carroll K, Schell TD, Jimenez M, Mylin LM, Tevethia MJ, Schoenberger SP, Tevethia SS. In vivo ligation of CD40 enhances priming against the endogenous tumor antigen and promotes CD8+ T cell effector function in SV40 T antigen transgenic mice. J Immunol. .171(2):697-707, 2003. PMID: 12847236
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71.Sotomayor EM, Borrello I, Rattis FM, Cuenca AG, Abrams J, Staveley-O'Carroll K, Levitsky HI. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood. .98(4):1070-7, 2001. PMID: 11493453
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72.Staveley-O'Carroll K, Sotomayor E, Montgomery J, Borrello I, Hwang L, Fein S, Pardoll D, Levitsky H. Induction of antigen-specific T cell anergy: An early event in the course of tumor progression. Proc Natl Acad Sci U S A. .95(3):1178-83, 1998. PMID: 9448305 PMCID: PMC18712
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