Research Interest:
Thermal tumor ablation, image-guided thermal cancer therapies, radiofrequency ablation, microwave ablation, HIFU -drug delivery systems -image-guided therapies
Selected Publications:
| 1. | Li L, Ten Hagen TL, Hossann M, Süss R, van Rhoon GC, Eggermont AM, Haemmerich D, Koning GA. Mild hyperthermia triggered doxorubicin release from optimized stealth thermosensitive liposomes improves intratumoral drug delivery and efficacy. J Control Release. .168(2):142-150, 2013.
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| | 2. | Li L, Ten Hagen TL, Bolkestein M, Gasselhuber A, Yatvin J, van Rhoon GC, Eggermont AM, Haemmerich D, Koning GA. Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia. J Control Release. .167(2):130-137, 2013.
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| | 3. | Gasselhuber A, Dreher MR, Rattay F, Wood BJ, Haemmerich D. Comparison of conventional chemotherapy, stealth liposomes and temperature-sensitive liposomes in a mathematical model. PLoS One. .7(10):e47453, 2012. PMCID: PMC3474827
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| | 4. | Thaker AA, Razjouyan F, Woods DL, Haemmerich D, Sekhar K, Wood BJ, Dreher MR. Combination therapy of radiofrequency ablation and bevacizumab monitored with power Doppler ultrasound in a murine model of hepatocellular carcinoma. Int J Hyperthermia. .28(8):766-75, 2012.
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| | 5. | Gasselhuber A, Dreher MR, Partanen A, Yarmolenko PS, Woods D, Wood BJ, Haemmerich D. Targeted drug delivery by high intensity focused ultrasound mediated hyperthermia combined with temperature-sensitive liposomes: computational modelling and preliminary in vivovalidation. Int J Hyperthermia. .28(4):337-48, 2012.
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| | 6. | Partanen A, Yarmolenko PS, Viitala A, Appanaboyina S, Haemmerich D, Ranjan A, Jacobs G, Woods D, Enholm J, Wood BJ, Dreher MR. Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery. Int J Hyperthermia. .28(4):320-36, 2012.
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| | 7. | Kong X, Chbat N, Haemmerich D, Kroll M, Panescu D. Innovative engineering solutions. “Lessons learned from medical systems development“ workshop--32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). IEEE Pulse. .2(1):34-8, 2011.
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| | 8. | Haemmerich D, Schutt DJ. RF ablation at low frequencies for targeted tumor heating: in vitro and computational modeling results. IEEE Trans Biomed Eng. .58(2):404-10, 2010. PMCID: PMC3108076
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| | 9. | Sun H, Haemmerich D, Rahko PS, Webster JG. Estimating the probability that the Taser directly causes human ventricular fibrillation. J Med Eng Technol. .34(3):178-91, 2010.
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| | 10. | Strigel RM, Schutt DJ, Webster JG, Mahvi DM, Haemmerich D. An Electrode Array for Limiting Blood Loss During Liver Resection: Optimization via Mathematical Modeling. Open Biomed Eng J. .4:39-46, 2010. PMCID: PMC2840609
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| | 11. | Haemmerich D, Berjano EJ. Current trends in mathematical modeling of high-temperature thermal therapies. Open Biomed Eng J. .4:1-2, 2010. PMCID: PMC2841366
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| | 12. | Haemmerich D. Biophysics of radiofrequency ablation. Crit Rev Biomed Eng. .38(1):53-63, 2010.
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| | 13. | Haemmerich D. Mathematical modeling of impedance controlled radiofrequency tumor ablation and ex-vivo validation. Conf Proc IEEE Eng Med Biol Soc. .2010:1605-8, 2010. PMCID: PMC3108073
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| | 14. | Gasselhuber A, Dreher MR, Negussie A, Wood BJ, Rattay F, Haemmerich D. Mathematical spatio-temporal model of drug delivery from low temperature sensitive liposomes during radiofrequency tumour ablation. Int J Hyperthermia. .26(5):499-513, 2010. PMCID: PMC2958178
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| | 15. | Schutt DJ, Swindle MM, Helke KL, Bastarrika G, Schwarz F, Haemmerich D. Sequential activation of ground pads reduces skin heating during radiofrequency tumor ablation: in vivo porcine results. IEEE Trans Biomed Eng. .57(3):746-53, 2009. PMCID: PMC3108072
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| | 16. | Haemmerich D, Schutt DJ, Wright AW, Webster JG, Mahvi DM. Electrical conductivity measurement of excised human metastatic liver tumours before and after thermal ablation. Physiol Meas. .30(5):459-66, 2009. PMCID: PMC2730770
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| | 17. | Schutt D, Berjano EJ, Haemmerich D. Effect of electrode thermal conductivity in cardiac radiofrequency catheter ablation: a computational modeling study. Int J Hyperthermia. .25(2):99-107, 2009.
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| | 18. | Dos Santos I, Haemmerich D, Schutt D, da Rocha AF, Menezes LR. Probabilistic finite element analysis of radiofrequency liver ablation using the unscented transform. Phys Med Biol. .54(3):627-40, 2009. PMCID: PMC2730782
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| | 19. | Schutt DJ, Swindle MM, Bastarrika GA, Haemmerich D. Sequential activation of ground pads reduces skin heating during radiofrequency ablation: initial in vivo porcine results. Conf Proc IEEE Eng Med Biol Soc. .2009:4287-90, 2009. PMCID: PMC2791912
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| | 20. | dos Santos I, Correia D, Soares AJ, Góes JA, da Rocha AF, Schutt D, Haemmerich D. A surgical device for radiofrequency ablation of large liver tumors. Physiol Meas. .29(10):N59-70, 2008.
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| | 21. | Schutt DJ, Haemmerich D. Effects of variation in perfusion rates and of perfusion models in computational models of radio frequency tumor ablation. Med Phys. .35(8):3462-70, 2008. PMCID: PMC2673648
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| | 22. | dos Santos I, Haemmerich D, Pinheiro Cda S, da Rocha AF. Effect of variable heat transfer coefficient on tissue temperature next to a large vessel during radiofrequency tumor ablation. Biomed Eng Online. .7:21, 2008. PMCID: PMC2500024
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| | 23. | Schutt DJ, Haemmerich D. Sequential activation of a segmented ground pad reduces skin heating during radiofrequency tumor ablation: optimization via computational models. IEEE Trans Biomed Eng. .55(7):1881-9, 2008. PMCID: PMC2711506
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| | 24. | Pilcher TA, Saul JP, Hlavacek AM, Haemmerich D. Contrasting effects of convective flow on catheter ablation lesion size: cryo versus radiofrequency energy. Pacing Clin Electrophysiol. .31(3):300-7, 2008.
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| | 25. | Haemmerich D, Schutt DJ. Sequential activation of multiple grounding pads reduces skin heating during radiofrequency tumor ablation. Int J Hyperthermia. .23(7):555-66, 2007. PMCID: PMC2729586
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| | 26. | O'Rourke AP, Haemmerich D, Prakash P, Converse MC, Mahvi DM, Webster JG. Current status of liver tumor ablation devices. Expert Rev Med Devices. .4(4):523-37, 2007.
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| | 27. | Schutt DJ, O'Rourke AP, Will JA, Webster JG, Mahvi DM, Haemmerich D. An electrode array that minimizes blood loss for radiofrequency-assisted hepatic resection. Med Eng Phys. .30(4):454-9, 2007. PMCID: PMC2446607
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| | 28. | Meredith K, Haemmerich D, Qi C, Mahvi D. Hepatic resection but not radiofrequency ablation results in tumor growth and increased growth factor expression. Ann Surg. .245(5):771-6, 2007. PMCID: PMC1877067
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| | 29. | Wood BJ, Locklin JK, Viswanathan A, Kruecker J, Haemmerich D, Cebral J, Sofer A, Cheng R, McCreedy E, Cleary K, McAuliffe MJ, Glossop N, Yanof J. Technologies for guidance of radiofrequency ablation in the multimodality interventional suite of the future. J Vasc Interv Radiol. .18(1 Pt 1):9-24, 2007. PMCID: PMC2555973
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| | 30. | Pilcher TA, Sanford AL, Saul JP, Haemmerich D. Convective cooling effect on cooled-tip catheter compared to large-tip catheter radiofrequency ablation. Pacing Clin Electrophysiol. .29(12):1368-74, 2006.
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| | 31. | Haemmerich D, Wood BJ. Hepatic radiofrequency ablation at low frequencies preferentially heats tumour tissue. Int J Hyperthermia. .22(7):563-74, 2006. PMCID: PMC2408946
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| | 32. | Laeseke PF, Sampson LA, Haemmerich D, Brace CL, Fine JP, Frey TM, Winter TC, Lee FT. Multiple-electrode radiofrequency ablation creates confluent areas of necrosis: in vivo porcine liver results. Radiology. .241(1):116-24, 2006.
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| | 33. | Schramm W, Yang D, Haemmerich D. Contribution of direct heating, thermal conduction and perfusion during radiofrequency and microwave ablation. Conf Proc IEEE Eng Med Biol Soc. .1:5013-6, 2006.
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| | 34. | Laeseke PF, Sampson LA, Haemmerich D, Brace CL, Fine JP, Frey TM, Winter TC, Lee FT. Multiple-electrode radiofrequency ablation: simultaneous production of separate zones of coagulation in an in vivo porcine liver model. J Vasc Interv Radiol. .16(12):1727-35, 2005.
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| | 35. | Haemmerich D, Laeseke PF. Thermal tumour ablation: devices, clinical applications and future directions. Int J Hyperthermia. .21(8):755-60, 2005.
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| | 36. | Pareek G, Wilkinson ER, Schutt D, Will JA, Warner TF, Haemmerich D, Mahvi D, Nakada SY. Haemostatic partial nephrectomy using bipolar radiofrequency ablation. BJU Int. .96(7):1101-4, 2005.
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| | 37. | da Rocha AF, dos Santos I, Nascimento FA, Melo MD, Haemmerich D, Valvano JW. Effects of the time response of the temperature sensor on thermodilution measurements. Physiol Meas. .26(6):885-901, 2005.
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| | 38. | Haemmerich D, Webster JG. Automatic control of finite element models for temperature-controlled radiofrequency ablation. Biomed Eng Online. .4(1):42, 2005. PMCID: PMC1180460
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| | 39. | Haemmerich D, dos Santos I, Schutt DJ, Webster JG, Mahvi DM. In vitro measurements of temperature-dependent specific heat of liver tissue. Med Eng Phys. .28(2):194-7, 2005.
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| | 40. | Shah J, dos Santos I, Haemmerich D, Valvano JW. Instrument to measure the heat convection coefficient on the endothelial surface of arteries and veins. Med Biol Eng Comput. .43(4):522-7, 2005.
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| | 41. | Haemmerich D, Lee FT. Multiple applicator approaches for radiofrequency and microwave ablation. Int J Hyperthermia. .21(2):93-106, 2005.
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| | 42. | Haemmerich D, Schutt DJ, dos Santos I, Webster JG, Mahvi DM. Measurement of temperature-dependent specific heat of biological tissues. Physiol Meas. .26(1):59-67, 2005.
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| | 43. | Haemmerich D, Lee FT, Schutt DJ, Sampson LA, Webster JG, Fine JP, Mahvi DM. Large-volume radiofrequency ablation of ex vivo bovine liver with multiple cooled cluster electrodes. Radiology. .234(2):563-8, 2004.
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| | 44. | Lai YC, Choy YB, Haemmerich D, Vorperian VR, Webster JG. Lesion size estimator of cardiac radiofrequency ablation at different common locations with different tip temperatures. IEEE Trans Biomed Eng. .51(10):1859-64, 2004.
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| | 45. | Consiglieri L, dos Santos I, Haemmerich D. Theoretical analysis of the heat convection coefficient in large vessels and the significance for thermal ablative therapies. Phys Med Biol. .48(24):4125-34, 2003.
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| | 46. | Nakada SY, Jerde TJ, Warner TF, Wright AS, Haemmerich D, Mahvi DM, Lee FT. Bipolar radiofrequency ablation of the kidney: comparison with monopolar radiofrequency ablation. J Endourol. .17(10):927-33, 2003.
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| | 47. | Lee FT, Haemmerich D, Wright AS, Mahvi DM, Sampson LA, Webster JG. Multiple probe radiofrequency ablation: pilot study in an animal model. J Vasc Interv Radiol. .14(11):1437-42, 2003.
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| | 48. | Haemmerich D, Staelin ST, Tsai JZ, Tungjitkusolmun S, Mahvi DM, Webster JG. In vivo electrical conductivity of hepatic tumours. Physiol Meas. .24(2):251-60, 2003.
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| | 49. | Haemmerich D, Wright AW, Mahvi DM, Lee FT, Webster JG. Hepatic bipolar radiofrequency ablation creates coagulation zones close to blood vessels: a finite element study. Med Biol Eng Comput. .41(3):317-23, 2003.
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| | 50. | Haemmerich D, Chachati L, Wright AS, Mahvi DM, Lee FT, Webster JG. Hepatic radiofrequency ablation with internally cooled probes: effect of coolant temperature on lesion size. IEEE Trans Biomed Eng. .50(4):493-500, 2003.
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| | 51. | Wright AS, Mahvi DM, Haemmerich DG, Lee FT. Minimally invasive approaches in management of hepatic tumors. Surg Technol Int. .11:144-53, 2003.
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| | 52. | Haemmerich D, Tungjitkusolmun S, Staelin ST, Lee FT, Mahvi DM, Webster JG. Finite-element analysis of hepatic multiple probe radio-frequency ablation. IEEE Trans Biomed Eng. .49(8):836-42, 2002.
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| | 53. | Tsai JZ, Will JA, Hubbard-Van Stelle S, Cao H, Tungjitkusolmun S, Choy YB, Haemmerich D, Vorperian VR, Webster JG. In-vivo measurement of swine myocardial resistivity. IEEE Trans Biomed Eng. .49(5):472-83, 2002.
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| | 54. | Tsai JZ, Will JA, Hubbard-Van Stelle S, Cao H, Tungjitkusolmun S, Choy YB, Haemmerich D, Vorperian VR, Webster JG. Error analysis of tissue resistivity measurement. IEEE Trans Biomed Eng. .49(5):484-94, 2002.
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| | 55. | Haemmerich D, Ozkan R, Tungjitkusolmun S, Tsai JZ, Mahvi DM, Staelin ST, Webster JG. Changes in electrical resistivity of swine liver after occlusion and postmortem. Med Biol Eng Comput. .40(1):29-33, 2002.
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| | 56. | Tungjitkusolmun S, Staelin ST, Haemmerich D, Tsai JZ, Webster JG, Lee FT, Mahvi DM, Vorperian VR. Three-Dimensional finite-element analyses for radio-frequency hepatic tumor ablation. IEEE Trans Biomed Eng. .49(1):3-9, 2002.
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| | 57. | Tungjitkusolmun S, Haemmerich D, Cao H, Tsai JZ, Choy YB, Vorperian VR, Webster JG. Modeling bipolar phase-shifted multielectrode catheter ablation. IEEE Trans Biomed Eng. .49(1):10-7, 2002.
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| | 58. | Haemmerich D, Staelin ST, Tungjitkusolmun S, Lee FT, Mahvi DM, Webster JG. Hepatic bipolar radio-frequency ablation between separated multiprong electrodes. IEEE Trans Biomed Eng. .48(10):1145-52, 2001.
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| | 59. | Cao H, Vorperian VR, Tungjitkusolmun S, Tsai JZ, Haemmerich D, Choy YB, Webster JG. Flow effect on lesion formation in RF cardiac catheter ablation. IEEE Trans Biomed Eng. .48(4):425-33, 2001.
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