Research Interest:
My research interests concern the cellular and molecular mechanisms underlying hypoxic and toxic injury to liver and heart cells and organs stored for transplantation surgery. In particular, my laboratory is applying new techniques of laser scanning confocal and multiphoton microscopy to characterize the physiology of single living cells, including the assessment of ion homeostasis, mitochondrial function, electrical potentials, oxygen and nitrogen free radical formation, membrane permeability and other biochemical parameters during the pathogenesis of lethal cell injury.
Positions: Director, Center for Cell Death, Injury and Regeneration, Medical University of South Carolina
Selected Publications:
| 1. | Maldonado EN, Sheldon KL, Dehart DN, Patnaik J, Manevich Y, Townsend DM, Berzukov SM, Rostovtseva TK, Lemasters JJ. Voltage dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J Biol Chem. ., 2013.
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| | 2. | Schemmer P, Lemasters JJ, Clavien PA. Ischemia/Reperfusion injury in liver surgery and transplantation. HPB Surg. .2012:453295, 2012. PMCID: PMC3546476
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| | 3. | He S, Rehman H, Shi Y, Krishnasamy Y, Lemasters JJ, Schnellmann RG, Zhong Z. Suramin Decreases Injury and Improves Regeneration of Ethanol-Induced Steatotic Partial Liver Grafts. J Pharmacol Exp Ther. ., 2012.
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| | 4. | Hung HI, Schwartz JM, Maldonado EN, Lemasters JJ, Nieminen AL. Mitoferrin2-Dependent Mitochondrial Iron Uptake Sensitizes Human Head and Neck Squamous Carcinoma Cells to Photodynamic Therapy. J Biol Chem. ., 2012.
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| | 5. | Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol. .8(10):831-8, 2012.
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| | 6. | Woolbright BL, Ramachandran A, McGill MR, Yan HM, Bajt ML, Sharpe MR, Lemasters JJ, Jaeschke H. Lysosomal Instability and Cathepsin B Release during Acetaminophen Hepatotoxicity. Basic Clin Pharmacol Toxicol. .111(6):417-25, 2012. PMCID: PMC3501614
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| | 7. | Liu Q, Rehman H, Shi Y, Krishnasamy Y, Lemasters JJ, Smith CD, Zhong Z. Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One. .7(7):e41834, 2012. PMCID: PMC3405047
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| | 8. | Currin RT, Peng XX, Lemasters JJ. Ischemic preconditioning of rat livers from non-heart-beating donors decreases parenchymal cell killing and increases graft survival after transplantation. HPB Surg. .2012:236406, 2012. PMCID: PMC3408666
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| | 9. | Czerny C, Theruvath TP, Maldonado EN, Lehnert M, Marzi I, Zhong Z, Lemasters JJ. C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation. HPB Surg. .2012:641982, 2012. PMCID: PMC3390051
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| | 10. | Theruvath TP, Ramshesh VK, Zhong Z, Currin RT, Karrasch T, Lemasters JJ. Icam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation. HPB Surg. .2012:480893, 2012. PMCID: PMC3385666
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| | 11. | Liu Q, Rehman H, Krishnasamy Y, Haque K, Schnellmann RG, Lemasters JJ, Zhong Z. Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation. Am J Transplant. .12(8):2052-61, 2012. PMCID: PMC3409348
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| | 12. | Maldonado EN, Lemasters JJ. Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells. J Pharmacol Exp Ther. .342(3):637-41, 2012. PMCID: PMC3422523
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| | 13. | Czerny C, Kholmukhamedov A, Theruvath TP, Maldonado EN, Ramshesh VK, Lehnert M, Marzi I, Zhong Z, Lemasters JJ. Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice. HPB Surg. .2012:259512, 2012. PMCID: PMC3375163
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| | 14. | Liu Q, Rehman H, Harley RA, Lemasters JJ, Zhong Z. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811. HPB Surg. .2012:270372, 2012. PMCID: PMC3364580
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| | 15. | Liu Q, Rehman H, Krishnasamy Y, Ramshesh VK, Theruvath TP, Chavin KD, Schnellmann RG, Lemasters JJ, Zhong Z. Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers. Free Radic Biol Med. .53(2):250-9, 2012. PMCID: PMC3392495
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| | 16. | Dolganiuc A, Thomes PG, Ding WX, Lemasters JJ, Donohue TM. Autophagy in alcohol-induced liver diseases. Alcohol Clin Exp Res. .36(8):1301-8, 2012.
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| | 17. | Saggu S, Hung HI, Quiogue G, Lemasters JJ, Nieminen AL. Lysosomal signaling enhances mitochondria-mediated photodynamic therapy in A431 cancer cells: role of iron. Photochem Photobiol. .88(2):461-8, 2012.
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| | 18. | Kim JS, Wang JH, Lemasters JJ. Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species. Am J Physiol Gastrointest Liver Physiol. .302(7):G723-31, 2012. PMCID: PMC3330780
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| | 19. | Holmuhamedov EL, Czerny C, Beeson CC, Lemasters JJ. Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde. J Biol Chem. .287(10):7692-700, 2012. PMCID: PMC3293599
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| | 20. | Ramshesh VK, Lemasters JJ. Imaging of mitochondrial pH using SNARF-1. Methods Mol Biol. .810:243-8, 2012.
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| | 21. | Lemasters JJ, Holmuhamedov EL, Czerny C, Zhong Z, Maldonado EN. Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect. Biochim Biophys Acta. .1818(6):1536-44, 2011. PMCID: PMC3422743
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| | 22. | Sheldon KL, Maldonado EN, Lemasters JJ, Rostovtseva TK, Bezrukov SM. Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS One. .6(10):e25539, 2011. PMCID: PMC3192757
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| | 23. | Koch DG, Bogatkevich G, Ramshesh V, Lemasters JJ, Uflacker R, Reuben A. Elevated levels of endothelin-1 in hepatic venous blood are associated with intrapulmonary vasodilatation in humans. Dig Dis Sci. .57(2):516-23, 2011.
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| | 24. | Shi Y, Rehman H, Ramshesh VK, Schwartz J, Liu Q, Krishnasamy Y, Zhang X, Lemasters JJ, Smith CD, Zhong Z. Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. J Hepatol. .56(1):137-45, 2011. PMCID: PMC3220779
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| | 25. | Bajt ML, Ramachandran A, Yan HM, Lebofsky M, Farhood A, Lemasters JJ, Jaeschke H. Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. Toxicol Sci. .122(2):598-605, 2011. PMCID: PMC3155087
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| | 26. | Kunchithapautham K, Coughlin B, Lemasters JJ, Rohrer B. Differential effects of rapamycin on rods and cones during light-induced stress in albino mice. Invest Ophthalmol Vis Sci. .52(6):2967-75, 2011. PMCID: PMC3109010
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| | 27. | Kim I, Lemasters JJ. Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal. .14(10):1919-28, 2011. PMCID: PMC3078512
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| | 28. | Rehman H, Sun J, Shi Y, Ramshesh VK, Liu Q, Currin RT, Lemasters JJ, Zhong Z. NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liver regeneration after massive hepatectomy. Transplantation. .91(4):406-12, 2011. PMCID: PMC3399729
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| | 29. | Maldonado EN, Patnaik J, Mullins MR, Lemasters JJ. Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res. .70(24):10192-201, 2010. PMCID: PMC3010233
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| | 30. | Kim I, Lemasters JJ. Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation. Am J Physiol Cell Physiol. .300(2):C308-17, 2010. PMCID: PMC3043636
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| | 31. | Pediaditakis P, Kim JS, He L, Zhang X, Graves LM, Lemasters JJ. Inhibition of the mitochondrial permeability transition by protein kinase A in rat liver mitochondria and hepatocytes. Biochem J. .431(3):411-21, 2010. PMCID: PMC3501339
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| | 32. | Ramachandran A, Lebofsky M, Baines CP, Lemasters JJ, Jaeschke H. Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. Free Radic Res. .45(2):156-64, 2010.
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| | 33. | Lehnert M, Lind H, Zhong Z, Schoonhoven R, Marzi I, Lemasters JJ. Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats. BMC Complement Altern Med. .10:46, 2010. PMCID: PMC2936410
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| | 34. | Yan HM, Ramachandran A, Bajt ML, Lemasters JJ, Jaeschke H. The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes. Toxicol Sci. .117(2):515-23, 2010. PMCID: PMC2940407
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| | 35. | Kon K, Kim JS, Uchiyama A, Jaeschke H, Lemasters JJ. Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol Sci. .117(1):101-8, 2010. PMCID: PMC2923283
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| | 36. | Saito C, Lemasters JJ, Jaeschke H. c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol. .246(1-2):8-17, 2010. PMCID: PMC2885557
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| | 37. | Jones DP, Lemasters JJ, Han D, Boelsterli UA, Kaplowitz N. Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv. .10(2):98-111, 2010. PMCID: PMC2895369
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| | 38. | Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA, Brenner DA, Lemasters JJ. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl. .16(2):181-90, 2010. PMCID: PMC2834418
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| | 39. | Tikunov A, Johnson CB, Pediaditakis P, Markevich N, Macdonald JM, Lemasters JJ, Holmuhamedov E. Closure of VDAC causes oxidative stress and accelerates the Ca(2+)-induced mitochondrial permeability transition in rat liver mitochondria. Arch Biochem Biophys. .495(2):174-81, 2010. PMCID: PMC2855314
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| | 40. | Rodriguez-Enriquez S, Kai Y, Maldonado E, Currin RT, Lemasters JJ. Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy. .5(8):1099-106, 2009.
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| | 41. | Quiogue G, Saggu S, Hung HI, Kenney ME, Oleinick NL, Lemasters JJ, Nieminen AL. Signaling From Lysosomes Enhances Mitochondria-Mediated Photodynamic Therapy In Cancer Cells. Proc Soc Photo Opt Instrum Eng. .7380(73800C):1-8, 2009. PMCID: PMC2836728
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| | 42. | Lemasters JJ, Theruvath TP, Zhong Z, Nieminen AL. Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta. .1787(11):1395-401, 2009. PMCID: PMC2730424
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| | 43. | Holmuhamedov E, Lemasters JJ. Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes. Arch Biochem Biophys. .481(2):226-33, 2008. PMCID: PMC2656607
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| | 44. | Ramshesh VK, Lemasters JJ. Pinhole shifting lifetime imaging microscopy. J Biomed Opt. .13(6):064001, 2008. PMCID: PMC2743888
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| | 45. | Uchiyama A, Kim JS, Kon K, Jaeschke H, Ikejima K, Watanabe S, Lemasters JJ. Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology. .48(5):1644-54, 2008. PMCID: PMC2579320
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| | 46. | Rehman H, Ramshesh VK, Theruvath TP, Kim I, Currin RT, Giri S, Lemasters JJ, Zhong Z. NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice. J Pharmacol Exp Ther. .327(3):699-706, 2008. PMCID: PMC2582973
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| | 47. | Zhong Z, Ramshesh VK, Rehman H, Currin RT, Sridharan V, Theruvath TP, Kim I, Wright GL, Lemasters JJ. Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. .295(4):G823-32, 2008. PMCID: PMC2575910
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| | 48. | Theruvath TP, Czerny C, Ramshesh VK, Zhong Z, Chavin KD, Lemasters JJ. C-Jun N-terminal kinase 2 promotes graft injury via the mitochondrial permeability transition after mouse liver transplantation. Am J Transplant. .8(9):1819-28, 2008. PMCID: PMC2656603
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| | 49. | Theruvath TP, Snoddy MC, Zhong Z, Lemasters JJ. Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2. Transplantation. .85(10):1500-4, 2008. PMCID: PMC2656605
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| | 50. | Rehman H, Connor HD, Ramshesh VK, Theruvath TP, Mason RP, Wright GL, Lemasters JJ, Zhong Z. Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation. .85(9):1322-31, 2008.
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| | 51. | Theruvath TP, Zhong Z, Pediaditakis P, Ramshesh VK, Currin RT, Tikunov A, Holmuhamedov E, Lemasters JJ. Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology. .47(1):236-46, 2008. PMCID: PMC2656601
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| | 52. | Bajt ML, Farhood A, Lemasters JJ, Jaeschke H. Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity. J Pharmacol Exp Ther. .324(1):8-14, 2007.
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| | 53. | Black D, Lyman S, Qian T, Lemasters JJ, Rippe RA, Nitta T, Kim JS, Behrns KE. Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species. Biochimie. .89(12):1464-73, 2007. PMCID: PMC2151473
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| | 54. | Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol. .22 Suppl 1:S31-7, 2007.
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| | 55. | Zhong Z, Theruvath TP, Currin RT, Waldmeier PC, Lemasters JJ. NIM811, a mitochondrial permeability transition inhibitor, prevents mitochondrial depolarization in small-for-size rat liver grafts. Am J Transplant. .7(5):1103-11, 2007.
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| | 56. | Kim I, Rodriguez-Enriquez S, Lemasters JJ. Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys. .462(2):245-53, 2007. PMCID: PMC2756107
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| | 57. | Conzelmann LO, Hines IN, Kremer M, Perry AW, Lemasters JJ, Wheeler MD. Extrahepatic cells contribute to the progenitor/stem cell response following reduced-size liver transplantation in mice. Exp Biol Med (Maywood). .232(4):571-80, 2007.
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| | 58. | Le SB, Hailer MK, Buhrow S, Wang Q, Flatten K, Pediaditakis P, Bible KC, Lewis LD, Sausville EA, Pang YP, Ames MM, Lemasters JJ, Holmuhamedov EL, Kaufmann SH. Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity. J Biol Chem. .282(12):8860-72, 2007.
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| | 59. | Lemasters JJ, Ramshesh VK. Imaging of mitochondrial polarization and depolarization with cationic fluorophores. Methods Cell Biol. .80:283-95, 2007.
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| | 60. | Hammond LE, Albright CD, He L, Rusyn I, Watkins SM, Doughman SD, Lemasters JJ, Coleman RA. Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Exp Mol Pathol. .82(2):210-9, 2006. PMCID: PMC1865130
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| | 61. | Theruvath TP, Zhong Z, Currin RT, Ramshesh VK, Lemasters JJ. Endothelial nitric oxide synthase protects transplanted mouse livers against storage/reperfusion injury: Role of vasodilatory and innate immunity pathways. Transplant Proc. .38(10):3351-7, 2006. PMCID: PMC1783609
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| | 62. | Conzelmann LO, Lehnert M, Kremer M, Zhong Z, Wheeler MD, Lemasters JJ. Graft tumor necrosis factor receptor-1 protects after mouse liver transplantation whereas host tumor necrosis factor receptor-1 promotes injury. Transplantation. .82(9):1214-20, 2006.
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| | 63. | Kim JS, Lemasters JJ. Opioid receptor-independent protection of ischemic rat hepatocytes by morphine. Biochem Biophys Res Commun. .351(4):958-64, 2006. PMCID: PMC1783610
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| | 64. | Zhong Z, Connor HD, Li X, Mason RP, Forman DT, Lemasters JJ, Thurman RG. Reduction of ciclosporin and tacrolimus nephrotoxicity by plant polyphenols. J Pharm Pharmacol. .58(11):1533-43, 2006.
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| | 65. | Raval J, Lyman S, Nitta T, Mohuczy D, Lemasters JJ, Kim JS, Behrns KE. Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes. Free Radic Biol Med. .41(11):1645-54, 2006. PMCID: PMC1773006
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| | 66. | Bajt ML, Cover C, Lemasters JJ, Jaeschke H. Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci. .94(1):217-25, 2006.
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| | 67. | Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H, Brenner DA, Lemasters JJ. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation. .82(2):241-50, 2006.
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| | 68. | Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z, Brenner DA, Marzi I, Lemasters JJ. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol. .291(3):G456-63, 2006.
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| | 69. | Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl. .12(4):550-9, 2006.
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| | 70. | Chimalakonda AP, Montgomery DL, Weidanz JA, Shaik IH, Nguyen JH, Lemasters JJ, Kobayashi E, Mehvar R. Attenuation of acute rejection in a rat liver transplantation model by a liver-targeted dextran prodrug of methylprednisolone. Transplantation. .81(5):678-85, 2006. PMCID: PMC1483062
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| | 71. | Malhi H, Gores GJ, Lemasters JJ. Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology. .43(2 Suppl 1):S31-44, 2006.
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| | 72. | Rodriguez-Enriquez S, Kim I, Currin RT, Lemasters JJ. Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy. .2(1):39-46, 2006.
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| | 73. | Kim JS, Jin Y, Lemasters JJ. Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion. Am J Physiol Heart Circ Physiol. .290(5):H2024-34, 2006.
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| | 74. | Lemasters JJ, Holmuhamedov E. Voltage-dependent anion channel (VDAC) as mitochondrial governator--thinking outside the box. Biochim Biophys Acta. .1762(2):181-90, 2005.
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| | 75. | Vairetti M, Richelmi P, Bertè F, Currin RT, Lemasters JJ, Imberti R. Role of pH in protection by low sodium against hypoxic injury in isolated perfused rat livers. J Hepatol. .44(5):894-901, 2005.
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| | 76. | He L, Lemasters JJ. Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition. Biochem Biophys Res Commun. .334(3):829-37, 2005.
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| | 77. | Bustamante E, Pediaditakis P, He L, Lemasters JJ. Isolated mouse liver mitochondria are devoid of glucokinase. Biochem Biophys Res Commun. .334(3):907-10, 2005.
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| | 78. | Cover C, Mansouri A, Knight TR, Bajt ML, Lemasters JJ, Pessayre D, Jaeschke H. Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther. .315(2):879-87, 2005.
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| | 79. | Zhong Z, Connor HD, Froh M, Bunzendahl H, Lind H, Lehnert M, Mason RP, Thurman RG, Lemasters JJ. Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols. Gastroenterology. .129(2):652-64, 2005.
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| | 80. | Lemasters JJ. Dying a thousand deaths: redundant pathways from different organelles to apoptosis and necrosis. Gastroenterology. .129(1):351-60, 2005.
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| | 81. | Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res. .8(1):3-5, 2005.
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| | 82. | Kim JS, Ohshima S, Pediaditakis P, Lemasters JJ. Nitric oxide: a signaling molecule against mitochondrial permeability transition- and pH-dependent cell death after reperfusion. Free Radic Biol Med. .37(12):1943-50, 2004.
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| | 83. | Rodriguez-Enriquez S, He L, Lemasters JJ. Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol. .36(12):2463-72, 2004.
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| | 84. | Kon K, Kim JS, Jaeschke H, Lemasters JJ. Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology. .40(5):1170-9, 2004.
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| | 85. | Zhong Z, Lemasters JJ. Role of free radicals in failure of fatty liver grafts caused by ethanol. Alcohol. .34(1):49-58, 2004.
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| | 86. | Kim JS, Ohshima S, Pediaditakis P, Lemasters JJ. Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. Hepatology. .39(6):1533-43, 2004.
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| | 87. | Moshage H. The cirrhotic hepatocyte: navigating between Scylla and Charybdis. J Hepatol. .40(6):1027-9, 2004.
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| | 88. | Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. .40(6):942-51, 2004.
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| | 89. | Zhong Z, Connor HD, Froh M, Lind H, Bunzendahl H, Mason RP, Thurman RG, Lemasters JJ. Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats. Free Radic Biol Med. .36(10):1248-58, 2004.
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| | 90. | Lemasters JJ. Whither our libraries? Gastroenterology. .126(5):1234, 2004.
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| | 91. | Bajt ML, Knight TR, Lemasters JJ, Jaeschke H. Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci. .80(2):343-9, 2004.
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| | 92. | Tian Y, Graf R, Clavien PA. Reconstruction of the hepatic artery in liver transplantation in mice: mandatory or useless? Transplantation. .77(8):1310; author reply: 1310-1, 1311-2, 2004.
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| | 93. | Rauen U, Petrat F, Sustmann R, de Groot H. Iron-induced mitochondrial permeability transition in cultured hepatocytes. J Hepatol. .40(4):607-15, 2004.
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| | 94. | Lemasters JJ. Rusty notions of cell injury. J Hepatol. .40(4):696-8, 2004.
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| | 95. | Takei Y, Maruyama A, Ferdous A, Nishimura Y, Kawano S, Ikejima K, Okumura S, Asayama S, Nogawa M, Hashimoto M, Makino Y, Kinoshita M, Watanabe S, Akaike T, Lemasters JJ, Sato N. Targeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan-glycocalyx. FASEB J. .18(6):699-701, 2004.
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| | 96. | Elmore SP, Nishimura Y, Qian T, Herman B, Lemasters JJ. Discrimination of depolarized from polarized mitochondria by confocal fluorescence resonance energy transfer. Arch Biochem Biophys. .422(2):145-52, 2004.
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| | 97. | Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J. .18(6):720-2, 2004.
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| | 98. | Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology. .126(2):529-40, 2004.
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| | 99. | Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology. .125(4):1246-57, 2003.
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| | 100. | Zhao Y, Ding WX, Qian T, Watkins S, Lemasters JJ, Yin XM. Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement. Gastroenterology. .125(3):854-67, 2003.
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| | 101. | Kim JS, He L, Qian T, Lemasters JJ. Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocytes. Curr Mol Med. .3(6):527-35, 2003.
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| | 102. | Conzelmann LO, Zhong Z, Bunzendahl H, Wheeler MD, Lemasters JJ. Reduced-size liver transplantation in the mouse. Transplantation. .76(3):496-501, 2003.
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| | 103. | Waldmeier PC, Zimmermann K, Qian T, Tintelnot-Blomley M, Lemasters JJ. Cyclophilin D as a drug target. Curr Med Chem. .10(16):1485-506, 2003.
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| | 104. | Kim JS, He L, Lemasters JJ. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun. .304(3):463-70, 2003.
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| | 105. | Oh KW, Qian T, Brenner DA, Lemasters JJ. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci. .73(1):44-52, 2003.
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