Research Interest:
Immune regulation by the innate immune system in the context of cancer, infection and autoimmune disease; Stem cell biology
Positions: Leader, Cancer Immunology Program, Hollings Cancer Center, Medical University of South Carolina
Selected Publications:
| 1. | Liu B, Staron M, Hong F, Wu BX, Sun S, Morales C, Crosson CE, Tomlinson S, Kim I, Wu D, Li Z. Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Proc Natl Acad Sci U S A. .110(17):6877-82, 2013. PMCID: PMC3637754
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| | 2. | Rachidi SM, Qin T, Sun S, Zheng WJ, Li Z. Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer marker. PLoS One. .8(3):e57911, 2013. PMCID: PMC3607594
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| | 3. | An N, Lin YW, Mahajan S, Kellner JN, Wang Y, Li Z, Kraft AS, Kang Y. Pim1 serine/threonine Kinase Regulates the Number and Functions of Murine Hematopoietic Stem Cells. Stem Cells. ., 2013.
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| | 4. | Pandey JP, Li Z. The forgotten tale of immunoglobulin allotypes in cancer risk and treatment. Exp Hematol Oncol. .2(1):6, 2013. PMCID: PMC3598368
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| | 5. | Liu B, Staron M, Li Z. Murine but not human basophil undergoes cell-specific proteolysis of a major endoplasmic reticulum chaperone. PLoS One. .7(6):e39442, 2012. PMCID: PMC3377640
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| | 6. | Maitra U, Deng H, Glaros T, Baker B, Capelluto DG, Li Z, Li L. Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide. J Immunol. .189(2):1014-23, 2012. PMCID: PMC3392521
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| | 7. | Barton ER, Park S, James JK, Makarewich CA, Philippou A, Eletto D, Lei H, Brisson B, Ostrovsky O, Li Z, Argon Y. Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. FASEB J. .26(9):3691-702, 2012. PMCID: PMC3425820
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| | 8. | Wu S, Dole K, Hong F, Noman AS, Issacs J, Liu B, Li Z. Chaperone gp96-independent inhibition of endotoxin response by chaperone-based peptide inhibitors. J Biol Chem. .287(24):19896-903, 2012. PMCID: PMC3370174
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| | 9. | Li Z, Hsueh CT, Liu D. Publish, not perish: Introducing Experimental Hematology & Oncology. Exp Hematol Oncol. .1(1):1, 2012. PMCID: PMC3506992
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| | 10. | Wu S, Hong F, Gewirth D, Guo B, Liu B, Li Z. The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain. J Biol Chem. .287(9):6735-42, 2012. PMCID: PMC3307303
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| | 11. | Staron M, Wu S, Hong F, Stojanovic A, Du X, Bona R, Liu B, Li Z. Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Blood. .117(26):7136-44, 2011. PMCID: PMC3143555
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| | 12. | Li X, Zhang K, Li Z. Unfolded protein response in cancer: the physician's perspective. J Hematol Oncol. .4:8, 2011. PMCID: PMC3060154
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| | 13. | Audouard C, Le Masson F, Charry C, Li Z, Christians ES. Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes. PLoS One. .6(2):e17109, 2011. PMCID: PMC3039677
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| | 14. | Usmani SZ, Bona RD, Chiosis G, Li Z. The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1. J Hematol Oncol. .3:40, 2010. PMCID: PMC2974653
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| | 15. | Liu B, Yang Y, Qiu Z, Staron M, Hong F, Li Y, Wu S, Li Y, Hao B, Bona R, Han D, Li Z. Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun. .1:79, 2010. PMCID: PMC2982182
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| | 16. | Han JM, Kwon NH, Lee JY, Jeong SJ, Jung HJ, Kim HR, Li Z, Kim S. Identification of gp96 as a novel target for treatment of autoimmune disease in mice. PLoS One. .5(3):e9792, 2010. PMCID: PMC2843739
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| | 17. | Liu B, Nash J, Runowicz C, Swede H, Stevens R, Li Z. Ovarian cancer immunotherapy: opportunities, progresses and challenges. J Hematol Oncol. .3:7, 2010. PMCID: PMC2831814
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| | 18. | McAleer JP, Liu B, Li Z, Ngoi SM, Dai J, Oft M, Vella AT. Potent intestinal Th17 priming through peripheral lipopolysaccharide-based immunization. J Leukoc Biol. .88(1):21-31, 2010. PMCID: PMC2892526
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| | 19. | Li Y, Zeng H, Xu RH, Liu B, Li Z. Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer. Stem Cells. .27(12):3103-11, 2009.
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| | 20. | Staron M, Yang Y, Liu B, Li J, Shen Y, Zúñiga-Pflücker JC, Aguila HL, Goldschneider I, Li Z. gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood. .115(12):2380-90, 2009. PMCID: PMC2845896
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| | 21. | Morales C, Wu S, Yang Y, Hao B, Li Z. Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins. J Immunol. .183(8):5121-8, 2009. PMCID: PMC2856694
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| | 22. | Usmani SZ, Bona R, Li Z. 17 AAG for HSP90 inhibition in cancer--from bench to bedside. Curr Mol Med. .9(5):654-64, 2009.
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| | 23. | Dai J, Liu B, Li Z. Regulatory T cells and Toll-like receptors: what is the missing link? Int Immunopharmacol. .9(5):528-33, 2009. PMCID: PMC2856690
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| | 24. | Goldstein MG, Li Z. Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis. J Hematol Oncol. .2:5, 2009. PMCID: PMC2644312
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| | 25. | Qiao Y, Liu B, Li Z. Activation of NK cells by extracellular heat shock protein 70 through induction of NKG2D ligands on dendritic cells. Cancer Immun. .8:12, 2008. PMCID: PMC2935777
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| | 26. | Dhodapkar MV, Dhodapkar KM, Li Z. Role of chaperones and FcgammaR in immunogenic death. Curr Opin Immunol. .20(5):512-7, 2008. PMCID: PMC3224819
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| | 27. | Liu B, Li Z. Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin. Blood. .112(4):1223-30, 2008. PMCID: PMC2515121
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| | 28. | Gorusu M, Benn P, Li Z, Fang M. On the genesis and prognosis of variant translocations in chronic myeloid leukemia. Cancer Genet Cytogenet. .173(2):97-106, 2007.
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| | 29. | Dai J, Liu B, Cua DJ, Li Z. Essential roles of IL-12 and dendritic cells but not IL-23 and macrophages in lupus-like diseases initiated by cell surface HSP gp96. Eur J Immunol. .37(3):706-15, 2007.
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| | 30. | Dai J, Liu B, Ngoi SM, Sun S, Vella AT, Li Z. TLR4 hyperresponsiveness via cell surface expression of heat shock protein gp96 potentiates suppressive function of regulatory T cells. J Immunol. .178(5):3219-25, 2007.
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| | 31. | Yang Y, Liu B, Dai J, Srivastava PK, Zammit DJ, Lefrançois L, Li Z. Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity. .26(2):215-26, 2007. PMCID: PMC2847270
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| | 32. | Liu B, Yang Y, Dai J, Medzhitov R, Freudenberg MA, Zhang PL, Li Z. TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol. .177(10):6880-8, 2006.
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| | 33. | Yang Y, Li Z. Roles of heat shock protein gp96 in the ER quality control: redundant or unique function? Mol Cells. .20(2):173-82, 2005.
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| | 34. | Pritchard MT, Li Z, Repasky EA. Nitric oxide production is regulated by fever-range thermal stimulation of murine macrophages. J Leukoc Biol. .78(3):630-8, 2005.
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| | 35. | Li Z, Qiao Y, Liu B, Laska EJ, Chakravarthi P, Kulko JM, Bona RD, Fang M, Hegde U, Moyo V, Tannenbaum SH, Ménoret A, Gaffney J, Glynn L, Runowicz CD, Srivastava PK. Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia. Clin Cancer Res. .11(12):4460-8, 2005.
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| | 36. | Zheng H, Li Z. Cutting edge: cross-presentation of cell-associated antigens to MHC class I molecule is regulated by a major transcription factor for heat shock proteins. J Immunol. .173(10):5929-33, 2004.
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| | 37. | DeFillipo AM, Dai J, Li Z. Heat shock-induced dendritic cell maturation is coupled by transient aggregation of ubiquitinated proteins independently of heat shock factor 1 or inducible heat shock protein 70. Mol Immunol. .41(8):785-92, 2004.
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| | 38. | Liu B, Dai J, Zheng H, Stoilova D, Sun S, Li Z. Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases. Proc Natl Acad Sci U S A. .100(26):15824-9, 2003. PMCID: PMC307652
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| | 39. | Millar DG, Garza KM, Odermatt B, Elford AR, Ono N, Li Z, Ohashi PS. Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Nat Med. .9(12):1469-76, 2003.
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| | 40. | Zheng H, Benjamin IJ, Basu S, Li Z. Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response. Eur J Immunol. .33(6):1754-62, 2003.
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| | 41. | Dai J, Liu B, Caudill MM, Zheng H, Qiao Y, Podack ER, Li Z. Cell surface expression of heat shock protein gp96 enhances cross-presentation of cellular antigens and the generation of tumor-specific T cell memory. Cancer Immun. .3:1, 2003.
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| | 42. | Liu B, DeFilippo AM, Li Z. Overcoming immune tolerance to cancer by heat shock protein vaccines. Mol Cancer Ther. .1(12):1147-51, 2002.
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| | 43. | Li Z, Dai J, Zheng H, Liu B, Caudill M. An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response. Front Biosci. .7:d731-51, 2002.
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| | 44. | Zheng H, Dai J, Stoilova D, Li Z. Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity. J Immunol. .167(12):6731-5, 2001.
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| | 45. | Blachere NE, Li Z, Chandawarkar RY, Suto R, Jaikaria NS, Basu S, Udono H, Srivastava PK. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med. .186(8):1315-22, 1997. PMCID: PMC2199095
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| | 46. | Srivastava PK, Udono H, Blachere NE, Li Z. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics. .39(2):93-8, 1994.
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| | 47. | Li Z, Srivastava PK. Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation. EMBO J. .12(8):3143-51, 1993. PMCID: PMC413580
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