Research Interest:
Preclinical development and pharmacokinetic/dynamic analysis of anti-cancer agents for the treatment of solid tumors
Selected Publications:
| 1. | Maldonado EN, Sheldon KL, Dehart DN, Patnaik J, Manevich Y, Townsend DM, Berzukov SM, Rostovtseva TK, Lemasters JJ. Voltage dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J Biol Chem. ., 2013.
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| | 2. | Manevich Y, Hutchens S, Tew KD, Townsend DM. Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation. Free Radic Biol Med. ., 2012.
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| | 3. | Bowers RR, Manevich Y, Townsend DM, Tew KD. Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility. Biochemistry. .51(39):7740-54, 2012. PMCID: PMC3472422
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| | 4. | Mack JT, Brown CB, Garrett TE, Uys JD, Townsend DM, Tew KD. Ablation of the ATP-binding cassette transporter, Abca2 modifies response to estrogen-based therapies. Biomed Pharmacother. .66(6):403-8, 2012.
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| | 5. | Tew KD, Townsend DM. Glutathione-s-transferases as determinants of cell survival and death. Antioxid Redox Signal. .17(12):1728-37, 2012. PMCID: PMC3474190
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| | 6. | Xiong Y, Manevich Y, Tew KD, Townsend DM. S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor a Stability and Function. Int J Cell Biol. .2012:273549, 2012. PMCID: PMC3359683
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| | 7. | Grek CL, Townsend DM, Uys JD, Manevich Y, Coker WJ, Pazoles CJ, Tew KD. S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs. Cancer Res. .72(9):2383-93, 2012.
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| | 8. | Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-ß production by altering Nicastrin maturation and intracellular localization. J Biol Chem. .287(2):1100-11, 2011. PMCID: PMC3256850
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| | 9. | Uys JD, Knackstedt L, Hurt P, Tew KD, Manevich Y, Hutchens S, Townsend DM, Kalivas PW. Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity. Neuropsychopharmacology. .36(12):2551-60, 2011. PMCID: PMC3194081
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| | 10. | Xiong Y, Uys JD, Tew KD, Townsend DM. S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal. .15(1):233-70, 2011. PMCID: PMC3110090
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| | 11. | Tew KD, Manevich Y, Grek C, Xiong Y, Uys J, Townsend DM. The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer. Free Radic Biol Med. .51(2):299-313, 2011. PMCID: PMC3125017
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| | 12. | Tew KD, Townsend DM. Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification. Drug Metab Rev. .43(2):179-93, 2011.
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| | 13. | Uys JD, Xiong Y, Townsend DM. Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase. Methods Enzymol. .490:321-32, 2011.
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| | 14. | Manevich Y, Townsend DM, Hutchens S, Tew KD. Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase. PLoS One. .5(11):e14151, 2010. PMCID: PMC2994766
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| | 15. | Tew KD, Townsend DM. Redox platforms in cancer drug discovery and development. Curr Opin Chem Biol. .15(1):156-61, 2010. PMCID: PMC3073687
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| | 16. | Mack JT, Helke KL, Normand G, Green C, Townsend DM, Tew KD. ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration. Cancer Lett. .300(2):154-61, 2010. PMCID: PMC2994978
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| | 17. | Grek CL, Townsend DM, Tew KD. The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies. Pharmacol Ther. .129(2):172-84, 2010. PMCID: PMC3026067
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| | 18. | Goetzl L, Manevich Y, Roedner C, Praktish A, Hebbar L, Townsend DM. Maternal and fetal oxidative stress and intrapartum term fever. Am J Obstet Gynecol. .202(4):363.e1-5, 2010.
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| | 19. | Lenna S, Townsend DM, Tan FK, Kapanadze B, Markiewicz M, Trojanowska M, Scorza R. HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. J Immunol. .184(9):4654-61, 2010.
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| | 20. | Hutchens S, Manevich Y, He L, Tew KD, Townsend DM. Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO. Invest New Drugs. .29(5):719-29, 2010. PMCID: PMC2912140
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| | 21. | Uys JD, Manevich Y, Devane LC, He L, Garret TE, Pazoles CJ, Tew KD, Townsend DM. Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic. Biomed Pharmacother. .64(7):493-8, 2010. PMCID: PMC2921589
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| | 22. | Spassieva SD, Mullen TD, Townsend DM, Obeid LM. Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. Biochem J. .424(2):273-83, 2009.
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| | 23. | Jenderny S, Lin H, Garrett T, Tew KD, Townsend DM. Protective effects of a glutathione disulfide mimetic (NOV-002) against cisplatin induced kidney toxicity. Biomed Pharmacother. .64(1):73-6, 2009. PMCID: PMC3388846
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| | 24. | Townsend DM, Manevich Y, He L, Xiong Y, Bowers RR, Hutchens S, Tew KD. Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response. Cancer Res. .69(19):7626-34, 2009. PMCID: PMC2756322
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| | 25. | Hanigan MH, Townsend DM, Cooper AJ. Metabolism of cisplatin to a nephrotoxin. Toxicology. .257(3):174-5; author reply 176-7, 2008. PMCID: PMC2708784
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| | 26. | Townsend DM, Manevich Y, He L, Hutchens S, Pazoles CJ, Tew KD. Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress. J Biol Chem. .284(1):436-45, 2008. PMCID: PMC2610519
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| | 27. | Townsend DM, Tew KD. Pharmacology of a mimetic of glutathione disulfide, NOV-002. Biomed Pharmacother. .63(2):75-8, 2008. PMCID: PMC2657662
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| | 28. | Townsend DM, Tew KD, He L, King JB, Hanigan MH. Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity. Biomed Pharmacother. .63(2):79-85, 2008. PMCID: PMC2667699
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| | 29. | Townsend DM, Pazoles CJ, Tew KD. NOV-002, a mimetic of glutathione disulfide. Expert Opin Investig Drugs. .17(7):1075-83, 2008.
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| | 30. | Lei K, Townsend DM, Tew KD. Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response. Oncogene. .27(36):4877-87, 2008. PMCID: PMC3399212
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| | 31. | Townsend DM, He L, Hutchens S, Garrett TE, Pazoles CJ, Tew KD. NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance. Cancer Res. .68(8):2870-7, 2008. PMCID: PMC3397193
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| | 32. | Townsend DM. S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response. Mol Interv. .7(6):313-24, 2007.
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| | 33. | Mack JT, Townsend DM, Beljanski V, Tew KD. The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds. Curr Drug Metab. .8(1):47-57, 2007.
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| | 34. | Mack JT, Beljanski V, Soulika AM, Townsend DM, Brown CB, Davis W, Tew KD. "Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mol Cell Biol. .27(1):44-53, 2006. PMCID: PMC1800669
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| | 35. | Mack JT, Beljanski V, Tew KD, Townsend DM. The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking. Biomed Pharmacother. .60(9):587-92, 2006.
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| | 36. | Findlay VJ, Townsend DM, Morris TE, Fraser JP, He L, Tew KD. A novel role for human sulfiredoxin in the reversal of glutathionylation. Cancer Res. .66(13):6800-6, 2006.
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| | 37. | McIlwain CC, Townsend DM, Tew KD. Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene. .25(11):1639-48, 2006.
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| | 38. | Saavedra JE, Srinivasan A, Buzard GS, Davies KM, Waterhouse DJ, Inami K, Wilde TC, Citro ML, Cuellar M, Deschamps JR, Parrish D, Shami PJ, Findlay VJ, Townsend DM, Tew KD, Singh S, Jia L, Ji X, Keefer LK. PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity. J Med Chem. .49(3):1157-64, 2006.
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| | 39. | Townsend DM, Findlay VJ, Fazilev F, Ogle M, Fraser J, Saavedra JE, Ji X, Keefer LK, Tew KD. A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins. Mol Pharmacol. .69(2):501-8, 2005.
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| | 40. | Tucker JM, Lipatova Z, Beljanski V, Townsend DM, Tew KD. Evaluation of lipophilins as determinants of tumor cell response to estramustine. J Pharmacol Exp Ther. .315(3):1158-62, 2005.
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| | 41. | Tucker JM, Townsend DM. Alpha-tocopherol: roles in prevention and therapy of human disease. Biomed Pharmacother. .59(7):380-7, 2005.
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| | 42. | Findlay VJ, Tapiero H, Townsend DM. Sulfiredoxin: a potential therapeutic agent? Biomed Pharmacother. .59(7):374-9, 2005.
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| | 43. | Beljanski V, Soulika A, Tucker JM, Townsend DM, Davis W, Tew KD. Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2). In Vivo. .19(4):657-60, 2005.
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| | 44. | Townsend DM, Findlay VL, Tew KD. Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets. Methods Enzymol. .401:287-307, 2005.
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| | 45. | Tew KD, Boyd JT, Chen ZJ, Davis W, Fazilev F, Findlay V, Gaté L, Ile K, Soulika A, Townsend DM. Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress. J Nutr. .134(11):3205S-3206S, 2004.
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| | 46. | Findlay VJ, Townsend DM, Saavedra JE, Buzard GS, Citro ML, Keefer LK, Ji X, Tew KD. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. Mol Pharmacol. .65(5):1070-9, 2004.
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| | 47. | Tapiero H, Townsend DM, Tew KD. Organosulfur compounds from alliaceae in the prevention of human pathologies. Biomed Pharmacother. .58(3):183-93, 2004.
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| | 48. | Tapiero H, Townsend DM, Tew KD. The role of carotenoids in the prevention of human pathologies. Biomed Pharmacother. .58(2):100-10, 2004.
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| | 49. | Townsend DM, Tew KD, Tapiero H. Sulfur containing amino acids and human disease. Biomed Pharmacother. .58(1):47-55, 2004.
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| | 50. | Tapiero H, Townsend DM, Tew KD. Trace elements in human physiology and pathology. Copper. Biomed Pharmacother. .57(9):386-98, 2003.
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| | 51. | Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene. .22(47):7369-75, 2003.
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| | 52. | Tapiero H, Townsend DM, Tew KD. Phytosterols in the prevention of human pathologies. Biomed Pharmacother. .57(8):321-5, 2003.
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| | 53. | Townsend DM, Marto JA, Deng M, Macdonald TJ, Hanigan MH. High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin. Drug Metab Dispos. .31(6):705-13, 2003.
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| | 54. | Tapiero H, Townsend DM, Tew KD. The antioxidant role of selenium and seleno-compounds. Biomed Pharmacother. .57(3-4):134-44, 2003.
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| | 55. | Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother. .57(3-4):145-55, 2003.
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| | 56. | Townsend DM, Deng M, Zhang L, Lapus MG, Hanigan MH. Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells. J Am Soc Nephrol. .14(1):1-10, 2003.
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| | 57. | Townsend DM, Shen H, Staros AL, Gaté L, Tew KD. Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells. Mol Cancer Ther. .1(12):1089-95, 2002.
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| | 58. | Townsend DM, Hanigan MH. Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice. J Pharmacol Exp Ther. .300(1):142-8, 2002.
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| | 59. | Hanigan MH, Lykissa ED, Townsend DM, Ou CN, Barrios R, Lieberman MW. Gamma-glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatin. Am J Pathol. .159(5):1889-94, 2001. PMCID: PMC1867073
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| | 60. | Hanigan MH, Gallagher BC, Townsend DM, Gabarra V. Gamma-glutamyl transpeptidase accelerates tumor growth and increases the resistance of tumors to cisplatin in vivo. Carcinogenesis. .20(4):553-9, 1999.
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