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Graham W Warren, MD, PhD
Associate Professor of Radiation Oncology
College of Medicine
MUSC

Email: warrengw@musc.edu
 
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Graham W Warren, MD, PhD

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Research Interest:

I am a Board Certified radiation oncologist with a PhD in Toxicology, and my primary research interest is in evaluating the effects of tobacco and tobacco-related products on therapeutic response in cancer patients.  My research approach involves evaluation of how exposures alter tumor biology in preclinical basic laboratory systems, evaluating the epidemiology and health behaviors related to tobacco use and other exposures by cancer patients, the clinical effects of exposure to tobacco on therapeutic response as well as both cancer-related and non-cancer related health outcomes, evaluating the cost-based outcomes of tobacco and cessation on cancer treatment, and policy considerations for standard clinical practice and clinical trials design. 

Positions:
Medical Director, Tobacco Assessment and Cessation Program, Hollings Cancer Center, Medical University of South Carolina
Vice Chair for Research, Department of Radiation Oncology, Medical University of South Carolina

Selected Publications:

1.Tanner NT, Kanodra NM, Gebregziabher M, Payne E, Halbert CH, Warren GW, Egede LE, Silvestri GA. The Association between Smoking Abstinence and Mortality in the National Lung Screening Trial. Am J Respir Crit Care Med. .193(5):534-41, 2016. PMID: 26502000
View in: PubMed

2.Kelemen LE, Warren GW, Koziak JM, Köbel M, Steed H. Smoking may modify the association between neoadjuvant chemotherapy and survival from ovarian cancer. Gynecol Oncol. .140(1):124-30, 2015. PMID: 26549109
View in: PubMed

3.Warren GW, Dibaj S, Hutson A, Cummings KM, Dresler C, Marshall JR. Identifying Targeted Strategies to Improve Smoking Cessation Support for Cancer Patients. J Thorac Oncol. .10(11):1532-7, 2015. PMID: 26317914
View in: PubMed

4.Ostroff JS, Goffin JR, Khuri FR, Warren GW. Perspective on the National Comprehensive Cancer Network's Clinical Practice Guidelines for Smoking Cessation. J Oncol Pract. .12(1):55-8, 2015. PMID: 26374860
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5.Warren GW, Ward KD. Integration of tobacco cessation services into multidisciplinary lung cancer care: rationale, state of the art, and future directions. Transl Lung Cancer Res. .4(4):339-52, 2015. PMID: 26380175 PMCID: PMC4549462
View in: PubMed

6.Alberg AJ, Worley ML, Tooze JA, Hatcher JL, Carpenter MJ, Day TA, Sullivan CA, Warren GW, Sterba KR, Weaver KE. The Validity of Self-reported Recent Smoking in Head and Neck Cancer Surgical Patients. Otolaryngol Head Neck Surg. ., 2015. PMID: 26195573
View in: PubMed

7.Dobson Amato KA, Hyland A, Reed R, Mahoney MC, Marshall J, Giovino G, Bansal-Travers M, Ochs-Balcom HM, Zevon MA, Cummings KM, Nwogu C, Singh AK, Chen H, Warren GW, Reid M. Tobacco Cessation May Improve Lung Cancer Patient Survival. J Thorac Oncol. .10(7):1014-9, 2015. PMID: 26102442 PMCID: PMC4494894
View in: PubMed

8.Cummings KM, Gustafson JW, Sales DJ, Khuri FR, Warren GW. Business as usual is not acceptable. Cancer. .121(17):2864-5, 2015. PMID: 25946698
View in: PubMed

9.Balasubramanian S, Janech MG, Warren GW. Alterations in Salivary Proteome following Single Twenty-Minute Session of Yogic Breathing. Evid Based Complement Alternat Med. .2015:376029, 2015. PMID: 25873979 PMCID: PMC4383272
View in: PubMed

10.Brandon TH, Goniewicz ML, Hanna NH, Hatsukami DK, Herbst RS, Hobin JA, Ostroff JS, Shields PG, Toll BA, Tyne CA, Viswanath K, Warren GW. Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology. J Clin Oncol. .33(8):952-63, 2015. PMID: 25572671
View in: PubMed

11.Brandon TH, Goniewicz ML, Hanna NH, Hatsukami DK, Herbst RS, Hobin JA, Ostroff JS, Shields PG, Toll BA, Tyne CA, Viswanath K, Warren GW. Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology. Clin Cancer Res. .21(3):514-25, 2015. PMID: 25573384
View in: PubMed

12.Warren GW, Sobus S, Gritz ER. The biological and clinical effects of smoking by patients with cancer and strategies to implement evidence-based tobacco cessation support. Lancet Oncol. .15(12):e568-80, 2014. PMID: 25439699
View in: PubMed

13.Sobus SL, Warren GW. The biologic effects of cigarette smoke on cancer cells. Cancer. .120(23):3617-26, 2014. PMID: 25043526
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14.Warren GW. Cigarette smoking and systemic therapy for lung cancer: considering the evidence to improve cancer care. J Thorac Oncol. .9(7):914-6, 2014. PMID: 24926541
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15.Warren GW, Marshall JR, Cummings KM, Singh AK, Reid ME. How can patients who are not referred for treatment receive the best treatment available? Cancer. .120(11):1750-1, 2014. PMID: 24967464
View in: PubMed

16.Cummings KM, Dresler CM, Field JK, Fox J, Gritz ER, Hanna NH, Ikeda N, Jassem J, Mulshine JL, Peters MJ, Yamaguchi NH, Warren G, Zhou C. E-cigarettes and cancer patients. J Thorac Oncol. .9(4):438-41, 2014. PMID: 24736063 PMCID: PMC4040965
View in: PubMed

17.Warren GW, Alberg AJ, Kraft AS, Cummings KM. The 2014 Surgeon General's report: "The health consequences of smoking--50 years of progress": a paradigm shift in cancer care. Cancer. .120(13):1914-6, 2014. PMID: 24687615
View in: PubMed

18.Gritz ER, Toll BA, Warren GW. Tobacco use in the oncology setting: advancing clinical practice and research. Cancer Epidemiol Biomarkers Prev. .23(1):3-9, 2014. PMID: 24420982 PMCID: PMC3893715
View in: PubMed

19.Balogh EP, Dresler C, Fleury ME, Gritz ER, Kean TJ, Myers ML, Nass SJ, Nevidjon B, Toll BA, Warren GW, Herbst RS. Reducing tobacco-related cancer incidence and mortality: summary of an institute of medicine workshop. Oncologist. .19(1):21-31, 2013. PMID: 24304712 PMCID: PMC3903060
View in: PubMed

20.Yang GY, Malik NK, Chandrasekhar R, Ma WW, Flaherty L, Iyer R, Kuvshinoff B, Gibbs J, Wilding G, Warren G, May KS. Change in CA 19-9 levels after chemoradiotherapy predicts survival in patients with locally advanced unresectable pancreatic cancer. J Gastrointest Oncol. .4(4):361-9, 2013. PMID: 24294507 PMCID: PMC3819784
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21.Warren GW, Marshall JR, Cummings KM, Zevon MA, Reed R, Hysert P, Mahoney MC, Hyland AJ, Nwogu C, Demmy T, Dexter E, Kelly M, O'Connor RJ, Houstin T, Jenkins D, Germain P, Singh AK, Epstein J, Dobson Amato KA, Reid ME. Automated tobacco assessment and cessation support for cancer patients. Cancer. .120(4):562-9, 2013. PMID: 24496870 PMCID: PMC4482255
View in: PubMed

22.Jayaprakash V, Merzianu M, Warren GW, Arshad H, Hicks WL, Rigual NR, Sullivan MA, Seshadri M, Marshall JR, Cohan DM, Zhao Y, Singh AK. Survival rates and prognostic factors for infiltrating salivary duct carcinoma: Analysis of 228 cases from the Surveillance, Epidemiology, and End Results database. Head Neck. .36(5):694-701, 2013. PMID: 23606370 PMCID: PMC4524549
View in: PubMed

23.Kukar M, Groman A, Malhotra U, Warren GW, Bogner P, Nwogu CE, Demmy TL, Yendamuri S. Small cell carcinoma of the esophagus: a SEER database analysis. Ann Surg Oncol. .20(13):4239-44, 2013. PMID: 23943025
View in: PubMed

24.Warren GW, Marshall JR, Cummings KM, Toll BA, Gritz ER, Hutson A, Dibaj S, Herbst R, Mulshine JL, Hanna N, Dresler CA. Addressing tobacco use in patients with cancer: a survey of American Society of Clinical Oncology members. J Oncol Pract. .9(5):258-62, 2013. PMID: 23943904 PMCID: PMC3770508
View in: PubMed

25.Platek ME, Myrick E, McCloskey SA, Gupta V, Reid ME, Wilding GE, Cohan D, Arshad H, Rigual NR, Hicks WL, Sullivan M, Warren GW, Singh AK. Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: implications for nutrition integrated treatment pathways. Support Care Cancer. .21(10):2825-33, 2013. PMID: 23743980
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26.Platz TA, Nurkin SJ, Fong MK, Groman A, Flaherty L, Malhotra U, Levea CM, Yendamuri S, Warren GW, Nava HR, May KS. Neoadjuvant chemoradiotherapy for esophageal/gastroesophageal carcinoma. J Gastrointest Oncol. .4(2):137-43, 2013. PMID: 23730509 PMCID: PMC3635186
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27.Yendamuri S, Huang M, Malhotra U, Warren GW, Bogner PN, Nwogu CE, Groman A, Demmy TL. Prognostic implications of signet ring cell histology in esophageal adenocarcinoma. Cancer. .119(17):3156-61, 2013. PMID: 23719932
View in: PubMed

28.Warren GW, Marshall JR, Cummings KM, Toll B, Gritz ER, Hutson A, Dibaj S, Herbst R, Dresler C. Practice patterns and perceptions of thoracic oncology providers on tobacco use and cessation in cancer patients. J Thorac Oncol. .8(5):543-8, 2013. PMID: 23529191 PMCID: PMC3628367
View in: PubMed

29.Toll BA, Brandon TH, Gritz ER, Warren GW, Herbst RS. Assessing tobacco use by cancer patients and facilitating cessation: an American Association for Cancer Research policy statement. Clin Cancer Res. .19(8):1941-8, 2013. PMID: 23570694
View in: PubMed

30.Morales NA, Romano MA, Michael Cummings K, Marshall JR, Hyland AJ, Hutson A, Warren GW. Accuracy of self-reported tobacco use in newly diagnosed cancer patients. Cancer Causes Control. .24(6):1223-30, 2013. PMID: 23553611 PMCID: PMC4477518
View in: PubMed

31.Warren GW, Singh AK. Nicotine and lung cancer. J Carcinog. .12:1, 2013. PMID: 23599683 PMCID: PMC3622363
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32.Warren GW, Cummings KM. Tobacco and lung cancer: risks, trends, and outcomes in patients with cancer. Am Soc Clin Oncol Educ Book. .359-64, 2013. PMID: 23714547
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33.Fung SF, Warren GW, Singh AK. Hope for progress after 40 years of futility? Novel approaches in the treatment of advanced stage III and IV non-small-cell-lung cancer: Stereotactic body radiation therapy, mediastinal lymphadenectomy, and novel systemic therapy. J Carcinog. .11:20, 2012. PMID: 23346013 PMCID: PMC3548357
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34.Malik NK, May KS, Chandrasekhar R, Wee W, Flaherty L, Iyer R, Gibbs J, Kuvshinoff B, Wilding G, Warren G, Yang GY. Treatment of locally advanced unresectable pancreatic cancer: a 10-year experience. J Gastrointest Oncol. .3(4):326-34, 2012. PMID: 23205309 PMCID: PMC3492478
View in: PubMed

35.Warren GW, Reid ME, Cummings KM, Marshall JR. Author's reply to: Smoking at diagnosis and survival in cancer patients. Int J Cancer. .132(4):992, 2012. PMID: 22821409
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36.Idris I, Warren G, Donnelly R. Association between thiazolidinedione treatment and risk of macular edema among patients with type 2 diabetes. Arch Intern Med. .172(13):1005-11, 2012. PMID: 22688528
View in: PubMed

37.Peters EN, Torres E, Toll BA, Cummings KM, Gritz ER, Hyland A, Herbst RS, Marshall JR, Warren GW. Tobacco assessment in actively accruing National Cancer Institute Cooperative Group Program Clinical Trials. J Clin Oncol. .30(23):2869-75, 2012. PMID: 22689794 PMCID: PMC3410402
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38.Schmitt JD, Warren GW, Wang IZ. Potential increase in biological effectiveness from field timing optimization for stereotactic body radiation therapy. Med Phys. .39(6):2956-63, 2012. PMID: 22755680
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39.Platek ME, McCloskey SA, Cruz M, Burke MS, Reid ME, Wilding GE, Rigual NR, Popat SR, Loree TR, Gupta V, Warren GW, Sullivan M, Hicks WL, Singh AK. Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck. Head Neck. .35(5):684-8, 2012. PMID: 22619040
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40.Warren GW, Kasza KA, Reid ME, Cummings KM, Marshall JR. Smoking at diagnosis and survival in cancer patients. Int J Cancer. .132(2):401-10, 2012. PMID: 22539012
View in: PubMed

41.Warren GW, Romano MA, Kudrimoti MR, Randall ME, McGarry RC, Singh AK, Rangnekar VM. Nicotinic modulation of therapeutic response in vitro and in vivo. Int J Cancer. .131(11):2519-27, 2012. PMID: 22447412
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42.Fung-Kee-Fung SD, Hackett R, Hales L, Warren G, Singh AK. A prospective trial of volumetric intensity-modulated arc therapy vs conventional intensity modulated radiation therapy in advanced head and neck cancer. World J Clin Oncol. .3(4):57-62, 2012. PMID: 22553505 PMCID: PMC3341741
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43.Warren GW, Arnold SM, Valentino JP, Gal TJ, Hyland AJ, Singh AK, Rangnekar VM, Cummings KM, Marshall JR, Kudrimoti MR. Accuracy of self-reported tobacco assessments in a head and neck cancer treatment population. Radiother Oncol. .103(1):45-8, 2011. PMID: 22119370 PMCID: PMC3327779
View in: PubMed

44.Martin KL, Gomez J, Nazareth DP, Warren GW, Singh AK. Quantification of incidental mediastinal and hilar irradiation delivered during definitive stereotactic body radiation therapy for peripheral non-small cell lung cancer. Med Dosim. .37(2):182-5, 2011. PMID: 21978531
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45.Gosselin MH, Mahoney MC, Cummings KM, Loree TR, Sullivan M, King BA, Warren G, Hyland A. Evaluation of an intervention to enhance the delivery of smoking cessation services to patients with cancer. J Cancer Educ. .26(3):577-82, 2011. PMID: 21503842
View in: PubMed

46.Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C18-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. .17(18):6097-105, 2011. PMID: 21791630 PMCID: PMC3176980
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47.Platek ME, Merzianu M, Mashtare TL, Popat SR, Rigual NR, Warren GW, Singh AK. Improved survival following surgery and radiation therapy for olfactory neuroblastoma: analysis of the SEER database. Radiat Oncol. .6:41, 2011. PMID: 21518449 PMCID: PMC3098784
View in: PubMed

48.Platek ME, Reid ME, Wilding GE, Jaggernauth W, Rigual NR, Hicks WL, Popat SR, Warren GW, Sullivan M, Thorstad WL, Khan MK, Loree TR, Singh AK. Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy. Head Neck. .33(11):1561-8, 2010. PMID: 21990220 PMCID: PMC4403643
View in: PubMed

49.Walters FS, deFontes CM, Hart H, Warren GW, Chen JS. Lepidopteran-active variable-region sequence imparts coleopteran activity in eCry3.1Ab, an engineered Bacillus thuringiensis hybrid insecticidal protein. Appl Environ Microbiol. .76(10):3082-8, 2010. PMID: 20305020 PMCID: PMC2869115
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50.Yelinek JT, He CY, Warren G. Ultrastructural study of Golgi duplication in Trypanosoma brucei. Traffic. .10(3):300-6, 2009. PMID: 19207482
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51.Jucovic M, Walters FS, Warren GW, Palekar NV, Chen JS. From enzyme to zymogen: engineering Vip2, an ADP-ribosyltransferase from Bacillus cereus, for conditional toxicity. Protein Eng Des Sel. .21(10):631-8, 2008. PMID: 18723852
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52.Satoh A, Warren G. In situ cleavage of the acidic domain from the p115 tether inhibits exocytic transport. Traffic. .9(9):1522-9, 2008. PMID: 18564369 PMCID: PMC3035718
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53.de Graffenried CL, Ho HH, Warren G. Polo-like kinase is required for Golgi and bilobe biogenesis in Trypanosoma brucei. J Cell Biol. .181(3):431-8, 2008. PMID: 18443217 PMCID: PMC2364693
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54.Sun Y, St Clair DK, Fang F, Warren GW, Rangnekar VM, Crooks PA, St Clair WH. The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. Mol Cancer Ther. .6(9):2477-86, 2007. PMID: 17876045 PMCID: PMC2627774
View in: PubMed

55.Shirai K, O'Brien PE. Molecular targets in squamous cell carcinoma of the head and neck. Curr Treat Options Oncol. .8(3):239-51, 2007. PMID: 17962911
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56.Gniadek TJ, Warren G. WatershedCounting3D: a new method for segmenting and counting punctate structures from confocal image data. Traffic. .8(4):339-46, 2007. PMID: 17319897
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57.Grimes KR, Warren GW, Fang F, Xu Y, St Clair WH. Cyclooxygenase-2 inhibitor, nimesulide, improves radiation treatment against non-small cell lung cancer both in vitro and in vivo. Oncol Rep. .16(4):771-6, 2006. PMID: 16969492
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58.Ho HH, He CY, de Graffenried CL, Murrells LJ, Warren G. Ordered assembly of the duplicating Golgi in Trypanosoma brucei. Proc Natl Acad Sci U S A. .103(20):7676-81, 2006. PMID: 16672362 PMCID: PMC1472504
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59.He CY, Pypaert M, Warren G. Golgi duplication in Trypanosoma brucei requires Centrin2. Science. .310(5751):1196-8, 2005. PMID: 16254149
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60.Hartmann J, Hu K, He CY, Pelletier L, Roos DS, Warren G. Golgi and centrosome cycles in Toxoplasma gondii. Mol Biochem Parasitol. .145(1):125-7, 2005. PMID: 16266757
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61.Malsam J, Satoh A, Pelletier L, Warren G. Golgin tethers define subpopulations of COPI vesicles. Science. .307(5712):1095-8, 2005. PMID: 15718469
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62.Satoh A, Malsam J, Warren G. Tethering assays for COPI vesicles mediated by golgins. Methods Enzymol. .404:125-34, 2005. PMID: 16413264
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63.Satoh A, Beard M, Warren G. Preparation and characterization of recombinant golgin tethers. Methods Enzymol. .404:279-96, 2005. PMID: 16413277
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64.Wang Y, Satoh A, Warren G. Mapping the functional domains of the Golgi stacking factor GRASP65. J Biol Chem. .280(6):4921-8, 2004. PMID: 15576368 PMCID: PMC4443495
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65.Ang AL, Taguchi T, Francis S, Fölsch H, Murrells LJ, Pypaert M, Warren G, Mellman I. Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells. J Cell Biol. .167(3):531-43, 2004. PMID: 15534004 PMCID: PMC2172492
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66.He CY, Ho HH, Malsam J, Chalouni C, West CM, Ullu E, Toomre D, Warren G. Golgi duplication in Trypanosoma brucei. J Cell Biol. .165(3):313-21, 2004. PMID: 15138289 PMCID: PMC2172185
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67.Mitra K, Ubarretxena-Belandia I, Taguchi T, Warren G, Engelman DM. Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc Natl Acad Sci U S A. .101(12):4083-8, 2004. PMID: 15016920 PMCID: PMC384699
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68.Axelsson MA, Warren G. Rapid, endoplasmic reticulum-independent diffusion of the mitotic Golgi haze. Mol Biol Cell. .15(4):1843-52, 2004. PMID: 14767069 PMCID: PMC379280
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69.Wang Y, Seemann J, Pypaert M, Shorter J, Warren G. A direct role for GRASP65 as a mitotically regulated Golgi stacking factor. EMBO J. .22(13):3279-90, 2003. PMID: 12839990 PMCID: PMC165642
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70.Taguchi T, Pypaert M, Warren G. Biochemical sub-fractionation of the mammalian Golgi apparatus. Traffic. .4(5):344-52, 2003. PMID: 12713662
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71.Satoh A, Wang Y, Malsam J, Beard MB, Warren G. Golgin-84 is a rab1 binding partner involved in Golgi structure. Traffic. .4(3):153-61, 2003. PMID: 12656988 PMCID: PMC3282115
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72.Meyer HH, Wang Y, Warren G. Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4. EMBO J. .21(21):5645-52, 2002. PMID: 12411482 PMCID: PMC131076
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73.Pelletier L, Stern CA, Pypaert M, Sheff D, Ngô HM, Roper N, He CY, Hu K, Toomre D, Coppens I, Roos DS, Joiner KA, Warren G. Golgi biogenesis in Toxoplasma gondii. Nature. .418(6897):548-52, 2002. PMID: 12152082
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74.Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G. Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. J Cell Biol. .157(1):45-62, 2002. PMID: 11927603 PMCID: PMC2173270
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75.Sheff D, Pelletier L, O'Connell CB, Warren G, Mellman I. Transferrin receptor recycling in the absence of perinuclear recycling endosomes. J Cell Biol. .156(5):797-804, 2002. PMID: 11877458 PMCID: PMC2173326
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76.Seemann J, Pypaert M, Taguchi T, Malsam J, Warren G. Partitioning of the matrix fraction of the Golgi apparatus during mitosis in animal cells. Science. .295(5556):848-51, 2002. PMID: 11823640
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77.Blouin RA, Warren GW. Pharmacokinetic considerations in obesity. J Pharm Sci. .88(1):1-7, 1999. PMID: 9874695
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