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Igor B Roninson, PhD
Professor of Drug Discovery & Biomedical Sciences
College of Pharmacy
USC

Email: roninsoni@sccp.sc.edu
 
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Igor B Roninson, PhD

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Research Interest:

Research in my laboratory comprises the following areas: 1) discovery and characterization of novel targets for cancer treatment through functionbased genomics; 2) developing personalized cancer therapy based on the identification of key molecular targets in individual tumors and matching the target profile with drugs acting on the identified targets; 3) studying mechanisms and consequences of different tumor cell responses to chemotherapy and radiation, in particular senescence and mitotic catastrophe; and 4) studying the mechanisms and developing small-molecule inhibitors of a transcriptional damage response pathway implicated in cancer, Alzheimer’s disease, and viral diseases.

Honors:
Endowed Chair in Translational Cancer Therapeutics, SmartState Center of Economic Excellence

Selected Publications:

1.Porter DC, Farmaki E, Altilia S, Schools GP, West DK, Chen M, Chang BD, Puzyrev AT, Lim CU, Rokow-Kittell R, Friedhoff LT, Papavassiliou AG, Kalurupalle S, Hurteau G, Shi J, Baran PS, Gyorffy B, Wentland MP, Broude EV, Kiaris H, Roninson IB. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. .109(34):13799-804, 2012. PMCID: PMC3427077
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2.Masgras I, Carrera S, de Verdier PJ, Brennan P, Majid A, Makhtar W, Tulchinsky E, Jones GD, Roninson IB, Macip S. Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem. .287(13):9845-54, 2012. PMCID: PMC3322987
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3.Altilia S, Santoro A, Malagoli D, Lanzarini C, Ballesteros Álvarez JA, Galazzo G, Porter DC, Crocco P, Rose G, Passarino G, Roninson IB, Franceschi C, Salvioli S. TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells. Aging (Albany NY). .4(1):28-39, 2012. PMCID: PMC3292903
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4.Shtutman M, Roninson IB. A subunit of coatomer protein complex offers a novel tumor-specific target through a surprising mechanism. Autophagy. .7(12):1551-2, 2011. PMCID: PMC3327618
View in: PubMed

5.Gonzalez RE, Lim CU, Cole K, Bianchini CH, Schools GP, Davis BE, Wada I, Roninson IB, Broude EV. Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells. Cell Cycle. .10(20):3505-14, 2011. PMCID: PMC3356834
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6.Shtutman M, Baig M, Levina E, Hurteau G, Lim CU, Broude E, Nikiforov M, Harkins TT, Carmack CS, Ding Y, Wieland F, Buttyan R, Roninson IB. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ? 2 renders tumor cells dependent on its paralogous gene COPZ1. Proc Natl Acad Sci U S A. .108(30):12449-54, 2011. PMCID: PMC3145676
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7.Zironi I, Gaibani P, Remondini D, Salvioli S, Altilia S, Pierini M, Aicardi G, Verondini E, Milanesi L, Bersani F, Gravina S, Roninson IB, Franceschi C, Castellani G. Molecular remodeling of potassium channels in fibroblasts from centenarians: a marker of longevity? Mech Ageing Dev. .131(11-12):674-81, 2010.
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8.Shtutman M, Maliyekkel A, Shao Y, Carmack CS, Baig M, Warholic N, Cole K, Broude EV, Harkins TT, Ding Y, Roninson IB. Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing. Proc Natl Acad Sci U S A. .107(16):7377-82, 2010. PMCID: PMC2867740
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9.Prencipe M, Fitzpatrick P, Gorman S, Tosetto M, Mosetto M, Klinger R, Furlong F, Harrison M, O'Connor D, Roninson IB, O'Sullivan J, McCann A. Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro. Br J Cancer. .101(11):1900-8, 2009. PMCID: PMC2788249
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10.Gravina S, Lescai F, Hurteau G, Brock GJ, Saramaki A, Salvioli S, Franceschi C, Roninson IB. Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. Aging (Albany NY). .1(5):470-80, 2009. PMCID: PMC2814366
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11.Chan CY, Carmack CS, Long DD, Maliyekkel A, Shao Y, Roninson IB, Ding Y. A structural interpretation of the effect of GC-content on efficiency of RNA interference. BMC Bioinformatics. .10 Suppl 1:S33, 2009. PMCID: PMC2648742
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12.Tapias A, Ciudad CJ, Roninson IB, Noé V. Regulation of Sp1 by cell cycle related proteins. Cell Cycle. .7(18):2856-67, 2008. PMCID: PMC2810142
View in: PubMed

13.Yates KE, Korbel GA, Shtutman M, Roninson IB, DiMaio D. Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell. .7(5):609-21, 2008. PMCID: PMC2745089
View in: PubMed

14.Shao Y, Chan CY, Maliyekkel A, Lawrence CE, Roninson IB, Ding Y. Effect of target secondary structure on RNAi efficiency. RNA. .13(10):1631-40, 2007. PMCID: PMC1986803
View in: PubMed

15.Shtutman M, Levina E, Ohouo P, Baig M, Roninson IB. Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells. Cancer Res. .66(23):11370-80, 2006.
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16.Maliyekkel A, Davis BM, Roninson IB. Cell cycle arrest drastically extends the duration of gene silencing after transient expression of short hairpin RNA. Cell Cycle. .5(20):2390-5, 2006.
View in: PubMed

17.Chen Y, Dokmanovic M, Stein WD, Ardecky RJ, Roninson IB. Agonist and antagonist of retinoic acid receptors cause similar changes in gene expression and induce senescence-like growth arrest in MCF-7 breast carcinoma cells. Cancer Res. .66(17):8749-61, 2006.
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18.Primiano T, Baig M, Maliyekkel A, Chang BD, Fellars S, Sadhu J, Axenovich SA, Holzmayer TA, Roninson IB. Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements. Cancer Cell. .4(1):41-53, 2003.
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19.Chang BD, Watanabe K, Broude EV, Fang J, Poole JC, Kalinichenko TV, Roninson IB. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A. .97(8):4291-6, 2000. PMCID: PMC18232
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20.Levenson VV, Lausch E, Kirschling DJ, Broude EV, Davidovich IA, Libants S, Fedosova V, Roninson IB. A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication. Somat Cell Mol Genet. .25(1):9-26, 1999.
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21.Gudkov AV, Kazarov AR, Thimmapaya R, Axenovich SA, Mazo IA, Roninson IB. Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. .91(9):3744-8, 1994. PMCID: PMC43658
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22.Gudkov AV, Zelnick CR, Kazarov AR, Thimmapaya R, Suttle DP, Beck WT, Roninson IB. Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA. Proc Natl Acad Sci U S A. .90(8):3231-5, 1993. PMCID: PMC46273
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23.Holzmayer TA, Pestov DG, Roninson IB. Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments. Nucleic Acids Res. .20(4):711-7, 1992. PMCID: PMC312009
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24.Noonan KE, Roninson IB. mRNA phenotyping by enzymatic amplification of randomly primed cDNA. Nucleic Acids Res. .16(21):10366, 1988. PMCID: PMC338868
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25.Fukumoto M, Shevrin DH, Roninson IB. Analysis of gene amplification in human tumor cell lines. Proc Natl Acad Sci U S A. .85(18):6846-50, 1988. PMCID: PMC282075
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26.Roninson IB, Abelson HT, Housman DE, Howell N, Varshavsky A. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature. .309(5969):626-8, 1984.
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27.Roninson IB. Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gels. Nucleic Acids Res. .11(16):5413-31, 1983. PMCID: PMC326287
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