Research Interest:
1) To develop strategies that would generate a robust and long-lived anti-tumor CTL response 2)To engineer T cell expressing tumor epitope specific T Cell Receptor (TCR) 3)To determine the strength of TCR receptor signaling in deciding the fate of CTL towards life or death
Selected Publications:
| 1. | Mosenson JA, Zloza A, Nieland JD, Garrett-Mayer E, Eby JM, Huelsmann EJ, Kumar P, Denman CJ, Lacek AT, Kohlhapp FJ, Alamiri A, Hughes T, Bines SD, Kaufman HL, Overbeck A, Mehrotra S, Hernandez C, Nishimura MI, Guevara-Patino JA, Le Poole IC. Mutant HSP70 reverses autoimmune depigmentation in vitiligo. Sci Transl Med. .5(174):174ra28, 2013.
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| | 2. | Kesarwani P, Murali AK, Al-Khami AA, Mehrotra S. Redox Regulation of T-Cell Function: From Molecular Mechanisms to Significance in Human Health and Disease. Antioxid Redox Signal. ., 2012.
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| | 3. | Mehrotra S, Al-Khami AA, Klarquist J, Husain S, Naga O, Eby JM, Murali AK, Lyons GE, Li M, Spivey ND, Norell H, Martins da Palma T, Onicescu G, Diaz-Montero CM, Garrett-Mayer E, Cole DJ, Le Poole IC, Nishimura MI. A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice. J Immunol. .189(4):1627-38, 2012.
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| | 4. | Ponnusamy S, Selvam SP, Mehrotra S, Kawamori T, Snider AJ, Obeid LM, Shao Y, Sabbadini R, Ogretmen B. Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med. .4(8):761-75, 2012. PMCID: PMC3494075
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| | 5. | Zheng YY, Viswanathan B, Kesarwani P, Mehrotra S. Dietary agents in cancer prevention: an immunological perspective. Photochem Photobiol. .88(5):1083-98, 2012.
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| | 6. | Kaur N, Naga OS, Norell H, Al-Khami AA, Scheffel MJ, Chakraborty NG, Voelkel-Johnson C, Mukherji B, Mehrotra S. T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules. Cytokine. .55(2):307-17, 2011.
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| | 7. | Al-Khami AA, Mehrotra S, Nishimura MI. Adoptive immunotherapy of cancer: Gene transfer of T cell specificity. Self Nonself. .2(2):80-84, 2011. PMCID: PMC3268993
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| | 8. | Klarquist J, Denman CJ, Hernandez C, Wainwright DA, Wainwright DJ, Strickland FM, Overbeck A, Mehrotra S, Nishimura MI, Le Poole IC. Reduced skin homing by functional Treg in vitiligo. Pigment Cell Melanoma Res. .23(2):276-86, 2010.
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| | 9. | Ray S, Chhabra A, Mehrotra S, Chakraborty NG, Ribas A, Economou J, Mukherji B. Obstacles to and opportunities for more effective peptide-based therapeutic immunization in human melanoma. Clin Dermatol. .27(6):603-13, 2009.
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| | 10. | Norell H, Martins da Palma T, Lesher A, Kaur N, Mehrotra M, Naga OS, Spivey N, Olafimihan S, Chakraborty NG, Voelkel-Johnson C, Nishimura MI, Mukherji B, Mehrotra S. Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-1(27-35)-reactive T cells from activation-induced cell death. Cancer Res. .69(15):6282-9, 2009. PMCID: PMC2719828
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| | 11. | Mehrotra S, Mougiakakos D, Johansson CC, Voelkel-Johnson C, Kiessling R. Oxidative stress and lymphocyte persistence: implications in immunotherapy. Adv Cancer Res. .102:197-227, 2009.
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| | 12. | Chhabra A, Yang L, Wang P, Comin-Anduix B, Das R, Chakraborty NG, Ray S, Mehrotra S, Yang H, Hardee CL, Hollis R, Dorsky DI, Koya R, Kohn DB, Ribas A, Economou JS, Baltimore D, Mukherji B. CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model. J Immunol. .181(2):1063-70, 2008. PMCID: PMC2715965
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| | 13. | Chhabra A, Mehrotra S, Chakraborty NG, Dorsky DI, Mukherji B. Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor. Eur J Immunol. .36(12):3167-74, 2006.
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| | 14. | Mehrotra S, Chhabra A, Hegde U, Chakraborty NG, Mukherji B. Inhibition of c-Jun N-terminal kinase rescues influenza epitope-specific human cytolytic T lymphocytes from activation-induced cell death. J Leukoc Biol. .81(2):539-47, 2006.
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| | 15. | Chattopadhyay S, Mehrotra S, Chhabra A, Hegde U, Mukherji B, Chakraborty NG. Effect of CD4+CD25+ and CD4+CD25- T regulatory cells on the generation of cytolytic T cell response to a self but human tumor-associated epitope in vitro. J Immunol. .176(2):984-90, 2006.
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| | 16. | Mehrotra S, Zaidi N, Chakraborty NG, Mukherji B. Macrophages as stimulators of MART-1 27-35 epitope-specific human cytolytic T lymphocytes in vitro. Pathobiology. .73(5):238-43, 2006.
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| | 17. | Yadav VS, Mishra KP, Singh DP, Mehrotra S, Singh VK. Immunomodulatory effects of curcumin. Immunopharmacol Immunotoxicol. .27(3):485-97, 2005.
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| | 18. | Mehrotra S, Chhabra A, Chakraborty A, Chattopadhyay S, Slowik M, Stevens R, Zengou R, Mathias C, Butterfield LH, Dorsky DI, Economou JS, Mukherji B, Chakraborty NG. Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells. Immunology. .113(4):472-81, 2004. PMCID: PMC1782594
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| | 19. | Mehrotra S, Chhabra A, Chattopadhyay S, Dorsky DI, Chakraborty NG, Mukherji B. Rescuing melanoma epitope-specific cytolytic T lymphocytes from activation-induced cell death, by SP600125, an inhibitor of JNK: implications in cancer immunotherapy. J Immunol. .173(10):6017-24, 2004.
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| | 20. | Chhabra A, Mehrotra S, Chakraborty NG, Mukherji B, Dorsky DI. Cross-presentation of a human tumor antigen delivered to dendritic cells by HSV VP22-mediated protein translocation. Eur J Immunol. .34(10):2824-33, 2004.
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| | 21. | Chakraborty NG, Chattopadhyay S, Mehrotra S, Chhabra A, Mukherji B. Regulatory T-cell response and tumor vaccine-induced cytotoxic T lymphocytes in human melanoma. Hum Immunol. .65(8):794-802, 2004.
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| | 22. | Mehrotra S, Stevens R, Zengou R, Chakraborty NG, Butterfield LH, Economou JS, Dorsky DI, Mukherji B. Regulation of melanoma epitope-specific cytolytic T lymphocyte response by immature and activated dendritic cells, in vitro. Cancer Res. .63(17):5607-14, 2003.
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| | 23. | Mehrotra S, Mishra KP, Yadav VS, Bhattacharya M, Pandey D, Haq W, Singh VK. Immunomodulation by peptide analogs of retroviral envelope protein. Peptides. .24(7):979-85, 2003.
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| | 24. | Chakraborty NG, Stevens RL, Mehrotra S, Laska E, Taxel P, Sporn JR, Schauer P, Albertsen PC. Recognition of PSA-derived peptide antigens by T cells from prostate cancer patients without any prior stimulation. Cancer Immunol Immunother. .52(8):497-505, 2003.
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| | 25. | Mehrotra S, Mishra KP, Maurya R, Srimal RC, Yadav VS, Pandey R, Singh VK. Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizome. Int Immunopharmacol. .3(1):53-61, 2003.
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| | 26. | Mehrotra S, Singh VK, Agarwal SS, Maurya R, Srimal RC. Antilymphoproliferative activity of ethanolic extract of Boerhaavia diffusa roots. Exp Mol Pathol. .72(3):236-42, 2002.
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| | 27. | Mehrotra S, Mishra KP, Maurya R, Srimal RC, Singh VK. Immunomodulation by ethanolic extract of Boerhaavia diffusa roots. Int Immunopharmacol. .2(7):987-96, 2002.
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| | 28. | Mehrotra S, Prajapati RK, Haq W, Singh VK. Immunomodulation by biphalin, dimeric synthetic opioid peptide, and its analog. Immunopharmacol Immunotoxicol. .24(1):83-96, 2002.
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| | 29. | Singh VK, Mehrotra S, Narayan P, Pandey CM, Agarwal SS. Modulation of autoimmune diseases by nitric oxide. Immunol Res. .22(1):1-19, 2000.
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